{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMORC2 encodes an ATPase-dependent chromatin remodeler that plays a pivotal role in the maintenance of genomic integrity. In response to DNA damage, MORC2 is post‐translationally modified – for example, phosphorylated by kinases such as p21‐activated kinase 1 and PARylated by PARP1 – which stimulates its ATPase activity to remodel chromatin and promote efficient recruitment of DNA repair factors. Furthermore, MORC2 forms homodimers and associates with the HUSH complex to enforce epigenetic silencing, thereby regulating transcription in a manner critical for genome stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various human cancers, MORC2 functions as a potent oncogene by reprogramming transcription and metabolic pathways to favor tumor progression. Within the nucleus, it recruits chromatin modifiers such as SIRT1, EZH2, and interacts with factors that downregulate tumor suppressors (including p21, NDRG1, and ArgBP2) while promoting cell cycle progression, epithelial–mesenchymal transition, invasion, and metastasis. In the cytosol, MORC2 can interact with metabolic enzymes like ATP–citrate lyase (ACLY) and modulate glucose metabolism via the MYC/MAX axis, linking metabolic adaptation with aggressive cancer phenotypes. Its ability to regulate alternative splicing events further contributes to the metastatic behavior observed in cancers such as triple‐negative breast cancer, colorectal cancer, gastric cancer, liver cancer, cholangiocarcinoma, glioma, and lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogenic mutations in MORC2 have been linked to a diverse spectrum of neuropathies, including axonal Charcot–Marie–Tooth disease and related neurodevelopmental disorders. 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