HGNC Family | Basic helix-loop-helix proteins (BHLH) |
Name | MLX interacting protein |
Description | This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMLXIP, which encodes the transcription factor MondoA, functions as a nutrient sensor that detects intracellular glucose metabolites—most notably glucose‐6‐phosphate—and thereby governs a critical metabolic feedback loop. In resting cells, MondoA is tethered at the outer mitochondrial membrane; when glucose or analogous hexoses (and even conditions such as acidosis) elevate glucose‐6‐phosphate levels, MondoA shuttles to the nucleus and directly activates genes (for example, thioredoxin-interacting protein [TXNIP] and key glycolytic enzymes) that subsequently act to restrain glucose uptake. This multi‐step regulation requires both hexokinase activity and additional signals that enable promoter occupancy and coactivator recruitment, thus integrating mitochondrial energy status with nuclear gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond maintaining energy homeostasis in normal tissues, MLXIP plays a pivotal role in metabolic reprogramming during oncogenesis and in settings of nutrient excess. MondoA collaborates with oncogenic drivers—such as Myc—to reprogram pathways that encompass lipid biosynthesis, oxidative phosphorylation, and insulin signaling. Studies in acute lymphoblastic leukemia, cervical cancer, and even in specialized immune subsets like intratumoral regulatory T cells have revealed that aberrant expression of MondoA fosters enhanced glycolysis and survival under metabolic stress. Moreover, its activity is modulated by key intracellular signals including mTOR, which can restrict or permit nuclear accumulation and transcriptional activity. Such molecular interplay underscores the therapeutic potential of targeting MLXIP‐directed circuits in a range of malignancies and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPhylogenomic analyses further underscore the evolutionary conservation of MLXIP, indicating that MondoA mediates an ancient and fundamental role in glucose metabolism across vertebrates. In broader clinical contexts, investigations of related transcriptional networks have associated polymorphisms in MLXIPL—as well as alterations in MLXIP expression—with phenotypes ranging from coronary artery disease to hip osteoarthritis, suggesting that the regulatory functions of these networks extend into cardiovascular and musculoskeletal health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alanna L Eilers, Eleanor Sundwall, Monica Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.24.8514-8526.2002"}], "href": "https://doi.org/10.1128/MCB.22.24.8514-8526.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12446771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12446771"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christopher L Sans, Daniel J Satterwhite, Carrie A Stoltzman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00657-05"}], "href": "https://doi.org/10.1128/MCB.00657-05"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16782875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16782875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Carrie A Stoltzman, Christopher W Peterson, Kevin T Breen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0712199105"}], "href": "https://doi.org/10.1073/pnas.0712199105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18458340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18458340"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mohan R Kaadige, Ryan E Looper, Sadhaasivam Kamalanaadhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0901221106"}], "href": "https://doi.org/10.1073/pnas.0901221106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706488"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christopher W Peterson, Carrie A Stoltzman, Michael P Sighinolfi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01613-09"}], "href": "https://doi.org/10.1128/MCB.01613-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20385767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20385767"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julia Ling-Yu Chen, Daniel Merl, Christopher W Peterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1001093"}], "href": "https://doi.org/10.1371/journal.pgen.1001093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20844768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20844768"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Carrie A Stoltzman, Mohan R Kaadige, Christopher W Peterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.275503"}], "href": "https://doi.org/10.1074/jbc.M111.275503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21908621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21908621"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Caroline M Wernicke, Günther H S Richter, Beate C Beinvogl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2012.05.009"}], "href": "https://doi.org/10.1016/j.leukres.2012.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22748921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22748921"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yasuyoshi Kanari, Yuki Sato, Satoru Aoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0059026"}], "href": "https://doi.org/10.1371/journal.pone.0059026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23520550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23520550"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mohan R Kaadige, Jingye Yang, Blake R Wilde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00636-14"}], "href": "https://doi.org/10.1128/MCB.00636-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25332233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25332233"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Patrick A Carroll, Daniel Diolaiti, Lisa McFerrin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2014.11.024"}], "href": "https://doi.org/10.1016/j.ccell.2014.11.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25640402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25640402"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Parmveer Singh, David M Irwin "}, {"type": "b", "children": [{"type": "t", "text": "Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0149682"}], "href": "https://doi.org/10.1371/journal.pone.0149682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26910886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26910886"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Byungyong Ahn, Mangala M Soundarapandian, Hampton Sessions, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI87382"}], "href": "https://doi.org/10.1172/JCI87382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27500491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27500491"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Paul Richards, Latif Rachdi, Masaya Oshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db17-0595"}], "href": "https://doi.org/10.2337/db17-0595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29282201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29282201"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Blake R Wilde, Zhizhou Ye, Tian-Yeh Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.40199"}], "href": "https://doi.org/10.7554/eLife.40199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30717828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30717828"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Byungyong Ahn, Shibiao Wan, Natasha Jaiswal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA drives muscle lipid accumulation and insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.129119"}], "href": "https://doi.org/10.1172/jci.insight.129119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31287806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31287806"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Junhua Zhang, Xingbo Tian, Huifang Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvz105"}], "href": "https://doi.org/10.1093/jb/mvz105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31782782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31782782"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ying Lu, Yangyang Li, Qi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2021.04.041"}], "href": "https://doi.org/10.1053/j.gastro.2021.04.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33901495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33901495"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alexandra Sipol, Erik Hameister, Busheng Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2020007932"}], "href": "https://doi.org/10.1182/blood.2020007932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33908607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33908607"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Asghar Ghasemi, Hasan Aghajani, Soudabeh Fallah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anatol J Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5152/akd.2014.5135"}], "href": "https://doi.org/10.5152/akd.2014.5135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25179879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25179879"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Chuan Chen, Desheng Kong, Pin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LMX1B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MLXIP"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " are associated with hip osteoarthritis in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/17520363.2024.2389030"}], "href": "https://doi.org/10.1080/17520363.2024.2389030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39263770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39263770"}]}]}]}
|
Synonyms | BHLHE36, MONDOA, MIR |
Proteins | MLXIP_HUMAN |
NCBI Gene ID | 22877 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
MLXIP has 5,888 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.
Click the + buttons to view associations for MLXIP from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MLXIP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MLXIP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MLXIP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MLXIP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MLXIP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MLXIP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with MLXIP protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with MLXIP gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MLXIP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of MLXIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MLXIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MLXIP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MLXIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing MLXIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MLXIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MLXIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing MLXIP protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MLXIP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with MLXIP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with MLXIP gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with MLXIP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with MLXIP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MLXIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MLXIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with MLXIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with MLXIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MLXIP gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MLXIP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of MLXIP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MLXIP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with MLXIP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MLXIP from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MLXIP gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding MLXIP protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving MLXIP gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving MLXIP gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving MLXIP gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing MLXIP protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing MLXIP protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing MLXIP protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by MLXIP gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by MLXIP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by MLXIP gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of MLXIP gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MLXIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MLXIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GWAS Catalog SNP-Phenotype Associations | phenotypes associated with MLXIP gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of MLXIP gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of MLXIP protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for MLXIP from the curated Hub Proteins Protein-Protein Interactions dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for MLXIP protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MLXIP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate MLXIP protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MLXIP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MLXIP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with MLXIP gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MLXIP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MLXIP gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of MLXIP gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MLXIP gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MLXIP protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MLXIP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting MLXIP gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MLXIP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MLXIP gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of MLXIP gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing MLXIP protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for MLXIP from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MLXIP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MLXIP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving MLXIP protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving MLXIP protein from the Wikipathways PFOCR 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MLXIP gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MLXIP gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MLXIP gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MLXIP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MLXIP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MLXIP gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MLXIP gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MLXIP gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of MLXIP gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of MLXIP gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MLXIP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MLXIP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MLXIP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MLXIP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MLXIP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MLXIP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MLXIP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MLXIP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
Virus MINT Protein-Viral Protein Interactions | interacting viral proteins for MLXIP from the Virus MINT Protein-Viral Protein Interactions dataset. | |
Virus MINT Protein-Virus Interactions | viruses interacting with MLXIP from the Virus MINT Protein-Virus Interactions dataset. | |
WikiPathways Pathways 2024 | pathways involving MLXIP protein from the WikiPathways Pathways 2024 dataset. | |