MFAP2 Gene

Name	microfibrillar-associated protein 2
Description	Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMFAP2, also known as microfibril‐associated glycoprotein‐2, is an extracellular matrix protein that plays a key role in modulating microfibril function through its interaction with fibrillin and by influencing important signaling pathways, such as Notch. Its activity is further regulated by proteolytic processing by proprotein convertases, which generate distinct extracellular fragments with potentially diverse biological actions. Moreover, altered MFAP2 expression has been linked to reproductive outcomes, as decreased MFAP2 levels have been observed in women experiencing repeated implantation failure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in extracellular matrix homeostasis, MFAP2 is emerging as a significant player in tumorigenesis. Multiple studies have demonstrated that MFAP2 is upregulated in several cancer types – including gastric cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, ovarian cancer, and oral squamous cell carcinoma – with its elevated expression correlating with poor clinical prognosis. Mechanistic insights indicate that MFAP2 can promote oncogenic processes by enhancing cell proliferation, migration, invasion, glycolysis, and autophagy. In part, these effects are mediated by the activation of the FOXM1/β‐catenin and Wnt/β‐catenin signaling pathways, underscoring its potential as a diagnostic and prognostic biomarker as well as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alison Miyamoto, Rhiana Lau, Patrick W Hein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600298200"}], "href": "https://doi.org/10.1074/jbc.M600298200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16492672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16492672"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Esengul Turkyilmaz, Haldun Guner, Mehmet Erdem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.07.031"}], "href": "https://doi.org/10.1016/j.gene.2012.07.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22885067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22885067"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lauren J Donovan, Seung E Cha, Andrew R Yale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a functional proprotein convertase cleavage site in microfibril-associated glycoprotein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2012.11.009"}], "href": "https://doi.org/10.1016/j.matbio.2012.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23201136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23201136"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Clarissa S Craft, Thomas J Broekelmann, Robert P Mecham "}, {"type": "b", "children": [{"type": "t", "text": "Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2018.03.006"}], "href": "https://doi.org/10.1016/j.matbio.2018.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29524629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29524629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tao Sun, Danhua Wang, Ying Ping, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated profiling identifies SLC5A6 and MFAP2 as novel diagnostic and prognostic biomarkers in gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4944"}], "href": "https://doi.org/10.3892/ijo.2019.4944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894266"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiang Zhu, Ye Cheng, Fan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP2 Promotes the Proliferation of Cancer Cells and Is Associated With a Poor Prognosis in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820977524"}], "href": "https://doi.org/10.1177/1533033820977524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33280519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33280519"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zexing Shan, Wentao Wang, Yilin Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as Prognosis Markers of Overall Survival in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.929558"}], "href": "https://doi.org/10.12659/MSM.929558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33758160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33758160"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ling-Qin Zhao, Wei Sun, Ping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP2 aggravates tumor progression through activating FOXM1/β-catenin-mediated glycolysis in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12546"}], "href": "https://doi.org/10.1002/kjm2.12546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35546486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35546486"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hao Zhang, Si Shen, Chong Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2023079"}], "href": "https://doi.org/10.3724/abbs.2023079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37592847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37592847"}]}]}]}
Synonyms	MAGP1, MAGP, MAGP-1
Proteins	MFAP2_HUMAN
NCBI Gene ID	4237
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MFAP2 has 8,130 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for MFAP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MFAP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MFAP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MFAP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MFAP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MFAP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MFAP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MFAP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MFAP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MFAP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MFAP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MFAP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MFAP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MFAP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MFAP2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MFAP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MFAP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MFAP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MFAP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MFAP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MFAP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MFAP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MFAP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MFAP2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MFAP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MFAP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MFAP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MFAP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MFAP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MFAP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MFAP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MFAP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MFAP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MFAP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MFAP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MFAP2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MFAP2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MFAP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MFAP2 from the GeneSigDB Published Gene Signatures dataset.