{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMN1 functions prominently as an oncogenic driver in a variety of hematologic malignancies. Studies in acute myeloid leukemia (AML), T‐cell leukemias, and B‐cell acute lymphoblastic leukemia have demonstrated that high-level MN1 expression, or its fusion derivatives (e.g. MN1–TEL, MN1–ETV6), promotes proliferation, enhances self‐renewal and impairs differentiation of hematopoietic progenitors. In murine models, enforced expression of wild‐type MN1 or its fusion oncoproteins rapidly induces lethal leukemia that is resistant to differentiation cues such as all‐trans retinoic acid (ATRA) and is associated with adverse clinical outcomes. In patients, elevated MN1 expression correlates with poor remission rates, shorter survival, and increased relapse risk and it cooperates with leukemogenic programs—often involving HOX genes—to expand the leukemia‐initiating cell population."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‐hematopoietic contexts, MN1 acts as a transcriptional coactivator modulating key signaling pathways. In osteoblasts, 1,25‐dihydroxyvitamin D₃ induces MN1 expression, which in turn selectively enhances vitamin D receptor–mediated transcription and imparts an antiproliferative effect by delaying S‐phase entry. Similarly, MN1 can regulate target promoters such as that of IGFBP5 through specific CACCC elements and interact with retinoic acid‐responsive pathways, underscoring its dual capacity to either stimulate or repress gene transcription in a context‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nApart from its role in cancer, MN1 is critical for normal developmental processes—most notably in the craniofacial region and brain. De novo truncating mutations or deletions affecting the C‐terminal region of MN1 cause a distinct syndrome characterized by intellectual disability, craniofacial dysmorphism, midface hypoplasia and, in some cases, cerebellar malformations. These findings support a model in which enhanced stability and aberrant interactions of the mutant, truncated MN1 protein (sometimes described as MN1 C‐terminal truncation syndrome) disrupt normal transcriptional regulation during craniofacial and brain development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMN1 alterations have also been implicated in central nervous system tumors. Rearrangements involving MN1 (frequently resulting in MN1–BEND2 fusions) appear in astroblastomas and related ependymal tumors, where they associate with distinct DNA methylation profiles and prognostic outcomes. In addition, MN1 overexpression in certain gliomas correlates with lower grade and improved survival, suggesting that in the neural context the level or nature of MN1 alteration can have divergent biologic and clinical implications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, in other solid tumors, MN1 expression has emerged as a prognostic marker. Elevated MN1 levels in colorectal cancer, for example, are associated with aggressive tumor behavior and poorer outcomes, while its role in certain soft‐tissue tumors such as malignant peripheral nerve sheath tumors and osteosarcomas further suggests that aberrant MN1 expression or function may contribute to oncogenesis beyond the hematopoietic system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "34", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroyuki Kawagoe, Gerard C Grosveld "}, {"type": "b", "children": [{"type": "t", "text": "Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-04-1679"}], "href": "https://doi.org/10.1182/blood-2005-04-1679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16105979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16105979"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael Heuser, Bob Argiropoulos, Florian Kuchenbauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-03-080523"}], "href": "https://doi.org/10.1182/blood-2007-03-080523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17494859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17494859"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C Carella, J Bonten, S Sirma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 overexpression is an important step in the development of inv(16) AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2404778"}], "href": "https://doi.org/10.1038/sj.leu.2404778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525718"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christian Langer, Guido Marcucci, Kelsi B Holland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2008.20.6110"}], "href": "https://doi.org/10.1200/JCO.2008.20.6110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19451432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19451432"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "T Liu, D Jankovic, L Brault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2009.272"}], "href": "https://doi.org/10.1038/leu.2009.272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20072157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20072157"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sebastian Schwind, Guido Marcucci, Jessica Kohlschmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-06-357764"}], "href": "https://doi.org/10.1182/blood-2011-06-357764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21828125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21828125"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-012-1457-7"}], "href": "https://doi.org/10.1007/s00277-012-1457-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22488406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22488406"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Timothy S Pardee "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0043185"}], "href": "https://doi.org/10.1371/journal.pone.0043185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22905229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22905229"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Salah Aref, Lamiaa Ibrahim, Hana Morkes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meningioma 1 (MN1) expression: refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hematology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1179/1607845412Y.0000000065"}], "href": "https://doi.org/10.1179/1607845412Y.0000000065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23394438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23394438"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jeroen Breckpot, Britt-Marie Anderlid, Yasemin Alanay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosome 22q12.1 microdeletions: confirmation of the MN1 gene as a candidate gene for cleft palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.65"}], "href": "https://doi.org/10.1038/ejhg.2015.65"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25944382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25944382"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Masashi Numata, Mehmet Deniz Yener, Sema Sırma Ekmekçi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2015.05.013"}], "href": "https://doi.org/10.1016/j.leukres.2015.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26111797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26111797"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Simone S Riedel, Jessica N Haladyna, Matthew Bezzant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI80825"}], "href": "https://doi.org/10.1172/JCI80825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26927674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26927674"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sonia Carturan, Jessica Petiti, Valentina Rosso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variable but consistent pattern of Meningioma 1 gene (MN1) expression in different genetic subsets of acute myelogenous leukaemia and its potential use as a marker for minimal residual disease detection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12269"}], "href": "https://doi.org/10.18632/oncotarget.12269"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27765915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27765915"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rania A Zayed, Maha A Eltaweel, Shahira K A Botros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 and PTEN gene expression in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-160235"}], "href": "https://doi.org/10.3233/CBM-160235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27983532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27983532"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Haigang Shao, Jiannong Cen, Suning Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-017-3208-2"}], "href": "https://doi.org/10.1007/s00277-017-3208-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29273914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29273914"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2018.211201"}], "href": "https://doi.org/10.3324/haematol.2018.211201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31413090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31413090"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Irena Marjanovic, Teodora Karan-Djurasevic, Tatjana Kostic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of combined BAALC and MN1 gene expression level in acute myeloid leukemia with normal karyotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Lab Hematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ijlh.13405"}], "href": "https://doi.org/10.1111/ijlh.13405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33242229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33242229"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Aparna Ningombam, Deepak Verma, Rajive Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2024.25.7.2283"}], "href": "https://doi.org/10.31557/APJCP.2024.25.7.2283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39068559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39068559"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Amelia L M Sutton, Xiaoxue Zhang, Tara I Ellison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0081"}], "href": "https://doi.org/10.1210/me.2005-0081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15890672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15890672"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Magda A Meester-Smoor, Marjolein J F W Janssen, Gerard C Grosveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgn168"}], "href": "https://doi.org/10.1093/carcin/bgn168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18632758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18632758"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rudolf Reiter, Sibylle Brosch, Manuel Lüdeke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and environmental risk factors for submucous cleft palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Oral Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0722.2012.00948.x"}], "href": "https://doi.org/10.1111/j.1600-0722.2012.00948.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22409215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22409215"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Norman L Lehman, Aisulu Usubalieva, Tong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-019-0689-3"}], "href": "https://doi.org/10.1186/s40478-019-0689-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30876455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30876455"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Caroline Bosson, Françoise Devillard, Véronique Satre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37450"}], "href": "https://doi.org/10.1002/ajmg.a.37450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26545049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26545049"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Christopher C Y Mak, Dan Doherty, Angela E Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awz379"}], "href": "https://doi.org/10.1093/brain/awz379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31834374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31834374"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Noriko Miyake, Hidehisa Takahashi, Kazuyuki Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2019.11.011"}], "href": "https://doi.org/10.1016/j.ajhg.2019.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31839203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31839203"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Madlen Jentzsch, Marius Bill, Juliane Grimm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-020-04235-8"}], "href": "https://doi.org/10.1007/s00277-020-04235-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32862286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32862286"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Arman Zhao, Dandan Shu, Daxue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel truncating variant of MN1 penultimate exon identified in a Chinese patient with newly recognized MN1 C-terminal truncation syndrome: Case report and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jdn.10154"}], "href": "https://doi.org/10.1002/jdn.10154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34708882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34708882"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jing Jia Yu, Qiu Yi Wu, Qiu Chi Ran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinctive Craniofacial and Oral Anomalies in MN1 C-terminal Truncation Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin J Dent Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3290/j.cjdr.b5128655"}], "href": "https://doi.org/10.3290/j.cjdr.b5128655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38546519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38546519"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Syeda Iqra Hussain, Nazif Muhammad, Shahbaz Ali Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in HCFC1 and MN1 genes causing intellectual disability in two Pakistani families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-024-01943-2"}], "href": "https://doi.org/10.1186/s12920-024-01943-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38956580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38956580"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Masum Saini, Ajaya Nand Jha, Rajiv Tangri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MN1 overexpression with varying tumor grade is a promising predictor of survival of glioma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa231"}], "href": "https://doi.org/10.1093/hmg/ddaa231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33105486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33105486"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Masaki Ujihara, Kazuhiko Mishima, Atsushi Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique pathological findings of astroblastoma with MN1 alteration in a patient with late recurrence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Tumor Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10014-021-00401-6"}], "href": "https://doi.org/10.1007/s10014-021-00401-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33913040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33913040"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Simone S Riedel, Congcong Lu, Hongbo M Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.04.014"}], "href": "https://doi.org/10.1016/j.molcel.2021.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33974912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33974912"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Norman L Lehman "}, {"type": "b", "children": [{"type": "t", "text": "Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral tumor of female children with a good prognosis that is distinct from classical astroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-022-04222-1"}], "href": "https://doi.org/10.1007/s11060-022-04222-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36604386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36604386"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yi-Jung Ho, Feng-Cheng Liu, Jungshan Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of meningioma 1 is correlated with reduced survival rates in colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Histochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.acthis.2019.05.006"}], "href": "https://doi.org/10.1016/j.acthis.2019.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31133374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31133374"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Izumi Kinoshita, Yuichi Yamada, Kenichi Kohashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent MN1 Gene Mutations in Malignant Peripheral Nerve Sheath Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.14642"}], "href": "https://doi.org/10.21873/anticanres.14642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33109559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33109559"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Hong-Bo Li, Gang Huang, Jian Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2022.104142"}], "href": "https://doi.org/10.1016/j.ebiom.2022.104142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35810559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35810559"}]}]}]}