MXI1 Gene

HGNC Family	Basic helix-loop-helix proteins (BHLH), MAX dimerization proteins (MXD)
Name	MAX interactor 1, dimerization protein
Description	Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMXI1 is a pivotal component of the Myc/Max/Mad network that normally acts to counterbalance c‐Myc–mediated transcription and cell proliferation. In several tumor types, including glioblastoma, melanoma, medulloblastoma, and clear cell renal cancer, MXI1 functions as a tumor suppressor by repressing Myc target genes. For example, activation of FOXO3a in colon cancer cells induces the specific MXI1-SRα isoform, which mediates a promoter switch from Myc to MXI1 on E-box–containing genes and contributes to growth inhibition. In addition, studies in glioma have shown that direct targeting of MXI1 by miRNAs (such as miR‑24‑3p, miR‑27a‑3p, and miR‑155) reduces its expression, thereby promoting cell proliferation, while genetic mutations and loss of heterozygosity in hematological malignancies and prostate or medulloblastoma contexts further underscore its tumor suppressor role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer, MXI1 regulation is further complicated by post-translational modifications that impair its suppressive function. Studies have shown that phosphorylation by S6K1 primes MXI1 for recognition by the ubiquitin ligase β-TrCP and, in another context, UBE2O promotes its ubiquitination and degradation. Both pathways lead to reduced MXI1 protein levels, which diminishes its ability to antagonize Myc and thereby contributes to tumor progression and radioresistance in lung cancer. Additionally, a regulatory loop involving miRNA networks further modulates MXI1 expression in this setting."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMXI1 also exists as multiple isoforms arising from alternative promoter usage and splicing, which endow the protein with diverse and sometimes even opposing functions. The canonical isoforms, such as Mxi1-SRα and Mxi1-SRβ, robustly recruit corepressors like Sin3 and efficiently block Myc-driven transcription. In contrast, the MXI1-0 variant, whose expression can be induced by MYCN overexpression or hypoxic conditions, is less capable of opposing c-Myc and instead may promote proliferation, regulate angiogenic signaling (through modulation of VEGF expression), or even facilitate apoptosis in endothelial cells. These isoform-specific differences have been observed in various tumor models—including neuroblastoma, breast cancer, and in vascular endothelial cells—and highlight the multifaceted role of MXI1 in fine-tuning the Myc transcription factor network."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "I Manni, P Tunici, N Cirenei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6600065"}], "href": "https://doi.org/10.1038/sj.bjc.6600065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11875718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11875718"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shashi M Ariyanayagam-Baksh, Fabien K Baksh, Patricia A Swalsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.MP.0000087421.44975.1C"}], "href": "https://doi.org/10.1097/01.MP.0000087421.44975.1C"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14559981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14559981"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Deborah K Scott, Debbie Straughton, Michael Cole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.5.20.3360"}], "href": "https://doi.org/10.4161/cc.5.20.3360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17102621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17102621"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Oona Delpuech, Beatrice Griffiths, Philip East, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01789-06"}], "href": "https://doi.org/10.1128/MCB.01789-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17452451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17452451"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiao-Ling Guo, Ling Pan, Xue-Jun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10428190701342018"}], "href": "https://doi.org/10.1080/10428190701342018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17577784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17577784"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao-Hui Suo, Ling Pan, Li Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression and mutation of myc antagonist genes Mad1, Mxi1 and Rox in leukemia cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Xue Ye Xue Za Zhi (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18457265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18457265"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chun Chui Tsao, Bin T Teh, Eric Jonasch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Mxi1 suppresses HIF-2alpha-dependent renal cancer tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.7.10.6583"}], "href": "https://doi.org/10.4161/cbt.7.10.6583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19018165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19018165"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Weiyi Xu, Mingfa Liu, Xueling Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2012.1742"}], "href": "https://doi.org/10.3892/ijo.2012.1742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23254855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23254855"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jianwen Zhou, Wei Wang, Zhenhua Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0083055"}], "href": "https://doi.org/10.1371/journal.pone.0083055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24376632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24376632"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yumei Huang, Kaishun Hu, Sheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.22552"}], "href": "https://doi.org/10.7150/thno.22552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29507620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29507620"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yumei Huang, Xijie Yang, Yanwei Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-020-00616-8"}], "href": "https://doi.org/10.1038/s41418-020-00616-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32901121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32901121"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yujie Lei, Yunchao Huang, Jianbin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04778-w"}], "href": "https://doi.org/10.1038/s41419-022-04778-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35501353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35501353"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Claire Dugast-Darzacq, Melinda Pirity, Jennifer K Blanck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208107"}], "href": "https://doi.org/10.1038/sj.onc.1208107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15467743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15467743"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Norihiko Kawamata, Kei-Ji Sugimoto, Sakura Sakajiri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15809730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15809730"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Claire Dugast-Darzacq, Thierry Grange, Nicole B Schreiber-Agus "}, {"type": "b", "children": [{"type": "t", "text": "Differential effects of Mxi1-SRalpha and Mxi1-SRbeta in Myc antagonism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2007.05992.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2007.05992.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17697116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17697116"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tobias Löfstedt, Erik Fredlund, Rosa Noguera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.02.015"}], "href": "https://doi.org/10.1016/j.yexcr.2009.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19254710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19254710"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Michael B Armstrong, Rajen J Mody, D Christian Ellis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.11606"}], "href": "https://doi.org/10.1593/neo.11606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24403858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24403858"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zhenzhen Hu, Na Dong, Dian Lu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mxi1-0 regulates the growth of human umbilical vein endothelial cells through extracellular signal-regulated kinase 1/2 (ERK1/2) and interleukin-8 (IL-8)-dependent pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0178831"}], "href": "https://doi.org/10.1371/journal.pone.0178831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28575053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28575053"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhenzhen Hu, Feng Wang, Zhen Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXO3a-dependent up-regulation of Mxi1-0 promotes hypoxia-induced apoptosis in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2018.08.009"}], "href": "https://doi.org/10.1016/j.cellsig.2018.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30118760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30118760"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lin-Ping Xu, Yan Sun, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYC and MXI1 protein expression: potential prognostic significance in women with breast cancer in China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res Treat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000360207"}], "href": "https://doi.org/10.1159/000360207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24685915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24685915"}]}]}]}
Synonyms	MXD2, MXI, BHLHC11
Proteins	MXI1_HUMAN
NCBI Gene ID	4601
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MXI1 has 11,894 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for MXI1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MXI1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MXI1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MXI1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MXI1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MXI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MXI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MXI1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MXI1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MXI1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MXI1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MXI1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MXI1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MXI1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MXI1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MXI1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MXI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MXI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MXI1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MXI1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MXI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MXI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MXI1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MXI1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MXI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MXI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MXI1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MXI1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MXI1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MXI1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MXI1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MXI1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MXI1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MXI1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MXI1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MXI1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MXI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MXI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MXI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MXI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MXI1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MXI1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.