MKNK2 Gene

Name	MAP kinase interacting serine/threonine kinase 2
Description	This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMKNK2 encodes the MAPK‐interacting kinase 2 (MNK2), a serine/threonine kinase that phosphorylates the cap‐binding protein eIF4E to modulate mRNA translation. Alternative splicing of MKNK2 generates two principal isoforms—Mnk2a and Mnk2b—that exhibit distinct regulatory properties, with Mnk2a often coupling with stress pathways (such as p38‐MAPK) to exert tumor suppressive effects and Mnk2b displaying more pro‐oncogenic behavior. MNK2 also interacts with components of the initiation complex (e.g., via binding to eIF4G) and can be further modulated by upstream signals, including MAP kinases and cytokine stimuli, thereby integrating inflammatory and metabolic cues into translational control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its basal role in translation initiation, MNK2 is a critical mediator of oncogenic mRNA translation in several malignancies. Phosphorylation of eIF4E via MNK2 contributes to oncogenic protein synthesis in contexts such as diffuse large B‐cell lymphoma, where MNK kinases adjust the balance between eIF4E family members, as well as in medulloblastoma and leukemia where MNK2‐dependent feedback mechanisms (for example, in response to mTORC1 inhibition by rapamycin) promote cell survival and drug resistance. In pancreatic cancer, MNK2 has been identified as a driver of chemoresistance, underscoring the impact of aberrant eIF4E phosphorylation on disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMNK2’s function extends to the regulation of alternative splicing and integration with key signaling pathways in diverse cancers. In colon cancer and glioblastoma, splicing factors such as RBM25 direct the production of oncogenic (Mnk2b) or tumor suppressive (Mnk2a) isoforms, while in non‐small cell lung cancer, overexpression of MNK2 correlates with enhanced ERK/AKT signaling, increased eIF4E phosphorylation, and aggressive tumor behavior. Moreover, crosstalk with mTORC1—where direct phosphorylation of MNK2 (for instance, at Ser74) modulates its interaction with eIF4G and downstream oncogenic signaling—has been implicated in prostate cancer progression, soft tissue sarcoma, and ovarian cancer chemoresistance. MNK2 is also expressed in neuronal populations, suggesting broader physiological roles, and its interaction with ubiquitin ligase complexes (including those containing VHL) may further influence cell morphology and homeostasis. Collectively, these findings position MNK2 as a central regulator of translational control whose dysregulation contributes to oncogenesis and resistance to therapeutic interventions, thereby representing a promising target for combination treatments in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gert C Scheper, Josep L Parra, Mary Wilson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.16.5692-5705.2003"}], "href": "https://doi.org/10.1128/MCB.23.16.5692-5705.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12897141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12897141"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pingzhang Wang, Xin Wang, Feng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci China C Life Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11427-006-0265-5"}], "href": "https://doi.org/10.1007/s11427-006-0265-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16856496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16856496"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sonali Joshi, Bhumika Sharma, Surinder Kaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.197921"}], "href": "https://doi.org/10.1074/jbc.M110.197921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21149447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21149447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L Adesso, S Calabretta, F Barbagallo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.306"}], "href": "https://doi.org/10.1038/onc.2012.306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22797067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22797067"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.476192"}], "href": "https://doi.org/10.1074/jbc.M113.476192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23814052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23814052"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rebecca L Stead, Christopher G Proud "}, {"type": "b", "children": [{"type": "t", "text": "Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2013.06.045"}], "href": "https://doi.org/10.1016/j.febslet.2013.06.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23831578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23831578"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2319"}], "href": "https://doi.org/10.18632/oncotarget.2319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25193863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25193863"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ari L Landon, Parameswary A Muniandy, Amol C Shetty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6413"}], "href": "https://doi.org/10.1038/ncomms6413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25403230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25403230"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Theodosia Teo, Mingfeng Yu, Yuchao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.12.029"}], "href": "https://doi.org/10.1016/j.canlet.2014.12.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25527453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25527453"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaodi Su, Yingpu Yu, Yi Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3205"}], "href": "https://doi.org/10.1038/ni.3205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26147685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26147685"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nadejda L Korneeva, Anren Song, Hermann Gram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.694190"}], "href": "https://doi.org/10.1074/jbc.M115.694190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26668315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26668315"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andrew K Kwegyir-Afful, Robert D Bruno, Puranik Purushottamachar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13895"}], "href": "https://doi.org/10.1111/febs.13895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27618366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27618366"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhihua Guo, Guilin Peng, Ermao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-10397-9"}], "href": "https://doi.org/10.1038/s41598-017-10397-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28878291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28878291"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Maxim Mogilevsky, Odelia Shimshon, Saran Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky921"}], "href": "https://doi.org/10.1093/nar/gky921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30329087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30329087"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jianling Xie, Kaikai Shen, Ashley T Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-020-03491-1"}], "href": "https://doi.org/10.1007/s00018-020-03491-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32170339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32170339"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01661-4"}], "href": "https://doi.org/10.1038/s41388-021-01661-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33564073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33564073"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jing Wang, Chaoling Da, Ye Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.02.084"}], "href": "https://doi.org/10.1016/j.bbrc.2021.02.084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33836345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33836345"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Stephanie Shiers, James J Sahn, Theodore J Price "}, {"type": "b", "children": [{"type": "t", "text": "MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2023.01.039"}], "href": "https://doi.org/10.1016/j.neuroscience.2023.01.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36764601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36764601"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Lili Zhi, Chaoqun Chen, Ge Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci China Life Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11427-023-2582-x"}], "href": "https://doi.org/10.1007/s11427-023-2582-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39110401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39110401"}]}]}]}
Synonyms	MNK2
Proteins	MKNK2_HUMAN
NCBI Gene ID	2872
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MKNK2 has 9,962 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 125 datasets.

Click the + buttons to view associations for MKNK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MKNK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MKNK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MKNK2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MKNK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MKNK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MKNK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MKNK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MKNK2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MKNK2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MKNK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MKNK2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MKNK2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MKNK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MKNK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MKNK2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MKNK2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MKNK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MKNK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MKNK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MKNK2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MKNK2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MKNK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MKNK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MKNK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MKNK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MKNK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MKNK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MKNK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MKNK2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MKNK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MKNK2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MKNK2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for MKNK2 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MKNK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MKNK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MKNK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MKNK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MKNK2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MKNK2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MKNK2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MKNK2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.