MFAP5 Gene

Name	microfibrillar associated protein 5
Description	This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicrofibrillar‐associated protein 5 (MFAP5) is an extracellular matrix glycoprotein integral to microfibril assembly that has emerged as a key modulator in the tumor microenvironment. Predominantly secreted by cancer‐associated fibroblasts, high MFAP5 expression is associated with aggressive tumor behavior and poor patient prognosis in a variety of carcinomas—including ovarian, breast, cervical, bladder, and oral tongue cancers. MFAP5 promotes tumor cell motility, invasion, and angiogenesis by activating several intracellular signaling cascades such as FAK/CREB/TNNC1, MAPK/AKT, ERK, and NOTCH pathways, thereby enhancing metastatic potential and disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn preclinical models, targeting MFAP5 has demonstrated therapeutic promise. Specifically, the use of MFAP5‐neutralizing monoclonal antibodies in ovarian and pancreatic cancer settings led to significant reductions in tumor growth and metastasis, highlighting MFAP5 as a potential treatment target to modulate the malignant stroma and improve clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic roles, MFAP5 is crucial for extracellular matrix remodeling in multiple tissue types. Its expression is dynamically modulated in adipose tissue during weight loss"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and epigenetic alterations such as hypomethylation in the regulatory regions of the MFAP5 gene have been observed in varicose veins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, MFAP5 has been evaluated as a diagnostic marker in colonic lesions, where its differential stromal expression may help distinguish invasive adenocarcinoma from pseudoinvasion in colon polyps."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, genetic studies have identified MFAP5 mutations that compromise extracellular matrix integrity, contributing to vascular pathologies such as thoracic aortic aneurysm and dissection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, MFAP5 not only serves a structural role in microfibril assembly but also actively orchestrates key signaling events that drive tumor progression, angiogenesis, and tissue remodeling. Its multifaceted functions render it both a valuable prognostic biomarker and an attractive therapeutic target across diverse pathological contexts.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cecilia S Leung, Tsz-Lun Yeung, Kay-Pong Yip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6092"}], "href": "https://doi.org/10.1038/ncomms6092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25277212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25277212"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiqiang Wu, Ting Wang, Meng Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.03.007"}], "href": "https://doi.org/10.1016/j.bbrc.2018.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29526753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29526753"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Simona Principe, Salvador Mejia-Guerrero, Vladimir Ignatchenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.7b00925"}], "href": "https://doi.org/10.1021/acs.jproteome.7b00925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29681158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29681158"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingmei Li, Yanqin Zhang, Qiuli Jiang "}, {"type": "b", "children": [{"type": "t", "text": "MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.10.146"}], "href": "https://doi.org/10.1016/j.bbrc.2018.10.146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30454902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30454902"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xi Yang, Kailiu Wu, Siyi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12446"}], "href": "https://doi.org/10.18632/oncotarget.12446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27713166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27713166"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zheng Zhou, Di Cui, Meng-Hao Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201902659R"}], "href": "https://doi.org/10.1096/fj.201902659R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32293074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32293074"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tsz-Lun Yeung, Cecilia S Leung, Kay-Pong Yip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-19-0187"}], "href": "https://doi.org/10.1158/1078-0432.CCR-19-0187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332047"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Maija Vaittinen, Marjukka Kolehmainen, Mikael Rydén, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP5 is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/oby.21103"}], "href": "https://doi.org/10.1002/oby.21103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26054006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26054006"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mariya A Smetanina, Valeria A Korolenya, Fedor A Sipin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20231938"}], "href": "https://doi.org/10.1042/BSR20231938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38743016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38743016"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lei Zhao, Maria Westerhoff, Jason L Hornick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-019-02649-y"}], "href": "https://doi.org/10.1007/s00428-019-02649-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31422503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31422503"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wei Feifei, Guo Hui, Zhao Ruiqiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGP2, a Component of Extracellular Matrix, Is Upregulated in Colorectal Cancer and Negatively Modulated by miR-200b-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033819870777"}], "href": "https://doi.org/10.1177/1533033819870777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31426719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31426719"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mathieu Barbier, Marie-Sylvie Gross, Mélodie Aubart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2014.10.018"}], "href": "https://doi.org/10.1016/j.ajhg.2014.10.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25434006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25434006"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jeffrey A Schubert, Benjamin J Landis, Amy R Shikany, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37568"}], "href": "https://doi.org/10.1002/ajmg.a.37568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26854089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26854089"}]}]}]}
Synonyms	MFAP-5, MP25, AAT9, MAGP-2, MAGP2
Proteins	MFAP5_HUMAN
NCBI Gene ID	8076
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MFAP5 has 10,153 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for MFAP5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MFAP5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MFAP5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MFAP5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MFAP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MFAP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MFAP5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MFAP5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MFAP5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MFAP5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MFAP5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MFAP5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MFAP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MFAP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MFAP5 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MFAP5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MFAP5 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MFAP5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MFAP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MFAP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MFAP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MFAP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MFAP5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MFAP5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MFAP5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MFAP5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MFAP5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MFAP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MFAP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MFAP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MFAP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MFAP5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MFAP5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MFAP5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MFAP5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MFAP5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MFAP5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MFAP5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MFAP5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MFAP5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.