MSH3 Gene

Name	mutS homolog 3
Description	The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMSH3 is a critical component of the mismatch repair (MMR) machinery that partners with MSH2 to form the MutSβ complex. Unlike its counterpart MutSα (MSH2–MSH6), MutSβ preferentially recognizes insertion–deletion loops—particularly those arising from di‐ and tetranucleotide repeats—and mediates repair events that maintain genomic stability. Structural and biochemical studies show that MutSβ binds to aberrant DNA structures, bends DNA at the site of an insertion–deletion loop, and collaborates with other repair factors (for example, PCNA and MutLα) to signal repair. Importantly, MSH3 deficiency or mutation is associated with the emergence of an “elevated microsatellite alterations” (EMAST) phenotype and has been demonstrated to contribute to a recessive form of colorectal adenomatous polyposis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in DNA mismatch repair, MSH3 has emerged as a key factor in modulating trinucleotide repeat dynamics. Studies in disorders such as myotonic dystrophy type 1 and Huntington’s disease indicate that the abundance and intrinsic ATPase activity of MSH3 drive the expansion of threshold-length CTG/CAG repeats. Furthermore, MSH3 deficiency impairs the repair of DNA double-strand breaks—rendering cells more sensitive to platinum-based chemotherapeutics—and underscores its dual role in both protecting against and, under certain conditions, promoting repeat expansions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent findings also highlight that alteration of MSH3’s subcellular localization and genetic variation can modulate its function and impact cancer risk and progression. Inflammatory signals—such as IL-6—can trigger nuclear export of MSH3, thereby reducing its availability for mismatch repair and contributing to EMAST. In parallel, several common polymorphisms and germline alterations in MSH3 have been associated with an increased risk of cancers including colorectal, ovarian, and head and neck tumors, as well as with differences in patient outcomes. In addition, MSH3 has been shown to participate in the activation of ATR at sites of DNA damage by binding to unusual DNA structures, and its interaction with scaffold proteins like SLX4 further integrates it into diverse genome maintenance pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "20"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shikha Gupta, Martin Gellert, Wei Yang "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2175"}], "href": "https://doi.org/10.1038/nsmb.2175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22179786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22179786"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Barbara A L Owen, Walter H Lang, Cynthia T McMurray "}, {"type": "b", "children": [{"type": "t", "text": "The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1596"}], "href": "https://doi.org/10.1038/nsmb.1596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19377479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19377479"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ravi R Iyer, Anna Pluciennik, Jochen Genschel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.104125"}], "href": "https://doi.org/10.1074/jbc.M110.104125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20154325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20154325"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anne-Marie M Gannon, Aisling Frizzell, Evan Healy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks810"}], "href": "https://doi.org/10.1093/nar/gks810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22941650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22941650"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stephanie S Tseng-Rogenski, Heekyung Chung, Maike B Wilk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0050616"}], "href": "https://doi.org/10.1371/journal.pone.0050616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23226332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23226332"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ronja Adam, Isabel Spier, Bixiao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2016.06.015"}], "href": "https://doi.org/10.1016/j.ajhg.2016.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27476653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27476653"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fernando Morales, Melissa Vásquez, Carolina Santamaría, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism in the MSH3 mismatch repair gene is associated with the levels of somatic instability of the expanded CTG repeat in the blood DNA of myotonic dystrophy type 1 patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2016.01.001"}], "href": "https://doi.org/10.1016/j.dnarep.2016.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26994442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26994442"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yanhao Lai, Helen Budworth, Jill M Beaver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12465"}], "href": "https://doi.org/10.1038/ncomms12465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27546332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27546332"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Norma Keogh, Kara Y Chan, Guo-Min Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx650"}], "href": "https://doi.org/10.1093/nar/gkx650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28973443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28973443"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Marion J Pollheimer, Peter Kornprat, Richard A Lindtner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis is a new promising prognostic factor in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2010.04.018"}], "href": "https://doi.org/10.1016/j.humpath.2010.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20869096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20869096"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lei Tian, Caixia Hou, Keli Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C109.014977"}], "href": "https://doi.org/10.1074/jbc.C109.014977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19525234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19525234"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kamila Burdova, Boris Mihaljevic, Andreas Sturzenegger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.06.026"}], "href": "https://doi.org/10.1016/j.molcel.2015.06.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26212458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26212458"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Koji Munakata, Minoru Koi, Takahito Kitajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Gastroenterol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14309/ctg.0000000000000105"}], "href": "https://doi.org/10.14309/ctg.0000000000000105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31789935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31789935"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stephanie S Tseng-Rogenski, Koji Munakata, Daniel Y Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00029-20"}], "href": "https://doi.org/10.1128/MCB.00029-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32284349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32284349"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Honglin Song, Susan J Ramus, Lydia Quaye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants in mismatch repair genes and risk of invasive ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgl089"}], "href": "https://doi.org/10.1093/carcin/bgl089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16774946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16774946"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sonja I Berndt, Elizabeth A Platz, M Daniele Fallin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24120"}], "href": "https://doi.org/10.1002/ijc.24120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19115210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19115210"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jun-Yan Liu, Chen-Yue Qian, Yuan-Feng Gao, et al. 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Synonyms	DUP, FAP4
Proteins	MSH3_HUMAN
NCBI Gene ID	4437
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MSH3 has 8,006 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for MSH3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MSH3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MSH3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MSH3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MSH3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MSH3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MSH3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MSH3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MSH3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MSH3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MSH3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MSH3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MSH3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MSH3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MSH3 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MSH3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MSH3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MSH3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MSH3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MSH3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MSH3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MSH3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MSH3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MSH3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MSH3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MSH3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MSH3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MSH3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MSH3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MSH3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MSH3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MSH3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MSH3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MSH3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MSH3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MSH3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MSH3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MSH3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MSH3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MSH3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MSH3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MSH3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.