MS4A4E Gene

Name	membrane-spanning 4-domains, subfamily A, member 4E
Description	Most MS4A genes, including MS4A4E, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]
Proteins	M4A4E_HUMAN
NCBI Gene ID	643680
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MS4A4E has 701 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 22 datasets.

Click the + buttons to view associations for MS4A4E from the datasets below.

If available, associations are ranked by standardized value

Harmonizome

MS4A4E Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference:

Funding

	Dataset	Summary
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MS4A4E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MS4A4E gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DISEASES Experimental Gene-Disease Assocation Evidence Scores	diseases associated with MS4A4E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Assocation Evidence Scores	diseases co-occuring with MS4A4E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	GAD Gene-Disease Associations	diseases associated with MS4A4E gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MS4A4E gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GO Cellular Component Annotations	cellular components containing MS4A4E protein from the curated GO Cellular Component Annotations dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of MS4A4E gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MS4A4E gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GWAS Catalog SNP-Phenotype Associations	phenotypes associated with MS4A4E gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
	GWASdb SNP-Disease Associations	diseases associated with MS4A4E gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with MS4A4E gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of MS4A4E gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of MS4A4E protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MS4A4E gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with MS4A4E gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for MS4A4E protein from the InterPro Predicted Protein Domain Annotations dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of MS4A4E gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain MS4A4E protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of MS4A4E gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	NURSA Protein Complexes	protein complexs containing MS4A4E protein recovered by IP-MS from the NURSA Protein Complexes dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with MS4A4E protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.