{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMRPL10 is a mitochondrial ribosomal protein that contributes to the assembly and function of the large subunit in mitochondrial protein synthesis via its capacity to bind ribosomal RNA. Notably, the only abstract in this collection that touches on mitochondrial ribosomal components is the study examining RNA binding proteins from the bovine 39S subunit, which identified several strongly RNA-binding proteins (including L7, L13, L14, L21, L26, and L44) critical for early ribosomal assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although MRPL10 was not specifically mentioned or characterized in that study, by implication it belongs to the family of mitochondrial ribosomal proteins that ensure proper mitochondrial translation and, consequently, cellular energy production.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn clear contrast, the remaining abstracts in this collection focus exclusively on the neuroendocrine precursor proSAAS. They delineate a multifaceted role for proSAAS‐derived peptides in the central regulation of food intake, synaptic modulation via inhibition of prohormone convertase 1/3, prevention of pathogenic protein aggregation (especially amyloid fibrillation implicated in Alzheimer’s disease), and the modulation of behavior and metabolic responses under various stress and pharmacological challenges."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "11"}]}, {"type": "t", "text": " These studies collectively underscore the role of proSAAS in neuropeptide processing, neural circuitry modulation, and neuroprotection, while none of them extend their findings to MRPL10.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while MRPL10 plays a critical role in mitochondrial protein synthesis through its function as a ribosomal component, none of the provided abstracts offer direct insights into its function. Instead, the bulk of these studies elucidate the diverse neuroendocrine and neuroprotective actions of proSAAS-derived peptides, leaving the specific role of MRPL10 outside the scope of this collection.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M A Piatyszek, N D Denslow, T W O'Brien "}, {"type": "b", "children": [{"type": "t", "text": "RNA binding proteins of the large subunit of bovine mitochondrial ribosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (1988)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/16.6.2565"}], "href": "https://doi.org/10.1093/nar/16.6.2565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "3129699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/3129699"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yun Feng, Sandra E Reznik, Lloyd D Fricker "}, {"type": "b", "children": [{"type": "t", "text": "ProSAAS and prohormone convertase 1 are broadly expressed during mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Gene Expr Patterns (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1567-133x(02)00002-9"}], "href": "https://doi.org/10.1016/s1567-133x(02"}, {"type": "t", "text": "00002-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15018810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15018810"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daniel J Morgan, Nino Mzhavia, Bonnie Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Embryonic gene expression and pro-protein processing of proSAAS during rodent development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03138.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03138.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15935061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15935061"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daniel J Morgan, Suwen Wei, Ivone Gomes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2010.06706.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2010.06706.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20367757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20367757"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jonathan H Wardman, Iryna Berezniuk, Shi Di, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0028152"}], "href": "https://doi.org/10.1371/journal.pone.0028152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22164236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22164236"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ting Liu, Yanxia Zhao, Na Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0046934"}], "href": "https://doi.org/10.1371/journal.pone.0046934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23056534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23056534"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Juan R Peinado, Furqan Sami, Nina Rajpurohit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2013.09.006"}], "href": "https://doi.org/10.1016/j.febslet.2013.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24042052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24042052"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Akina Hoshino, Michael Helwig, Sina Rezaei, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.14209"}], "href": "https://doi.org/10.1111/jnc.14209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28881029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28881029"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Manita Shakya, Taha Yildirim, Iris Lindberg "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression and retention of the secretory chaperone proSAAS following cell stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stress Chaperones (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12192-020-01128-7"}], "href": "https://doi.org/10.1007/s12192-020-01128-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32607937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32607937"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dipendra K Aryal, Ramona M Rodriguiz, Ngoc Lien Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gbb.12827"}], "href": "https://doi.org/10.1111/gbb.12827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35878875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35878875"}]}]}]}