MMP24 Gene

HGNC Family	Metzincin metallopeptidases
Name	matrix metallopeptidase 24 (membrane-inserted)
Description	This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMMP24, also known as membrane‐type 5 matrix metalloproteinase (MT5‐MMP), is highly expressed in the central nervous system, where it contributes to neurodevelopment and synaptic plasticity. Analysis of human neuronal models and adult hippocampal tissue revealed not only elevated levels of MMP24 transcript in differentiated neurons but also the existence of an alternate variant, suggesting a complex role in brain tissue remodeling. In Alzheimer’s disease models, MMP24 has been shown to control the processing of the amyloid precursor protein (APP), thereby influencing amyloid beta (Aβ) generation through proteolytic and non‐proteolytic mechanisms—including activation by the serine proteinase PCSK6—which highlights its potential as a therapeutic target in neurodegenerative conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncological contexts, MMP24 functions as a critical effector of metastasis. In lung and gastric cancers, inactivation of the transcriptional repressor CIC relieves suppression of the effector ETV4, which in turn upregulates MMP24—a necessary and sufficient event for tumor invasion and metastatic dissemination. Furthermore, studies in non‐small cell lung cancer have revealed that the expression level of MMP24 in patient blood and tumor tissue changes dynamically over the course of disease and treatment, while RNA interference strategies targeting MMP24 significantly reduce the invasive capacity of ovarian cancer cells. These findings collectively underscore the enzyme’s importance as both a biomarker of tumor progression and a potential target for anti‐metastatic therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in disease, genetic investigations have implicated MMP24 in developmental processes. A genome‐wide association study of diverse populations identified single nucleotide polymorphisms in the MMP24 gene as among the variants most strongly associated with height, suggesting that MMP24 may also influence human growth and developmental regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heather H Ross, Helen L Fillmore "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2007.11.074"}], "href": "https://doi.org/10.1016/j.febslet.2007.11.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18062926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18062926"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laura García-González, Jean-Michel Paumier, Laurence Louis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202100593R"}], "href": "https://doi.org/10.1096/fj.202100593R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34117802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34117802"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nikita Arnst, Pedro Belio-Mairal, Laura García-González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10071705"}], "href": "https://doi.org/10.3390/cells10071705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34359875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34359875"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mingliang Xu, Junjie Li, Lei Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2024.114688"}], "href": "https://doi.org/10.1016/j.expneurol.2024.114688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38216110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38216110"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ya-ping Luo, Mei Zhong, Li-ping Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Inhibitory effects of RNA interference on MMP-24 expression and invasiveness of ovarian cancer SKOV(3) cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19403421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19403421"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ross A Okimoto, Frank Breitenbuecher, Victor R Olivas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of Capicua drives cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3728"}], "href": "https://doi.org/10.1038/ng.3728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27869830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27869830"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jacek Pietrzak, Dagmara Szmajda-Krygier, Agnieszka Wosiak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2021.112559"}], "href": "https://doi.org/10.1016/j.biopha.2021.112559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35062057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35062057"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eveline Gadelha Pereira Fontenele, Maria Elisabete Amaral de Moraes, Catarina Brasil d'Alva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association Study of GWAS-Derived Loci with Height in Brazilian Children: Importance of MAP3K3, MMP24 and IGF1R Polymorphisms for Height Variation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Res Paediatr (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000437324"}], "href": "https://doi.org/10.1159/000437324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26304632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26304632"}]}]}]}
Synonyms	MT-MMP 5, MT5MMP, MMP25, MT5-MMP, MT-MMP5, MMP-24, MTMMP5
Proteins	MMP24_HUMAN
NCBI Gene ID	10893
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MMP24 has 6,506 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for MMP24 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MMP24 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MMP24 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMP24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MMP24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MMP24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MMP24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP24 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP24 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMP24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MMP24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MMP24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MMP24 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP24 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MMP24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MMP24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MMP24 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MMP24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MMP24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MMP24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MMP24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MMP24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MMP24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMP24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MMP24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MMP24 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MMP24 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MMP24 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MMP24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MMP24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MMP24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MMP24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MMP24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MMP24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MMP24 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MMP24 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMP24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MMP24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MMP24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MMP24 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.