MTMR6 Gene

HGNC Family	Phosphatases
Name	myotubularin related protein 6
Description	Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in cytoplasm and nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMTMR6 is a phosphoinositide 3‐phosphatase that dephosphorylates both phosphatidylinositol 3‐phosphate and phosphatidylinositol (3,5)‐bisphosphate. Biochemical studies have shown that its activity is not only dependent on these substrates but is also positively regulated by the allosteric activator phosphatidylinositol 5‐phosphate. Moreover, MTMR6 forms heteromeric complexes with catalytically inactive partners such as MTMR9, and this association markedly enhances its lipid binding capacity, increases its phosphatase activity, and stabilizes the protein within the cell."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its intrinsic phosphatase activity, MTMR6 plays pivotal roles in cellular signaling and trafficking. In T lymphocytes, it acts as a negative regulator of Ca²⁺ influx by inhibiting the Ca²⁺‐activated K⁺ channel KCa3.1, thereby modulating T‐cell activation and proliferation. It also contributes to the completion of macropinocytosis by facilitating the sequential breakdown of phosphoinositides following membrane ruffle formation. In addition, interaction with GDP‐bound Rab1B regulates the intracellular localization of MTMR6 to perinuclear regions involved in early secretory and autophagic pathways, affecting vesicular trafficking and the formation of tubular omegasomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathologically, deregulation of MTMR6 is linked to abnormal cell proliferation and survival. In ovarian cancer, for instance, MTMR6 is upregulated—its expression being negatively regulated by miR-506-3p—which results in enhanced cell survival and altered cell cycle progression. In parallel, during visceral leishmaniasis, infection with virulent Leishmania donovani triggers a TLR2-mediated increase in MTMR6 levels in host macrophages, correlating with elevated IL-10 production and an increased intracellular parasite burden."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Schaletzky, Stephen K Dove, Benjamin Short, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0960-9822(03)00132-5"}], "href": "https://doi.org/10.1016/s0960-9822(03"}, {"type": "t", "text": "00132-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12646134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12646134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Zou, Shao-Chun Chang, Jasna Marjanovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804292200"}], "href": "https://doi.org/10.1074/jbc.M804292200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19038970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19038970"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shekhar Srivastava, Kyung Ko, Papiya Choudhury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00352-06"}], "href": "https://doi.org/10.1128/MCB.00352-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16847315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16847315"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yasuhiro Mochizuki, Riuko Ohashi, Takeshi Kawamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.395087"}], "href": "https://doi.org/10.1074/jbc.M112.395087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23188820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23188820"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masashi Maekawa, Shimpei Terasaka, Yasuhiro Mochizuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1311029111"}], "href": "https://doi.org/10.1073/pnas.1311029111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24591580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24591580"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuan Wang, Xia Lei, Chengying Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-506-3p suppresses the proliferation of ovarian cancer cells by negatively regulating the expression of MTMR6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biosci (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894107"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shabina Parveen, Saikat Majumder, Neelam Bodhale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myotubularin-related protein 6 is an ion channel-associated pro-leishmanial phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2024.111644"}], "href": "https://doi.org/10.1016/j.intimp.2024.111644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38330797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38330797"}]}]}]}
Proteins	MTMR6_HUMAN
NCBI Gene ID	9107
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MTMR6 has 5,459 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for MTMR6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MTMR6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MTMR6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MTMR6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MTMR6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTMR6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MTMR6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTMR6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTMR6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MTMR6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTMR6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MTMR6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MTMR6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MTMR6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MTMR6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MTMR6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MTMR6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MTMR6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MTMR6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MTMR6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MTMR6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MTMR6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTMR6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MTMR6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MTMR6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MTMR6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MTMR6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MTMR6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MTMR6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MTMR6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MTMR6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MTMR6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MTMR6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MTMR6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MTMR6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MTMR6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MTMR6 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MTMR6 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MTMR6 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MTMR6 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.