{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMT1JP is a long non‐coding RNA that has emerged as a key tumor suppressor across several cancer types. In gastric cancer, for example, MT1JP has been shown to exert its tumor‐suppressive effects by associating with the RNA-binding protein TIAR to enhance the translation of the master tumor suppressor p53, thereby modulating cell cycle progression, apoptosis, and proliferation. This posttranscriptional mechanism underscores its critical role in restraining cell transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nFurthermore, MT1JP has been investigated in other malignancies: in retinoblastoma, its interplay with β-catenin signaling is under evaluation, suggesting it may contribute to the regulation of pathways involved in ocular tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non-small cell lung cancer, MT1JP suppresses tumor growth by regulating the miRNA-423-3p/Bim axis, resulting in reduced proliferation, invasion, and enhanced cell apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, in osteosarcoma, MT1JP appears to inhibit cell migration and invasion by upregulating miR-646, which in turn downregulates FGF2, pointing to its potential as an early diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n\nIn triple-negative breast cancer, MT1JP modulates the miR-138/HIF-1α axis to inhibit cell proliferation and migration, reinforcing its role as a molecular brake on tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, although MT1JP has been reported to function as a tumor suppressor in various cancers, its specific effects in cholangiocarcinoma remain to be evaluated, highlighting the ongoing need to elucidate its role across different tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihui Liu, Haiyan Yue, Qinghua Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1α (HIF-1α)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2077906"}], "href": "https://doi.org/10.1080/21655979.2022.2077906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35703312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35703312"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei Zhao, Jing Zhao, Xiao Guo, et al. 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