MPV17 Gene

Name	MpV17 mitochondrial inner membrane protein
Description	This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMPV17 is an integral mitochondrial inner membrane protein that plays a critical role in maintaining mitochondrial DNA (mtDNA) integrity and proper oxidative phosphorylation. Loss‐of‐function mutations in MPV17 lead to severe, tissue‐specific mtDNA depletion with consequent energy failure—manifesting most prominently in hepatocerebral forms of mitochondrial DNA depletion syndrome (MDDS), including Navajo neurohepatopathy, and sometimes extending to isolated liver failure, sensorimotor neuropathy, or multisystem involvement. A wide variety of mutation types (missense, frameshift, splice‐site, and intronic) have been reported that not only elucidate genotype–phenotype correlations but also emphasize the importance of MPV17 in sustaining mitochondrial nucleotide pools and redox balance. Comparative studies have also distinguished MPV17 from its homologs, reinforcing its unique mitochondrial localization and functional relevance in the pathology of MDDS."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies further reveal that MPV17 is capable of forming a non‐selective channel in the inner mitochondrial membrane—a pore with an estimated diameter of approximately 1.8 nm that exhibits voltage, pH, and redox sensitivity. Structural investigations using high‐resolution methods have shown that MPV17 adopts a compact fold with six membrane‐embedded α‐helices and assembles into oligomers, with disease‐linked mutations impairing this oligomerization. Moreover, recent evidence suggests that MPV17 may facilitate the maintenance of mitochondrial deoxythymidine monophosphate (dTMP) pools by potentially mediating the transport of cytosolic dTMP into mitochondria and sustaining folate‐mediated one‐carbon metabolism essential for mtDNA synthesis. Notably, while these channel and transport functions appear critical in the context of MDDS, experimental silencing of MPV17 in cancer cell models did not recapitulate mtDNA depletion or affect cell proliferation, highlighting a context‐dependent role for MPV17."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonella Spinazzola, Carlo Viscomi, Erika Fernandez-Vizarra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1765"}], "href": "https://doi.org/10.1038/ng1765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16582910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16582910"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Reiko Iida, Toshihiro Yasuda, Etsuko Tsubota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.04.008"}], "href": "https://doi.org/10.1016/j.bbrc.2006.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16631601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16631601"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Charalampos L Karadimas, Tuan H Vu, Stephen A Holve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Navajo neurohepatopathy is caused by a mutation in the MPV17 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/506913"}], "href": "https://doi.org/10.1086/506913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16909392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16909392"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lee-Jun C Wong, Nicola Brunetti-Pierri, Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.21799"}], "href": "https://doi.org/10.1002/hep.21799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17694548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17694548"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Antonella Spinazzola, Valeria Massa, Michio Hirano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of founder effect for an identical mtDNA depletion syndrome (MDS)-associated MPV17 mutation shared by Navajos and Italians."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2007.12.007"}], "href": "https://doi.org/10.1016/j.nmd.2007.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18261905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18261905"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aleix Navarro-Sastre, Elena Martín-Hernández, Yolanda Campos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lethal hepatopathy and leukodystrophy caused by a novel mutation in MPV17 gene: description of an alternative MPV17 spliced form."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2008.01.012"}], "href": "https://doi.org/10.1016/j.ymgme.2008.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18329934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18329934"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Antonella Spinazzola, René Santer, Orhan H Akman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatocerebral form of mitochondrial DNA depletion syndrome: novel MPV17 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Neurol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archneur.65.8.1108"}], "href": "https://doi.org/10.1001/archneur.65.8.1108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18695062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18695062"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rossella Parini, Francesca Furlan, Luigi Notarangelo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose metabolism and diet-based prevention of liver dysfunction in MPV17 mutant patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2008.08.019"}], "href": "https://doi.org/10.1016/j.jhep.2008.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19012992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19012992"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shunsaku Kaji, Kei Murayama, Ikuo Nagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fluctuating liver functions in siblings with MPV17 mutations and possible improvement associated with dietary and pharmaceutical treatments targeting respiratory chain complex II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2009.04.014"}], "href": "https://doi.org/10.1016/j.ymgme.2009.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19520594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19520594"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ayman W El-Hattab, Fang-Yuan Li, Eric Schmitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2009.10.003"}], "href": "https://doi.org/10.1016/j.ymgme.2009.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20074988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20074988"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Johanna Uusimaa, Julie Evans, Conrad Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical, biochemical, cellular and molecular characterization of mitochondrial DNA depletion syndrome due to novel mutations in the MPV17 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2013.112"}], "href": "https://doi.org/10.1038/ejhg.2013.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23714749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23714749"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "D Piekutowska-Abramczuk, M Pronicki, K Strawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel c.191C>G (p.Pro64Arg) MPV17 mutation identified in two pairs of unrelated Polish siblings with mitochondrial hepatoencephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12228"}], "href": "https://doi.org/10.1111/cge.12228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23829229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23829229"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yu-Ri Choi, Young Bin Hong, Sung-Chul Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel homozygous MPV17 mutation in two families with axonal sensorimotor polyneuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-015-0430-1"}], "href": "https://doi.org/10.1186/s12883-015-0430-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26437932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26437932"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "C P Bitting, J A Hanson "}, {"type": "b", "children": [{"type": "t", "text": "Navajo Neurohepatopathy : A Case Report and Literature Review Emphasizing Clinicopathologic Diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Gastroenterol Belg (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28209105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28209105"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "S Meldau, R J De Lacy, G T M Riordan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a single MPV17 nonsense-associated altered splice variant in 24 South African infants with mitochondrial neurohepatopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13208"}], "href": "https://doi.org/10.1111/cge.13208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29318572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29318572"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Matthias Baumann, Herbert Schreiber, Beate Schlotter-Weigel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPV17 mutations in juvenile- and adult-onset axonal sensorimotor polyneuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13462"}], "href": "https://doi.org/10.1111/cge.13462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30298599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30298599"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ganye Zhao, Xiaoyan Zhao, Xuechao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Genetic testing and prenatal diagnosis for a Chinese pedigree affected with mitochondrial DNA depletion syndrome due to variant of MPV17 gene]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn511374-20210718-00604"}], "href": "https://doi.org/10.3760/cma.j.cn511374-20210718-00604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36184088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36184088"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Arghya Samanta, Anshu Srivastava, Kausik Mandal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPV17 mutation-related mitochondrial DNA depletion syndrome: A case series in infants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Indian J Gastroenterol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12664-022-01281-0"}], "href": "https://doi.org/10.1007/s12664-022-01281-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36753038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36753038"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Vasily D Antonenkov, Antti Isomursu, Daniela Mennerich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.608083"}], "href": "https://doi.org/10.1074/jbc.M114.608083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25861990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25861990"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Judith R Alonzo, Chantel Venkataraman, Martha S Field, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.004788"}], "href": "https://doi.org/10.1074/jbc.RA118.004788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30385507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30385507"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Morgane Canonne, Anaïs Wanet, Thuy Truong An Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPV17 does not control cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0229834"}], "href": "https://doi.org/10.1371/journal.pone.0229834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32155188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32155188"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Laura E Sperl, Franz Hagn "}, {"type": "b", "children": [{"type": "t", "text": "NMR Structural and Biophysical Analysis of the Disease-Linked Inner Mitochondrial Membrane Protein MPV17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2021.167098"}], "href": "https://doi.org/10.1016/j.jmb.2021.167098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34116124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34116124"}]}]}]}
Synonyms	MTDPS6, SYM1
Proteins	MPV17_HUMAN
NCBI Gene ID	4358
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MPV17 has 6,420 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for MPV17 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MPV17 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MPV17 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MPV17 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MPV17 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MPV17 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MPV17 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MPV17 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MPV17 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MPV17 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MPV17 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MPV17 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MPV17 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MPV17 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MPV17 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MPV17 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MPV17 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MPV17 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MPV17 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MPV17 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MPV17 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MPV17 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MPV17 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MPV17 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MPV17 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MPV17 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MPV17 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MPV17 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MPV17 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MPV17 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MPV17 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MPV17 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MPV17 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MPV17 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MPV17 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MPV17 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MPV17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MPV17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MPV17 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MPV17 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MPV17 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MPV17 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.