MMP11 Gene

HGNC Family	Metzincin metallopeptidases
Name	matrix metallopeptidase 11
Description	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMatrix metalloproteinase‑11 (MMP11), also known as stromelysin‑3, functions as a key extracellular protease that remodels the tumor microenvironment by processing specific matrix components. In several studies, MMP11 has been identified as a target of tumor‑suppressive microRNAs—for example, downregulation of miR‑125a in hepatocellular carcinoma is associated with an increase in MMP11 expression, suggesting a role in hepatocellular carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, analyses in liver tumors further reveal that reduced miR‑125a expression is linked with upregulation of MMP11, while mechanistic studies indicate that MMP11 mediates the proteolytic cleavage of the native α3 chain of collagen VI, a process essential for correct collagen folding and tissue cohesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of tumor progression, MMP11 appears to promote malignant behaviors by facilitating cell migration and invasion. For instance, exosome‐mediated delivery of MMP11 from cancer‐associated fibroblasts to gastric cancer cells enhances cellular motility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while other studies have reported dual roles for MMP11—on one hand it stimulates tumor cell migration and inhibits apoptosis, and on the other, in some animal models, it has been implicated in suppression of metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In triple‑negative breast cancer, suppression of MMP11 by miR‑145 reduces invasion, and in gastric adenocarcinoma, shRNA‑mediated knockdown of MMP11 leads to decreased proliferation and invasion, findings that underscore its pro‑invasive properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, overexpression of MMP11 has been associated with poor prognostic features in several cancers. Although in some ovarian carcinomas MMP11 overexpression did not correlate with survival outcomes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", in other malignancies, including breast cancer and various solid tumors, elevated levels of MMP11 serve as a biomarker for aggressive disease and poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qian Bi, Shanhong Tang, Lin Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040169"}], "href": "https://doi.org/10.1371/journal.pone.0040169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22768249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22768249"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vinayakumar Siragam, Zina Jeyapalan Rutnam, Weining Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.717"}], "href": "https://doi.org/10.18632/oncotarget.717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23211491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23211491"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "E R Motrescu, S Blaise, N Etique, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.218"}], "href": "https://doi.org/10.1038/onc.2008.218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18622425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18622425"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nicola Coppola, Giorgio de Stefano, Marta Panella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase-11, and c-Raf."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15809"}], "href": "https://doi.org/10.18632/oncotarget.15809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28445974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28445974"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guifang Xu, Bin Zhang, Jiahui Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.33750"}], "href": "https://doi.org/10.7150/ijbs.33750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31595150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31595150"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xu Zhang, Shuai Huang, Junchao Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics (Review)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3400"}], "href": "https://doi.org/10.3892/ijo.2016.3400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26892540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26892540"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "L Tang, D Wei, F Yan "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cgt.2016.27"}], "href": "https://doi.org/10.1038/cgt.2016.27"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27364572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27364572"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y-B Kou, S-Y Zhang, B-L Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of MMP11 inhibits proliferation and invasion of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Immunopathol Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/039463201302600209"}], "href": "https://doi.org/10.1177/039463201302600209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23755751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23755751"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chung-Han Hsin, Ying-Erh Chou, Shun-Fa Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MMP-11 promoted the oral cancer migration and Fak/Src activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15824"}], "href": "https://doi.org/10.18632/oncotarget.15824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28427180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28427180"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Martine Périgny, Isabelle Bairati, Isabelle Harvey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1309/49LA9XCBGWJ8F2KM"}], "href": "https://doi.org/10.1309/49LA9XCBGWJ8F2KM"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18208802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18208802"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Giuseppe Roscilli, Manuela Cappelletti, Claudia De Vitis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-12-54"}], "href": "https://doi.org/10.1186/1479-5876-12-54"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24564996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24564996"}]}]}]}
Synonyms	ST3, STMY3, SL-3
Proteins	MMP11_HUMAN
NCBI Gene ID	4320
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MMP11 has 8,179 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for MMP11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MMP11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MMP11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MMP11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MMP11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MMP11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MMP11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MMP11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MMP11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MMP11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MMP11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MMP11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MMP11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MMP11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MMP11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MMP11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MMP11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MMP11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MMP11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MMP11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MMP11 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MMP11 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MMP11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MMP11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MMP11 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MMP11 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MMP11 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MMP11 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MMP11 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MMP11 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.