MRGBP Gene

Name	MRG/MORF4L binding protein
Description	Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleoplasm. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMRGBP, also known as C20orf20, is a previously uncharacterized protein that functions as a defined subunit of the TRRAP/TIP60 histone acetyltransferase complex. Its association with other chromatin regulators—including MRG15, MRGX, TRCp120, and DMAP1—suggests that MRGBP helps to organize multi‐protein assemblies that catalyze histone acetylation and thereby modulate chromatin structure and transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMRGBP expression is frequently found to be upregulated in several malignancies. In colorectal tumors, as well as in cutaneous squamous cell and hepatocellular carcinomas, increased gene copy number and elevated transcript levels have been linked with enhanced cell proliferation, cell cycle progression, and malignant transformation. Functional studies indicate that MRGBP promotes tumor growth and progression by upregulating a network of genes involved in DNA replication and cell division. In colorectal cancer, for example, MRGBP not only facilitates proliferation but also contributes to epithelial–mesenchymal transition through suppression of antagonistic molecules such as DKK1 and activation of the Wnt/β-catenin and NF-κB/p65 pathways. These findings underscore its potential as both a prognostic biomarker and a therapeutic target in cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in transcriptional regulation and oncogenesis, MRGBP appears to have an unexpected function in the maintenance of genome integrity. Studies have demonstrated that downregulation of MRGBP enhances DNA double-strand break repair, particularly by stimulating early events of homologous recombination. This suggests that under normal conditions MRGBP may act as a general inhibitor of DNA repair by limiting the activity of the NuA4 complex, thereby narrowing the extent of DNA-end resection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Cai, Jingji Jin, Chieri Tomomori-Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C300389200"}], "href": "https://doi.org/10.1074/jbc.C300389200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12963728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12963728"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "K Yamaguchi, M Sakai, T Shimokawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6605500"}], "href": "https://doi.org/10.1038/sj.bjc.6605500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20051959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20051959"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kiyoshi Yamaguchi, Michihiro Sakai, JooHun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRG-binding protein contributes to colorectal cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2011.01971.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2011.01971.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21535316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21535316"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S A Watt, C Pourreyron, K Purdie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.180"}], "href": "https://doi.org/10.1038/onc.2011.180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21602893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21602893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Juanjun Huang, Xiaoli Chen, Wei Zhu "}, {"type": "b", "children": [{"type": "t", "text": "MRGBP is a potential novel prognostic biomarker and is correlated with immune infiltrates in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000025234"}], "href": "https://doi.org/10.1097/MD.0000000000025234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33761715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33761715"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoli Long, Yukun Hu, Shiyu Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRGBP promotes colorectal cancer metastasis via DKK1/Wnt/β-catenin and NF-kB/p65 pathways mediated EMT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2022.113375"}], "href": "https://doi.org/10.1016/j.yexcr.2022.113375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36208716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36208716"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sabrina Rivero, Guillermo Rodríguez-Real, Inés Marín, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13071"}], "href": "https://doi.org/10.1002/2211-5463.13071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33354938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33354938"}]}]}]}
Synonyms	C20ORF20, EAF7, URCC4, MRG15BP
Proteins	MRGBP_HUMAN
NCBI Gene ID	55257
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MRGBP has 5,844 functional associations with biological entities spanning 7 categories (molecular profile, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.

Click the + buttons to view associations for MRGBP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MRGBP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MRGBP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MRGBP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MRGBP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MRGBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MRGBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MRGBP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MRGBP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MRGBP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MRGBP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MRGBP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MRGBP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MRGBP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MRGBP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MRGBP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MRGBP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MRGBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MRGBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MRGBP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MRGBP protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MRGBP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MRGBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MRGBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MRGBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MRGBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MRGBP protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MRGBP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MRGBP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MRGBP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MRGBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MRGBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MRGBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MRGBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MRGBP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MRGBP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MRGBP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MRGBP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MRGBP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MRGBP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MRGBP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MRGBP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.