MMP17 Gene

HGNC Family	Metzincin metallopeptidases
Name	matrix metallopeptidase 17 (membrane-inserted)
Description	This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMT4‐MMP (also known as MMP17) is a glycosylphosphatidyl inositol‐anchored metalloproteinase that plays a pivotal role in pericellular proteolysis and extracellular matrix (ECM) remodeling. It can activate other proteases—as exemplified by its ability to process ADAMTS‐4 into an active form capable of cleaving aggrecan—and is expressed in various cell types such as eosinophils, where its expression is upregulated by pro‐inflammatory cytokines (e.g., TNF‐α). Biochemical studies have demonstrated that MT4‐MMP exists in multiple forms (monomers, dimers, and oligomers) concentrated in lipid rafts, and that specific domains (including a cysteine‐rich stem and the hemopexin domain) govern its homodimerization, processing, and stability at the cell surface."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, MT4‐MMP is often upregulated under hypoxic conditions via HIF‐1α and the EMT regulator SLUG, contributing significantly to tumor progression. Its increased expression enhances tumor cell proliferation through modulation of cell cycle regulators and growth factor receptor pathways (including CDK4 activation and EGFR phosphorylation) and promotes metastasis by stimulating invadopodia formation, vascular destabilization, and increased intravasation of tumor cells. These multifaceted actions establish MT4‐MMP as an important mediator of matrix degradation and angiogenic switching, processes that underpin the metastatic cascade in various malignancies such as breast, head and neck, and triple‐negative breast cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor progression, MT4‐MMP is also implicated in non‐malignant pathologies. For example, in vascular disease, its deficiency has been associated with altered monocyte adhesion, enhanced macrophage accumulation, and overall modulation of early atherosclerotic lesion development, suggesting a role in vascular remodeling. In addition, aberrant expression of MT4‐MMP has emerged as a potential biomarker in ovarian cancer—where high levels correlate with increased ECM degradation and poorer clinical outcomes—and is under investigation in other conditions such as thyroid nodules and prostatic tissue remodeling. Collectively, these findings support a broad functional spectrum for MT4‐MMP in both physiological tissue homeostasis and the pathological processes of cancer and vascular diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gui Gao, Anna Plaas, Vivian P Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312100200"}], "href": "https://doi.org/10.1074/jbc.M312100200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14701864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14701864"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marie-Christine Gauthier, Christine Racine, Claudine Ferland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1357-2725(03)00136-5"}], "href": "https://doi.org/10.1016/s1357-2725(03"}, {"type": "t", "text": "00136-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12962706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12962706"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anjum Sohail, Marta Marco, Huiren Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.253369"}], "href": "https://doi.org/10.1074/jbc.M111.253369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21828052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21828052"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Susan J Atkinson, Christian Roghi, Gillian Murphy "}, {"type": "b", "children": [{"type": "t", "text": "MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20060243"}], "href": "https://doi.org/10.1042/BJ20060243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16686598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16686598"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chi-Hung Huang, Wen-Hao Yang, Shyue-Yih Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.91326"}], "href": "https://doi.org/10.1593/neo.91326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20019845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20019845"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vincent Chabottaux, Stéphanie Ricaud, Laurent Host, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2009.00764.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2009.00764.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19426156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19426156"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alexandra Paye, Alice Truong, Cassandre Yip, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2017.23"}], "href": "https://doi.org/10.1038/bjc.2017.23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28196064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28196064"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of MMP17 predicts poor clinical outcomes in epithelial ovarian cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000030279"}], "href": "https://doi.org/10.1097/MD.0000000000030279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36042626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36042626"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bettina Hieronimus, Julian Pfohl, Christian Busch, et al. 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Synonyms	MMP-17, MT4MMP, MT4-MMP, MTMMP4
Proteins	MMP17_HUMAN
NCBI Gene ID	4326
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MMP17 has 5,199 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for MMP17 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MMP17 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP17 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP17 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MMP17 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MMP17 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MMP17 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP17 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP17 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP17 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP17 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MMP17 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP17 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP17 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MMP17 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP17 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MMP17 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MMP17 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MMP17 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MMP17 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MMP17 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MMP17 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MMP17 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP17 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MMP17 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MMP17 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MMP17 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MMP17 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MMP17 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MMP17 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MMP17 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MMP17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MMP17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MMP17 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MMP17 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP17 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MMP17 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MMP17 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MMP17 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MMP17 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP17 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MMP17 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.