MYDGF Gene

Name	myeloid-derived growth factor
Description	The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYDGF, originally identified as a secreted protein encoded by c19orf10, is produced by bone marrow–derived monocytes and macrophages and functions in a paracrine manner to repair injured tissues. In the heart, MYDGF protects cardiomyocytes from apoptosis and promotes tissue repair after myocardial infarction, thereby reducing infarct size and preserving contractile function. Its receptor binding epitope has been localized through structure‐guided mutational studies, underscoring its potential for protein‐based therapeutic applications in ischemic heart repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cardioprotection, MYDGF has been implicated in diverse pathophysiological settings. In hepatocellular carcinoma, studies have shown that MYDGF is upregulated—often as a result of hypoxic conditions—and contributes to tumor progression by enhancing cancer stem cell self‐renewal, promoting cell proliferation through Akt/mitogen‐activated protein kinase pathways, and remodeling the tumor microenvironment via increased angiogenesis and macrophage recruitment. In parallel, MYDGF also exerts systemic metabolic benefits by stimulating glucagon-like peptide-1 (GLP-1) production via PKA/GSK-3β/β-catenin and MEK/ERK pathways, thereby improving glucose tolerance and lipid metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural investigations using both X-ray crystallography and NMR spectroscopy have revealed that MYDGF possesses a unique 10-stranded β-sandwich fold with distinctive surface features that likely mediate its receptor interactions. Notably, these studies have provided the molecular framework for designing enhanced MYDGF variants for therapeutic applications. Moreover, recent work has identified MYDGF as a mechanically induced angiocrine signal that supports liver regeneration following partial hepatectomy, and its potential protective role is currently being examined in the context of renal ischemia/reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mortimer Korf-Klingebiel, Marc R Reboll, Stefanie Klede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3778"}], "href": "https://doi.org/10.1038/nm.3778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25581518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25581518"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rebecca Ebenhoch, Abbas Akhdar, Marc R Reboll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-13343-7"}], "href": "https://doi.org/10.1038/s41467-019-13343-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31772377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31772377"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xu Wang, Jie Mao, Tao Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.49327"}], "href": "https://doi.org/10.7150/thno.49327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33391471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33391471"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hajime Sunagozaka, Masao Honda, Taro Yamashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25830"}], "href": "https://doi.org/10.1002/ijc.25830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21128247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21128247"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li Wang, Yixiang Li, Bei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqaa003"}], "href": "https://doi.org/10.1210/endocr/bqaa003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31913472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31913472"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jinling Xu, Yanzhuo Song, Sheng Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2023.12.005"}], "href": "https://doi.org/10.1016/j.cytogfr.2023.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38185568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38185568"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Valeriu Bortnov, Marco Tonelli, Woonghee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-13577-5"}], "href": "https://doi.org/10.1038/s41467-019-13577-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819058"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jingwen Wang, Ruiyang Ma, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting Inflammation and Apoptosis via the Akt Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transplantation (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/TP.0000000000004497"}], "href": "https://doi.org/10.1097/TP.0000000000004497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36698245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36698245"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Linda Große-Segerath, Paula Follert, Kristina Behnke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-44760-y"}], "href": "https://doi.org/10.1038/s41467-024-44760-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38316785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38316785"}]}]}]}
Synonyms	IL25, IL27, EUROIMAGE1875335, R33729_1, C19ORF10, IL27W, SF20
Proteins	MYDGF_HUMAN
NCBI Gene ID	56005
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MYDGF has 7,145 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for MYDGF from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MYDGF Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYDGF gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYDGF gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MYDGF gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MYDGF gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MYDGF gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYDGF gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MYDGF gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYDGF gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYDGF gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MYDGF gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYDGF gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MYDGF gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MYDGF protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MYDGF gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYDGF gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MYDGF gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MYDGF gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MYDGF gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MYDGF protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MYDGF protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MYDGF protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MYDGF protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MYDGF gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MYDGF protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MYDGF gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MYDGF gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MYDGF gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MYDGF gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MYDGF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MYDGF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MYDGF gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYDGF gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MYDGF gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MYDGF from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MYDGF gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MYDGF gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MYDGF gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MYDGF from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MYDGF gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MYDGF gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.