{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provided details a wide array of cellular regulatory mechanisms—including nuclear transport, centrosome integrity, autophagy, gene imprinting, and cell migration—that are orchestrated by proteins such as nucleoporins (Nup62, Nup107), chaperone‐associated factors, and autophagic receptors like p62. However, none of these studies make any mention of MFSD14A nor do they shed light on its function. Consequently, no insights into the functional role of MFSD14A can be gleaned from this literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSeveral of the abstracts emphasize the critical role of nuclear pore-associated proteins and chaperone complexes in regulating the intracellular trafficking and localization of key regulatory molecules. For example, research described in abstract 1 (PMID 19581287) focuses on the chaperone‐mediated nuclear import of the glucocorticoid receptor via interactions with the nuclear pore complex, while abstracts 2 (PMID 24107630) and 10 (PMID 32554220) explore how nucleoporins such as Nup62 affect centrosome integrity and cellular differentiation. Abstract 5 (PMID 30022050) further underscores the importance of specific nucleoporins in gene imprinting and chromatin regulation.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies in this collection shift attention to cellular stress responses and quality control pathways. Abstracts 6 (PMID 37802024) and 9 (PMID 37620146) examine the regulation of selective autophagy through the dynamics of p62 and its interaction with ubiquitinated cargo, whereas abstract 7 (PMID 34571994) investigates the role of GDF-15 in modulating autophagic processes in atherosclerosis. Additionally, abstract 4 (PMID 22683860) links nuclear pore interactions with cellular migration, and abstract 8 (PMID 36908815) addresses hippocampal impairment post-traumatic brain injury. Despite these extensive insights into cellular homeostasis and signaling, MFSD14A remains unaddressed in all these reports.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pablo C Echeverría, Gisela Mazaira, Alejandra Erlejman, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporin Nup62 maintains centrosome homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.26671"}], "href": "https://doi.org/10.4161/cc.26671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24107630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24107630"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yayoi Kinoshita, Richard G Hunter, Jason D Gray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1418896111"}], "href": "https://doi.org/10.1073/pnas.1418896111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25349423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25349423"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olivier Béaslas, Terhi Vihervaara, Jiwei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2012.05.026"}], "href": "https://doi.org/10.1016/j.yexcr.2012.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22683860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22683860"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Saqib S Sachani, Lauren S Landschoot, Liyue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05208-2"}], "href": "https://doi.org/10.1038/s41467-018-05208-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30022050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30022050"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xue Huang, Jia Yao, Lu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2023.09.004"}], "href": "https://doi.org/10.1016/j.molcel.2023.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37802024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37802024"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Aline Heduschke, Kathrin Ackermann, Beate Wilhelm, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.14913"}], "href": "https://doi.org/10.7717/peerj.14913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36908815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36908815"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Riccardo Trapannone, Julia Romanov, Sascha Martens "}, {"type": "b", "children": [{"type": "t", "text": "p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202301936"}], "href": "https://doi.org/10.26508/lsa.202301936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37620146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37620146"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Patrick J Bishop, Yayoi Kinoshita, N Natalie Lopes, et al. 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