MTMR2 Gene

HGNC Family	Phosphatases
Name	myotubularin related protein 2
Description	This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMTMR2 is a member of the myotubularin phosphatase family that catalyzes the dephosphorylation of specific phosphoinositides—primarily phosphatidylinositol 3‐phosphate and phosphatidylinositol 3,5‐bisphosphate—thereby regulating key aspects of membrane trafficking and endosomal dynamics. Structural studies of MTMR2 have revealed a unique protein tyrosine phosphatase domain together with a GRAM module that adopts a pleckstrin homology–like fold, which together dictate the enzyme’s substrate specificity through an electrostatic, hydrogen bonding and hydrophobic network. These mechanistic insights strongly support a role for MTMR2 in controlling the turnover of endosomal phosphoinositides and, consequently, the proper execution of vesicular transport processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in MTMR2 have been causally linked to peripheral neuropathies such as Charcot‐Marie–Tooth disease type 4B1, where loss of function leads to demyelination and the appearance of focally folded myelin sheaths. Genetic screening in diverse patient cohorts has identified both de novo and inherited missense and truncating mutations, underscoring the clinical heterogeneity of the disease. In Schwann cells, MTMR2 is critically involved in early myelination, and its disruption not only impairs cell proliferation and survival but also perturbs vesicular trafficking pathways essential for myelin maintenance. These observations have been reinforced through studies in patient-derived cells and animal models, which together highlight the central role of MTMR2 in maintaining peripheral nerve integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "15"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its intrinsic catalytic properties, MTMR2 function is finely regulated by protein–protein interactions and post‐translational modifications. For example, binding to catalytically inactive family members such as MTMR5 not only enhances MTMR2 phosphatase activity but also influences its subcellular localization. Furthermore, site‐specific phosphorylation by kinases—including ERK1/2 at critical serine residues—dynamically modulates MTMR2’s targeting to distinct endosomal compartments, thereby controlling localized phosphoinositide pools and downstream signaling events. Emerging evidence also implicates aberrant MTMR2 expression in various cancers, suggesting that alterations in its regulation may contribute to tumor progression and could present new opportunities for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "22"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jocelyn Laporte, Laurence Liaubet, François Blondeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional redundancy in the myotubularin family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.2002.6445"}], "href": "https://doi.org/10.1006/bbrc.2002.6445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11846405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11846405"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jocelyn Laporte, Florence Bedez, Alessandra Bolino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg273"}], "href": "https://doi.org/10.1093/hmg/ddg273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12925573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12925573"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael J Begley, Gregory S Taylor, Soo-A Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00486-6"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00486-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14690594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14690594"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael J Begley, Gregory S Taylor, Melissa A Brock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0510006103"}], "href": "https://doi.org/10.1073/pnas.0510006103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16410353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16410353"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Odile Lecompte, Olivier Poch, Jocelyn Laporte "}, {"type": "b", "children": [{"type": "t", "text": "PtdIns5P regulation through evolution: roles in membrane trafficking?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Biochem Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tibs.2008.07.002"}], "href": "https://doi.org/10.1016/j.tibs.2008.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18774718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18774718"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Cornelius F Boerkoel, Hiroshi Takashima, Carlos A Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.10089"}], "href": "https://doi.org/10.1002/ana.10089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11835375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11835375"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eva Nelis, Sevim Erdem, Ersin Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel homozygous missense mutation in the myotubularin-related protein 2 gene associated with recessive Charcot-Marie-Tooth disease with irregularly folded myelin sheaths."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0960-8966(02)00046-9"}], "href": "https://doi.org/10.1016/s0960-8966(02"}, {"type": "t", "text": "00046-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12398840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12398840"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fred L Robinson, Jack E Dixon "}, {"type": "b", "children": [{"type": "t", "text": "The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505159200"}], "href": "https://doi.org/10.1074/jbc.M505159200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15998640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15998640"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alexandre Chojnowski, Nicole Ravisé, Corinne Bachelin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the Charcot-Marie-Tooth associated MTMR2 gene decreases proliferation and enhances cell death in primary cultures of Schwann cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2006.12.018"}], "href": "https://doi.org/10.1016/j.nbd.2006.12.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17336078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17336078"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stefano C Previtali, Angelo Quattrini, Alessandra Bolino "}, {"type": "b", "children": [{"type": "t", "text": "Charcot-Marie-Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Expert Rev Mol Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/S1462399407000439"}], "href": "https://doi.org/10.1017/S1462399407000439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17880751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17880751"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anne-Sophie Nicot, Jocelyn Laporte "}, {"type": "b", "children": [{"type": "t", "text": "Endosomal phosphoinositides and human diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2008.00754.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2008.00754.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18429927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18429927"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sonia Nouioua, Tarik Hamadouche, Benoit Funalot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in the PRX and the MTMR2 genes are responsible for unusual Charcot-Marie-Tooth disease phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2011.04.013"}], "href": "https://doi.org/10.1016/j.nmd.2011.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21741241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21741241"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Elizabeth A Fogarty, Megan H Brewer, Jose F Rodriguez-Molina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw233"}], "href": "https://doi.org/10.1093/hmg/ddw233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27466180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27466180"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Alberto Andrea Zambon, Maria Grazia Natali Sora, Giovanna Cantarella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vocal cord paralysis in Charcot-Marie-Tooth type 4b1 disease associated with a novel mutation in the myotubularin-related protein 2 gene: A case report and review of the literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2017.01.006"}], "href": "https://doi.org/10.1016/j.nmd.2017.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28190646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28190646"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daniel Halperin, Aviad Sapir, Ohad Wormser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel MTMR2 mutation causing severe Charcot-Marie-Tooth type 4B1 disease: a case report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-020-00617-2"}], "href": "https://doi.org/10.1007/s10048-020-00617-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32488727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32488727"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Soo-A Kim, Panayiotis O Vacratsis, Ron Firestein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0431052100"}], "href": "https://doi.org/10.1073/pnas.0431052100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12668758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12668758"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Norah E Franklin, Gregory S Taylor, Panayiotis O Vacratsis "}, {"type": "b", "children": [{"type": "t", "text": "Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.209122"}], "href": "https://doi.org/10.1074/jbc.M110.209122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21372139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21372139"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Norah E Franklin, Christopher A Bonham, Besa Xhabija, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential phosphorylation of the phosphoinositide 3-phosphatase MTMR2 regulates its association with early endosomal subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.113928"}], "href": "https://doi.org/10.1242/jcs.113928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23378027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23378027"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Matthieu A Raess, Belinda S Cowling, Dimitri L Bertazzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the neuropathy-associated MTMR2 gene rescues MTM1-associated myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx258"}], "href": "https://doi.org/10.1093/hmg/ddx258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28934386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28934386"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Lei Jiang, Jun-Yan Liu, Yan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNγ/STAT1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1186-z"}], "href": "https://doi.org/10.1186/s13046-019-1186-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31113461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31113461"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J Wang, A-L He, W-G Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTMR2 promotes the progression of NK/T cell lymphoma by targeting JAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202008_22489"}], "href": "https://doi.org/10.26355/eurrev_202008_22489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32767332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32767332"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuanqian Yao, Jiawen Lai, Yuwen Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrative analysis reveals the prognostic value and potential functions of MTMR2 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-46089-w"}], "href": "https://doi.org/10.1038/s41598-023-46089-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37907649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37907649"}]}]}]}
Synonyms	CMT4B1, CMT4B
Proteins	MTMR2_HUMAN
NCBI Gene ID	8898
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MTMR2 has 6,754 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for MTMR2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MTMR2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MTMR2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MTMR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MTMR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MTMR2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTMR2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTMR2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTMR2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MTMR2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MTMR2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MTMR2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MTMR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MTMR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MTMR2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MTMR2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MTMR2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MTMR2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MTMR2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MTMR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MTMR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTMR2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MTMR2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MTMR2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MTMR2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MTMR2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MTMR2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MTMR2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MTMR2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MTMR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MTMR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MTMR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MTMR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MTMR2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MTMR2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MTMR2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MTMR2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MTMR2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MTMR2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.