MORC3 Gene

HGNC Family	Zinc fingers
Name	MORC family CW-type zinc finger 3
Description	This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMORC3, also known as NXP2, is a multifunctional nuclear regulator that plays pivotal roles in chromatin organization, transcriptional control, and the induction of cellular senescence. Early work characterized MORC3 as a nuclear matrix‐associated protein containing an ATPase and a CW‐type zinc-finger domain, enabling binding to methylated histone H3 tails and targeting to chromatin (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "‑). Subsequent studies demonstrated that when tethered to promoters, MORC3 can repress transcription, consistent with its function in SUMO-mediated gene repression (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "‑). Moreover, MORC3 is important for cellular senescence by facilitating the recruitment and activation of the tumor suppressor p53 within promyelocytic leukemia nuclear bodies (PML-NBs) (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "‑). Its intrinsic ATPase activity is tightly regulated by an intramolecular interaction with its CW domain—which not only directs binding to methylated histones but also autoinhibits the ATPase—thereby serving as a molecular clamp whose activity can be modulated, including by viral proteins (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "‑). In addition, MORC3 has been shown to regulate chromatin structure by orchestrating Daxx-mediated incorporation of histone H3.3 at endogenous retroviral loci, contributing to transcriptional silencing (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "‑).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMORC3 exerts significant antiviral functions by serving as a host restriction factor that is actively involved in mounting intrinsic immune defenses against diverse viruses. During herpes simplex virus type 1 (HSV-1) infection, MORC3 is recruited to nuclear sites associated with incoming viral genomes where it helps to assemble antiviral nuclear domains containing proteins such as PML, Sp100, and γH2AX; however, HSV-1’s virulence factor ICP0 targets MORC3 for degradation to subvert this defense (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "‑). In a broader context, MORC3 operates within a “self-guarded” immune pathway where its degradation releases an otherwise repressed antiviral type I interferon response independent of canonical IRF3/IRF7 signalling (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "‑). In influenza A virus infections, MORC3 interacts with viral polymerase and ribonucleoprotein (RNP) complexes to promote viral transcription, with its depletion leading to a marked reduction in viral gene expression (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "‑). Similarly, during human cytomegalovirus (HCMV) infection, MORC3 suppresses immediate-early gene expression via repression of the major immediate early promoter (MIEP), although the virus transiently depletes MORC3 through proteasomal degradation to facilitate a productive infection or reactivation from latency (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "‑).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in nuclear homeostasis and antiviral defense, MORC3 is a clinically important autoantigen in idiopathic inflammatory myopathies such as dermatomyositis. Autoantibodies directed against MORC3/NXP2 have been identified in both juvenile and adult patients, with their presence correlating with distinct clinical subtypes, an increased risk of cancer, and the development of interstitial lung disease. Multiple serological studies support the utility of anti-MORC3 (anti-NXP2) antibody testing as a diagnostic tool to stratify patients and predict clinical outcomes in these disorders (‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "‑, ‑"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "‑).\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yukio Kimura, Fumie Sakai, Osami Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201440200"}], "href": "https://doi.org/10.1074/jbc.M201440200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11927593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11927593"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Adam Rosendorff, Shuhei Sakakibara, Sixin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0601066103"}], "href": "https://doi.org/10.1073/pnas.0601066103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16567619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16567619"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Keiko Takahashi, Naofumi Yoshida, Naoko Murakami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic regulation of p53 subnuclear localization and senescence by MORC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-08-0747"}], "href": "https://doi.org/10.1091/mbc.e06-08-0747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17332504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17332504"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yasuhiro Mimura, Keiko Takahashi, Kiyo Kawata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two-step colocalization of MORC3 with PML nuclear bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.063586"}], "href": "https://doi.org/10.1242/jcs.063586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20501696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20501696"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Forest H Andrews, Qiong Tong, Kelly D Sullivan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.08.050"}], "href": "https://doi.org/10.1016/j.celrep.2016.08.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27653685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27653685"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yi Zhang, Brianna J Klein, Khan L Cox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism for autoinhibition and activation of the MORC3 ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1819524116"}], "href": "https://doi.org/10.1073/pnas.1819524116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30850548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30850548"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yi Zhang, JaeWoo Ahn, Kelsie J Green, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MORC3 Is a Target of the Influenza A Viral Protein NS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2019.03.015"}], "href": "https://doi.org/10.1016/j.str.2019.03.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31006586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31006586"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sophia Groh, Anna Viktoria Milton, Lisa Katherina Marinelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26288-7"}], "href": "https://doi.org/10.1038/s41467-021-26288-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34650047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34650047"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lorena S Ver, Laura Marcos-Villar, Sara Landeras-Bueno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01530-15"}], "href": "https://doi.org/10.1128/JVI.01530-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26202233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26202233"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Elizabeth Sloan, Anne Orr, Roger D Everett "}, {"type": "b", "children": [{"type": "t", "text": "MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00621-16"}], "href": "https://doi.org/10.1128/JVI.00621-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27440897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27440897"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Moritz M Gaidt, Alyssa Morrow, Marian R Fairgrieve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Self-guarding of MORC3 enables virulence factor-triggered immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-021-04054-5"}], "href": "https://doi.org/10.1038/s41586-021-04054-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34759314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34759314"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lindsey E Fox, Deborah J Lenschow "}, {"type": "b", "children": [{"type": "t", "text": "En garde! The duel functions of MORC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2021.12.017"}], "href": "https://doi.org/10.1016/j.chom.2021.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35026136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35026136"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xue-Hui Ma, Yong-Xuan Yao, Xian-Zhang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.28025"}], "href": "https://doi.org/10.1002/jmv.28025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35879101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35879101"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anna Champion, Alexandra Rowland, Levia Yee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.29227"}], "href": "https://doi.org/10.1002/jmv.29227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38009611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38009611"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuki Ichimura, Takashi Matsushita, Yasuhito Hamaguchi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar3822"}], "href": "https://doi.org/10.1186/ar3822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22546500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22546500"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Morgane Gossez, Marianne Levesque, Chahéra Khouatra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interstitial lung disease in an adult patient with dermatomyositis and anti-NXP2 autoantibody."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Respir Rev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1183/16000617.00006714"}], "href": "https://doi.org/10.1183/16000617.00006714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26028648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26028648"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Anna Rogers, Lorinda Chung, Shufeng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Care Res (Hoboken) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acr.23210"}], "href": "https://doi.org/10.1002/acr.23210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28129490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28129490"}]}]}]}
Synonyms	ZCWCC3, ZCW5, NXP2
Proteins	MORC3_HUMAN
NCBI Gene ID	23515
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MORC3 has 5,985 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for MORC3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MORC3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MORC3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MORC3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MORC3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MORC3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MORC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MORC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MORC3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MORC3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MORC3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MORC3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MORC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MORC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MORC3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MORC3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MORC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MORC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MORC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MORC3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MORC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MORC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MORC3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MORC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MORC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MORC3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MORC3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MORC3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MORC3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MORC3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MORC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MORC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MORC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MORC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MORC3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MORC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MORC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MORC3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MORC3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MORC3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MORC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MORC3 from the GeneSigDB Published Gene Signatures dataset.