{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the literature provided reveals that none of the abstracts address or mention MORN3. In these studies, the focus is almost exclusively on members of the transient receptor potential (TRPC) channel family—particularly TRPC6—and their roles in diverse physiological and pathological processes such as the regulation of vascular smooth muscle tone, myofibroblast transformation, pulmonary vasoconstriction, cardiac hypertrophy, synaptic and behavioral plasticity, podocyte function in the kidney, and various processes in cell migration and inflammation. Consequently, no functional insights or experimental data regarding MORN3 can be extracted from the provided summaries. It remains unclear from this collection whether MORN3 plays a role in any of the cellular or tissue regulatory mechanisms described by these reports."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexander Dietrich, Michael Mederos Y Schnitzler, Maik Gollasch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased vascular smooth muscle contractility in TRPC6-/- mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.16.6980-6989.2005"}], "href": "https://doi.org/10.1128/MCB.25.16.6980-6989.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16055711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16055711"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer Davis, Adam R Burr, Gregory F Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2012.08.017"}], "href": "https://doi.org/10.1016/j.devcel.2012.08.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23022034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23022034"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Norbert Weissmann, Alexander Dietrich, Beate Fuchs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606728103"}], "href": "https://doi.org/10.1073/pnas.0606728103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17142322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17142322"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xu Wu, Petra Eder, Baojun Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPC channels are necessary mediators of pathologic cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1001825107"}], "href": "https://doi.org/10.1073/pnas.1001825107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20351294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20351294"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dequan Tian, Sarah M P Jacobo, David Billing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2001200"}], "href": "https://doi.org/10.1126/scisignal.2001200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20978238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20978238"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mohammad Tauseef, Nebojsa Knezevic, Koteswara R Chava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20111355"}], "href": "https://doi.org/10.1084/jem.20111355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23045603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23045603"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tom Nijenhuis, Alexis J Sloan, Joost G J Hoenderop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.06.033"}], "href": "https://doi.org/10.1016/j.ajpath.2011.06.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21839714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21839714"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian Zhou, Wanlu Du, Kechun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of TRPC6 channels in the formation of excitatory synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2127"}], "href": "https://doi.org/10.1038/nn.2127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18516035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18516035"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chihiro Hisatsune, Yukiko Kuroda, Kyoko Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of TRPC6 channel activity by tyrosine phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311274200"}], "href": "https://doi.org/10.1074/jbc.M311274200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14761972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14761972"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nicole Alessandri-Haber, Olayinka A Dina, Xiaoje Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0893-09.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.0893-09.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19439599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19439599"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Norbert Weissmann, Akylbek Sydykov, Hermann Kalwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1660"}], "href": "https://doi.org/10.1038/ncomms1660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22337127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22337127"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michael Foller, Ravi S Kasinathan, Saisudha Koka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPC6 contributes to the Ca(2+) leak of human erythrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000113760"}], "href": "https://doi.org/10.1159/000113760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18209485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18209485"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Volodymyr V Tsvilovskyy, Alexander V Zholos, Thomas Aberle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2009.06.046"}], "href": "https://doi.org/10.1053/j.gastro.2009.06.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549525"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Norimichi Koitabashi, Takeshi Aiba, Geoffrey G Hesketh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2009.11.015"}], "href": "https://doi.org/10.1016/j.yjmcc.2009.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19961855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19961855"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kathryn Quick, Jing Zhao, Niels Eijkelkamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1098/rsob.120068"}], "href": "https://doi.org/10.1098/rsob.120068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22724068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22724068"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hideyuki Kinoshita, Koichiro Kuwahara, Motohiro Nishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.109.208314"}], "href": "https://doi.org/10.1161/CIRCRESAHA.109.208314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20448219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20448219"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yong Zhang, Wei Qin, Longyin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep09401"}], "href": "https://doi.org/10.1038/srep09401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25801675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25801675"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Motohiro Nishida, Kenta Watanabe, Yoji Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.074104"}], "href": "https://doi.org/10.1074/jbc.M109.074104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20177073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20177073"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Paola Krall, Cesar P Canales, Pamela Kairath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012859"}], "href": "https://doi.org/10.1371/journal.pone.0012859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20877463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20877463"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Eun Young Kim, Marc Anderson, Stuart E Dryer "}, {"type": "b", "children": [{"type": "t", "text": "Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00423.2011"}], "href": "https://doi.org/10.1152/ajprenal.00423.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22031853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22031853"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hua Zhang, Suya Sun, Lili Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1188-16.2016"}], "href": "https://doi.org/10.1523/JNEUROSCI.1188-16.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27881772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27881772"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "V Dyachenko, B Husse, U Rueckschloss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Calcium (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ceca.2008.06.003"}], "href": "https://doi.org/10.1016/j.ceca.2008.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18635261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18635261"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Marc Anderson, Eun Young Kim, Henning Hagmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00095.2013"}], "href": "https://doi.org/10.1152/ajpcell.00095.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23657570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23657570"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Evan W Weber, Fei Han, Mohammad Tauseef, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20150353"}], "href": "https://doi.org/10.1084/jem.20150353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26392222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26392222"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Rebecca Elsaesser, Giorgia Montani, Roberto Tirindelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidyl-inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2005.04108.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2005.04108.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15926917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15926917"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yueh-Lin Wu, Jian Xie, Sung-Wan An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.kint.2016.09.039"}], "href": "https://doi.org/10.1016/j.kint.2016.09.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27979597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27979597"}]}]}]}