MIB1 Gene

HGNC Family	Zinc fingers, Ankyrin repeat domain containing (ANKRD)
Name	mindbomb E3 ubiquitin protein ligase 1
Description	This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIB1 is a multidomain RING‐type E3 ubiquitin ligase that plays a central role in activating Notch signaling by ubiquitinating Notch ligands—such as Delta and Jagged—to promote their endocytosis. This process is critical for proper cardiac morphogenesis, with mutations in MIB1 leading to congenital heart defects including left ventricular noncompaction and other congenital heart diseases through diminished Notch1 activity. Structural studies have further revealed that MIB1 forms functional dimers via its ccRING3 domain and employs distinct substrate recognition modules to engage multiple epitopes on ligands, thereby ensuring efficient Notch receptor activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in developmental signaling, MIB1 influences cell fate decisions by regulating apoptotic pathways. It promotes the ubiquitination and degradation of key pro‐apoptotic regulators such as DAPK, and by interacting with inhibitory proteins like cFLIP, it modulates caspase-8 activation to initiate the extrinsic cell death cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIB1 also intersects with the Wnt/β‐catenin pathway. By physically and functionally interacting with the receptor RYK and promoting its ubiquitination, MIB1 reduces the receptor's plasma membrane residency and facilitates downstream β‐catenin signaling. This activity is further underscored in pancreatic cancer, where MIB1 gene amplification correlates with enhanced β‐catenin activation and tumor proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of centrosome homeostasis and ciliogenesis, MIB1 is essential for controlling centriole duplication. It ubiquitinates Polo-like kinase 4 (Plk4) to prevent centriole amplification—a safeguard critical for maintaining genomic integrity. Furthermore, MIB1’s spatial regulation by centriolar satellites—tethered by PCM1 and modulated by deubiquitinating enzymes like CYLD—ensures proper ciliary vesicle recruitment and cilia assembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIB1’s diverse roles extend into oncogenesis and cellular senescence. In prostate cancer models, microRNAs such as miR‑198 and miR‑195‑5p directly target MIB1 to suppress cell proliferation, migration, and invasion, demonstrating its potential oncogenic function. In epithelial cells, MIB1 regulates cell polarity by ubiquitinating proteins such as EPB41L5 and CRB1, while its activity toward the WRN protein accelerates proteasomal degradation and promotes senescence. In skeletal muscle, MIB1 maintains tissue integrity by degrading α‑actinin 3 (Actn3), with its disruption leading to atrophy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neurodegenerative settings, particularly Parkinson’s disease models, MIB1 regulates inflammasome activity. It controls the ubiquitination of TXNIP, a key modulator of NLRP3 inflammasome activation, thereby contributing to the regulation of neuroinflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLastly, in breast cancer, MIB1 has been implicated in the suppression of cancer cell migration. Alteration in MIB1 levels affects the stability of adhesion-related proteins such as CTNND1, leading to changes in E-cadherin membrane localization and influencing epithelial morphology and tumor cell dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ran Song, Bon-Kyoung Koo, Ki-Jun Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M606601200"}], "href": "https://doi.org/10.1074/jbc.M606601200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17003037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17003037"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guillermo Luxán, Jesús C Casanova, Beatriz Martínez-Poveda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3046"}], "href": "https://doi.org/10.1038/nm.3046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23314057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23314057"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Brian J McMillan, Björn Schnute, Nadja Ohlenhard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.01.019"}], "href": "https://doi.org/10.1016/j.molcel.2015.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25747658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25747658"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Binbin Li, Liwei Yu, Dong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20180732"}], "href": "https://doi.org/10.1042/CS20180732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30322850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30322850"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ruili Cao, Oren Gozlan, Alina Airich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural requirements for activity of Mind bomb1 in Notch signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2024.07.011"}], "href": "https://doi.org/10.1016/j.str.2024.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39121852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39121852"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liguo Zhang, Kenneth P Nephew, Patricia J Gallagher "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M610430200"}], "href": "https://doi.org/10.1074/jbc.M610430200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17324930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17324930"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liguo Zhang, Patricia J Gallagher "}, {"type": "b", "children": [{"type": "t", "text": "Mind bomb 1 regulation of cFLIP interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00214.2009"}], "href": "https://doi.org/10.1152/ajpcell.00214.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19710364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19710364"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jason D Berndt, Atsushi Aoyagi, Peitzu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201107021"}], "href": "https://doi.org/10.1083/jcb.201107021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21875946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21875946"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiao Fu, Neng Tang, Weiqi Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mind Bomb 1 Promotes Pancreatic Cancer Proliferation by Activating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Catenin Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nanosci Nanotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1166/jnn.2020.18755"}], "href": "https://doi.org/10.1166/jnn.2020.18755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32711591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32711591"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lukas Čajánek, Timo Glatter, Erich A Nigg "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.166496"}], "href": "https://doi.org/10.1242/jcs.166496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25795303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25795303"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lei Wang, Kwanwoo Lee, Ryan Malonis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.12950"}], "href": "https://doi.org/10.7554/eLife.12950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27146717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27146717"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tiphaine Douanne, Gwennan André-Grégoire, An Thys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.04.036"}], "href": "https://doi.org/10.1016/j.celrep.2019.04.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31067453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31067453"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jessica Ray, Christianne Hoey, Xiaoyong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑198 suppresses prostate tumorigenesis by targeting MIB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7234"}], "href": "https://doi.org/10.3892/or.2019.7234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31322262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31322262"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sascha E Dho, Nancy Silva-Gagliardi, Fabio Morgese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-48902-x"}], "href": "https://doi.org/10.1038/s41598-019-48902-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31462741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31462741"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Meiting Li, Boya Liu, Jingjie Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000268RRR"}], "href": "https://doi.org/10.1096/fj.202000268RRR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32652764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32652764"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-21621-6"}], "href": "https://doi.org/10.1038/s41467-021-21621-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33637766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33637766"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Bin Chen, Guohui Bai, Xiaoyan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑195‑5p is associated with cell proliferation, migration and invasion in prostate cancer and targets MIB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8210"}], "href": "https://doi.org/10.3892/or.2021.8210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34698358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34698358"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ziman Zhu, Peiling Huang, Ruifeng Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Long-Noncoding RNA LncZFAS1 Prevents MPP"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-Induced Neuroinflammation Through MIB1 Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-021-02619-z"}], "href": "https://doi.org/10.1007/s12035-021-02619-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34775541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34775541"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tohgo Kanoh, Jingyu Lu, Takamasa Mizoguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.05.034"}], "href": "https://doi.org/10.1016/j.bbrc.2023.05.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37209565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37209565"}]}]}]}
Synonyms	ZZZ6, DIP-1, LVNC7, ZZANK2
Proteins	MIB1_HUMAN
NCBI Gene ID	57534
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MIB1 has 7,407 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for MIB1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MIB1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MIB1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MIB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MIB1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MIB1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MIB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MIB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MIB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MIB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MIB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MIB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MIB1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MIB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MIB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MIB1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MIB1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MIB1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MIB1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MIB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MIB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MIB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MIB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MIB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MIB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MIB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MIB1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MIB1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MIB1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MIB1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MIB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MIB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MIB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MIB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MIB1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MIB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MIB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MIB1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.