{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that MXRA7 plays important roles in tissue homeostasis and inflammatory regulation in the skin. In normal human epidermis, MXRA7 is widely expressed with highest levels in the basal layer, whereas in psoriatic lesions its distribution is markedly altered—with loss in the basal stem cell compartment and enhanced expression in suprabasal keratinocytes—suggesting that MXRA7 functions as a negative modulator that helps restrain the excessive activation of epidermal keratinocytes during psoriatic inflammation. This observation is further supported by murine models in which MXRA7 deficiency led to more severe psoriasis‐like disease and increased expression of pro‐psoriatic cytokines."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn hematologic malignancies, MXRA7 appears to be closely linked with leukemic cell biology. In acute B lymphoblastic leukemia models, research is underway to elucidate how MXRA7 influences the growth and biological functions of leukemic cells, suggesting its potential involvement in the pathogenesis of this disease. Similarly, in acute myeloid leukemia—especially in acute promyelocytic leukemia—MXRA7 is highly expressed and correlates with poor overall survival. Functional studies indicate that modulation of MXRA7 expression can affect drug-induced apoptosis and all-trans retinoic acid–induced differentiation, likely through altering key regulators such as PML‐RARα, PML, and RARα, as well as downstream genes that control cell growth and differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in skin pathology and leukemia, MXRA7 has been implicated in immune cell differentiation. In vitro studies using human monocytic THP-1 cells demonstrate that the knockdown of MXRA7 not only reduces proliferation but also enhances cell adhesion—likely via upregulation of adhesion molecules such as VCAM-1 and ICAM-1—and promotes differentiation toward macrophages, particularly skewing them toward a proinflammatory (M1) phenotype. This effect appears to involve key signaling pathways including NF-κB and MAPK, underscoring a potential mechanism by which MXRA7 modulates innate immune responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinling Ning, Ying Shen, Ting Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.13687"}], "href": "https://doi.org/10.1111/exd.13687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29781547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29781547"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kun-Peng Ma, Zhen-Jiang Sun, Ying Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MXRA7"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2023.01.008"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.01.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36765476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36765476"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhenjiang Sun, Dandan Lin, Ying Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2023.07.001"}], "href": "https://doi.org/10.1016/j.exphem.2023.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37419299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37419299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhenjiang Sun, Peng Ke, Ying Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MXRA7 is involved in monocyte-to-macrophage differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2024.05.001"}], "href": "https://doi.org/10.1016/j.molimm.2024.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38735126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38735126"}]}]}]}