{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough you requested a summary of the function of MPPE1, none of the provided abstracts mention MPPE1. Instead, these studies consistently focus on the X‐linked inhibitor of apoptosis protein (XIAP), which has emerged as a pivotal regulator of cell fate. XIAP is best known for its anti‐apoptotic activity, functioning mainly by directly binding to and inhibiting effector caspases and by serving as an E3 ubiquitin ligase. In doing so, XIAP modulates cell death pathways in diverse cell types—from lymphocytes and hepatocytes to neurons and cancer cells—thereby influencing processes such as FAS‐induced apoptosis, mitochondrial cytochrome c release, and death receptor signaling. This body of work shows that, although our query was about MPPE1, the collective insights instead outline how XIAP discriminates between cell survival and death signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther analysis of the abstracts reveals that beyond caspase inhibition, XIAP is crucial for the regulation of inflammatory and innate immune responses. In several studies, XIAP is shown to interact with key signaling molecules—such as RIP kinases, NOD2, and components of the TNF receptor complex—to modulate NF‐κB activation and cytokine production. These interactions contribute not only to the fine‐tuning of the cellular response to microbial invasion (via NOD and Toll‐like receptors) but also to the regulation of responses in immune cells such as dendritic cells and neutrophils. By controlling the balance between pro‐apoptotic and pro‐inflammatory signals, XIAP thereby also impacts the progression of infectious and inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional publications demonstrate the clinical and physiological significance of XIAP activity. In several animal models, XIAP deficiency or targeted inhibition has been linked with exacerbated tissue injury in conditions such as stroke, neurodegeneration, and acute pancreatitis, whereas its overexpression confers resistance to apoptosis in neurons and other terminally differentiated cells. Moreover, XIAP’s ability to engage with other signaling cascades—whether by modulating mitochondrial dynamics, affecting ubiquitination of substrates, or even interacting with cell cycle regulators during mitosis—underscores its multifaceted roles in maintaining cellular homeostasis. Collectively, these findings point to XIAP as a central node in the control of apoptosis and inflammation, with potential implications for therapeutic strategies in cancer, immune disorders, and neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "42"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mamoru Shibata, Hidenori Hattori, Takahiro Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00001756-200210280-00031"}], "href": "https://doi.org/10.1097/00001756-200210280-00031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12395105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12395105"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S J Crocker, P Liston, H Anisman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0969-9961(02)00020-7"}], "href": "https://doi.org/10.1016/s0969-9961(02"}, {"type": "t", "text": "00020-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12667469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12667469"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thorsten Trapp, Laura Korhonen, Michael Besselmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1044-7431(03)00013-7"}], "href": "https://doi.org/10.1016/s1044-7431(03"}, {"type": "t", "text": "00013-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12812761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12812761"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Atsushi Saito, Takeshi Hayashi, Shuzo Okuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cereb Blood Flow Metab (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.WCB.0000080702.47016.FF"}], "href": "https://doi.org/10.1097/01.WCB.0000080702.47016.FF"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12973017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12973017"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Patrick Ryan Potts, Shweta Singh, Malia Knezek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200307130"}], "href": "https://doi.org/10.1083/jcb.200307130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14623868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14623868"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carolyn Cao, Yi Mu, Dennis E Hallahan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207929"}], "href": "https://doi.org/10.1038/sj.onc.1207929"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15258565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15258565"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Juliet Emamaullee, Peter Liston, Robert G Korneluk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transplant (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-6143.2005.00891.x"}], "href": "https://doi.org/10.1111/j.1600-6143.2005.00891.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15888033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15888033"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zaiping Liu, Hongbing Li, Mathieu Derouet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M503724200"}], "href": "https://doi.org/10.1074/jbc.M503724200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16115895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16115895"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Swayamjot Kaur, Fang Wang, Manickam Venkatraman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505671200"}], "href": "https://doi.org/10.1074/jbc.M505671200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16157589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16157589"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hanna Wootz, Inga Hansson, Laura Korhonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2006.02.021"}], "href": "https://doi.org/10.1016/j.yexcr.2006.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16566922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16566922"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Michael Y Fessing, Tatyana Y Sharova, Andrey A Sharov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the Edar signaling in the control of hair follicle involution (catagen)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2006.060227"}], "href": "https://doi.org/10.2353/ajpath.2006.060227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17148670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17148670"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wen-Hsien Liu, Huey-Wen Hsiao, Wen-I Tsou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601611"}], "href": "https://doi.org/10.1038/sj.emboj.7601611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17318174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17318174"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Craig S Moore, Andrea L O Hebb, Mathieu M Blanchard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2008.06.030"}], "href": "https://doi.org/10.1016/j.jneuroim.2008.06.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18687476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18687476"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ulrike Resch, Yvonne M Schichl, Susanne Sattler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP regulates intracellular ROS by enhancing antioxidant gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.07.142"}], "href": "https://doi.org/10.1016/j.bbrc.2008.07.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18692482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18692482"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jian Wang, Trevor Menchenton, Shankai Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2008.07.016"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2008.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18755525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18755525"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gabriele Winsauer, Ulrike Resch, Renate Hofer-Warbinek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2008.08.004"}], "href": "https://doi.org/10.1016/j.cellsig.2008.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18761086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18761086"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anthony H K Tsang, Yun-Il Lee, Han Seok Ko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0810595106"}], "href": "https://doi.org/10.1073/pnas.0810595106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19273858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19273858"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Michelle I Smith, Yolanda Y Huang, Mohanish Deshmukh "}, {"type": "b", "children": [{"type": "t", "text": "Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005097"}], "href": "https://doi.org/10.1371/journal.pone.0005097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19333375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19333375"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Céline Van Themsche, Valérie Leblanc, Sophie Parent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C109.009522"}], "href": "https://doi.org/10.1074/jbc.C109.009522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19473982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19473982"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jason R Neil, Maozhen Tian, William P Schiemann "}, {"type": "b", "children": [{"type": "t", "text": "X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.018374"}], "href": "https://doi.org/10.1074/jbc.M109.018374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19531477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19531477"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Tim West, Madeliene Stump, Gregory Lodygensky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ASN Neuro (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/AN20090005"}], "href": "https://doi.org/10.1042/AN20090005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570023"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Philipp J Jost, Stephanie Grabow, Daniel Gray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP discriminates between type I and type II FAS-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08229"}], "href": "https://doi.org/10.1038/nature08229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19626005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19626005"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Minna Kairisalo, Laura Korhonen, Mari Sepp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2009.06898.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2009.06898.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19735291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19735291"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Zhipei Liu, Jia Shen, Kui Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2009.09.012"}], "href": "https://doi.org/10.1016/j.bbamcr.2009.09.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19782107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19782107"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Morihisa Fujita, Yusuke Maeda, Moonjin Ra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.08.040"}], "href": "https://doi.org/10.1016/j.cell.2009.08.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19837036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19837036"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Bing Z Carter, Duncan H Mak, Wendy D Schober, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-03-212563"}], "href": "https://doi.org/10.1182/blood-2009-03-212563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19897582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19897582"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hridayesh Prakash, Marco Albrecht, Daniel Becker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.096297"}], "href": "https://doi.org/10.1074/jbc.M109.096297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20427267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20427267"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Bavat Bornstein, Yossi Gottfried, Natalia Edison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Apoptosis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10495-011-0622-0"}], "href": "https://doi.org/10.1007/s10495-011-0622-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21695558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21695558"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Chad Siegel, Jun Li, Fudong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1102635108"}], "href": "https://doi.org/10.1073/pnas.1102635108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21709246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21709246"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Raghu Gogada, Varun Prabhu, Michael Amadori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.202440"}], "href": "https://doi.org/10.1074/jbc.M110.202440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21712378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21712378"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.04.014"}], "href": "https://doi.org/10.1016/j.molcel.2012.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22607974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22607974"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Nicolas Unsain, Julia M Higgins, Kristen N Parker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP regulates caspase activity in degenerating axons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2013.07.015"}], "href": "https://doi.org/10.1016/j.celrep.2013.07.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23954782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23954782"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Amy V Paschall, Mary A Zimmerman, Christina M Torres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-14-24"}], "href": "https://doi.org/10.1186/1471-2407-14-24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24422988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24422988"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Monica Yabal, Nicole Müller, Heiko Adler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.05.008"}], "href": "https://doi.org/10.1016/j.celrep.2014.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24882010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24882010"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Kazushi Aoto, Paul A Trainor "}, {"type": "b", "children": [{"type": "t", "text": "Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu489"}], "href": "https://doi.org/10.1093/hmg/ddu489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25292199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25292199"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Simone Wicki, Ursina Gurzeler, W Wei-Lynn Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.311"}], "href": "https://doi.org/10.1038/cddis.2016.311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27735938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27735938"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yong Liu, Xiao-Dong Chen, Jiang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.70"}], "href": "https://doi.org/10.1038/cddis.2017.70"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28300832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28300832"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Kate E Lawlor, Rebecca Feltham, Monica Yabal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.06.073"}], "href": "https://doi.org/10.1016/j.celrep.2017.06.073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28723569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28723569"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Yonghui Yu, Honglei Jin, Jiheng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31223"}], "href": "https://doi.org/10.1002/ijc.31223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29250796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29250796"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Sylwia Gradzka, Oliver S Thomas, Oliver Kretz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0508-y"}], "href": "https://doi.org/10.1038/s41419-018-0508-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29743550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29743550"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Dikchha Rijal, Ardeshir Ariana, Andrew Wight, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.003614"}], "href": "https://doi.org/10.1074/jbc.RA118.003614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29899110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29899110"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Yun Liao, Junjie Zhao, Katarzyna Bulek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14698-y"}], "href": "https://doi.org/10.1038/s41467-020-14698-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32060280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32060280"}]}]}]}