Name | melanocortin 2 receptor accessory protein 2 |
Description | This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMRAP2 is an accessory protein that modulates the trafficking and signaling of several G protein–coupled receptors—most notably members of the melanocortin receptor (MCR) family. In vitro studies have demonstrated that MRAP2 interacts with all five MCRs, promoting functional expression of the ACTH receptor (MC2R) while concurrently dampening the ligand responsiveness of MC1R, MC3R, MC4R, and MC5R. In polarized cells, for instance, proper delivery of MC3R to the apical membrane has been shown to involve MRAP2, highlighting its important role in receptor localization and function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its mechanistic role at the cellular level, MRAP2 is emerging as a key regulator of energy homeostasis and body weight. Mouse models harboring whole‐body or brain‐specific deletions of Mrap2 develop severe obesity early in life, implicating impaired receptor modulation—particularly at the melanocortin‐4 receptor (MC4R)—as one underlying mechanism. In humans, rare genetic variants and copy number changes affecting MRAP2 have been linked to early‐onset obesity, hyperphagia, and metabolic disturbances such as hyperglycemia and hypertension, emphasizing the protein’s significance in metabolic regulation and its contribution to monogenic forms of obesity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to modulating melanocortin receptors, MRAP2 regulates other G protein–coupled receptors that are central to feeding behavior and energy expenditure. It has been shown to inhibit the trafficking and signaling of prokineticin receptor 1 (PKR1) and the orexin receptor 1 (OX1R), both of which are expressed in the brain regions governing appetite. Moreover, MRAP2 biases the signaling of the ghrelin receptor (GHSR1a) by suppressing its constitutive activity, enhancing G protein–dependent signaling, and limiting β‐arrestin recruitment. Intriguingly, altered MRAP2 expression has now also been observed in the endometrium—suggesting potential roles in reproductive physiology and even embryo implantation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, MRAP2 is distinguished by its unusual dual membrane topology. It assembles as an anti‐parallel homodimer and is capable of forming higher–order oligomers through interactions mediated by its transmembrane domain. These unique structural features underpin its capacity to differentially modulate receptor signaling across diverse physiological systems, thereby providing insights into its versatile roles in metabolic and potentially reproductive processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li F Chan, Tom R Webb, Teng-Teng Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0809918106"}], "href": "https://doi.org/10.1073/pnas.0809918106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19329486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19329486"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julien A Sebag, Patricia M Hinkle "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000593"}], "href": "https://doi.org/10.1126/scisignal.2000593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20371771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20371771"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rebecca J Gorrigan, Leonardo Guasti, Peter King, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-11-0011"}], "href": "https://doi.org/10.1530/JME-11-0011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21367968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21367968"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Johannes Hofland, Patric J Delhanty, Jacobie Steenbergen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-2328"}], "href": "https://doi.org/10.1210/jc.2011-2328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22419722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22419722"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "T V Novoselova, D Jackson, D C Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melanocortin receptor accessory proteins in adrenal gland physiology and beyond."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-12-0501"}], "href": "https://doi.org/10.1530/JOE-12-0501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23418361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23418361"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jeenah Park, Neeraj Sharma, Garry R Cutting "}, {"type": "b", "children": [{"type": "t", "text": "Melanocortin 3 receptor has a 5' exon that directs translation of apically localized protein from the second in-frame ATG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2014-1105"}], "href": "https://doi.org/10.1210/me.2014-1105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25051171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25051171"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Masato Asai, Shwetha Ramachandrappa, Maria Joachim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1233000"}], "href": "https://doi.org/10.1126/science.1233000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23869016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23869016"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Emma I Kay, Rikus Botha, Johanna M Montgomery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0140320"}], "href": "https://doi.org/10.1371/journal.pone.0140320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26469516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26469516"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ellen Geets, Doreen Zegers, Sigri Beckers, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2017.05.008"}], "href": "https://doi.org/10.1016/j.bbadis.2017.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28499989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28499989"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Morgane Baron, Julie Maillet, Marlène Huyvaert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-019-0622-0"}], "href": "https://doi.org/10.1038/s41591-019-0622-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31700171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31700171"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ana Carolina Proença da Fonseca, Gabriella Medeiros Abreu, Verônica Marques Zembrzuski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eat Weight Disord (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40519-020-00946-z"}], "href": "https://doi.org/10.1007/s40519-020-00946-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32578125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32578125"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Alix A J Rouault, Abigail A Lee, Julien A Sebag "}, {"type": "b", "children": [{"type": "t", "text": "Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2017.09.008"}], "href": "https://doi.org/10.1016/j.bbamcr.2017.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28939058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28939058"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Marco D'Aurora, Federica Romani, Sara Franchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRAP2 regulates endometrial receptivity and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.04.001"}], "href": "https://doi.org/10.1016/j.gene.2019.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30951854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30951854"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alix A J Rouault, Luciana K Rosselli-Murai, Ciria C Hernandez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aax4569"}], "href": "https://doi.org/10.1126/scisignal.aax4569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31911434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31911434"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Valerie Chen, Antonio E Bruno, Laura L Britt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015482"}], "href": "https://doi.org/10.1074/jbc.RA120.015482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32943551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32943551"}]}]}]}
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Synonyms | BA51G5.2, BMIQ18, C6ORF117 |
Proteins | MRAP2_HUMAN |
NCBI Gene ID | 112609 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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MRAP2 has 3,318 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 89 datasets.
Click the + buttons to view associations for MRAP2 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MRAP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MRAP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MRAP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MRAP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MRAP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MRAP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with MRAP2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MRAP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of MRAP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MRAP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MRAP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MRAP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MRAP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with MRAP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with MRAP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with MRAP2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with MRAP2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by MRAP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving MRAP2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving MRAP2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MRAP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MRAP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with MRAP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with MRAP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MRAP2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MRAP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of MRAP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MRAP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with MRAP2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with MRAP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MRAP2 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MRAP2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MRAP2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MRAP2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MRAP2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MRAP2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving MRAP2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving MRAP2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving MRAP2 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing MRAP2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by MRAP2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by MRAP2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by MRAP2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of MRAP2 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MRAP2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MRAP2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GWASdb SNP-Disease Associations | diseases associated with MRAP2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with MRAP2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of MRAP2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of MRAP2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of MRAP2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by MRAP2 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for MRAP2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MRAP2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MRAP2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with MRAP2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MRAP2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MRAP2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MRAP2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting MRAP2 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MRAP2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by MRAP2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with MRAP2 gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for MRAP2 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MRAP2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MRAP2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving MRAP2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving MRAP2 protein from the Wikipathways PFOCR 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MRAP2 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MRAP2 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MRAP2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MRAP2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MRAP2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MRAP2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of MRAP2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of MRAP2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MRAP2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MRAP2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MRAP2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MRAP2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MRAP2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MRAP2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MRAP2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MRAP2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |