{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYEOV has emerged as an oncogene that is aberrantly overexpressed in a wide range of malignancies. In gastric adenocarcinoma, elevated MYEOV expression is associated with increased cell proliferation and invasion, and its siRNA‐mediated suppression markedly impairs these tumorigenic properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, MYEOV overexpression contributes to enhanced proliferation and invasion, with knockdown studies revealing significant reductions in these aggressive phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, MYEOV is frequently coamplified with CCND1, although its transcription can be restrained by DNA methylation in certain contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In neuroblastoma, increased MYEOV levels correlate with enhanced cell proliferation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in multiple myeloma, its dysregulation has been identified as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, MYEOV genomic rearrangements—for instance, its juxtaposition with the human oncogene hst (fgf4)—further underscore its involvement in tumorigenesis, a phenomenon also observed in head and neck cancers where higher mutation frequencies and expression levels of MYEOV correlate with poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of lung cancers, MYEOV plays a distinct role in promoting metastasis and tumor progression. In non‐small cell lung cancer (NSCLC), MYEOV functions as a competing endogenous RNA that sequesters miR‑30c‑2‑3p, thereby relieving suppression of targets involved in TGF‑β signaling and leading to enhanced cell invasion and dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Additional studies in NSCLC have linked high MYEOV expression with adverse clinical outcomes and altered immune infiltration profiles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In lung adenocarcinoma, aberrant transcriptional activation of MYEOV mediated by cancer‐specific super‐enhancers not only drives proliferation but also restrains ferroptosis by modulating the autophagic degradation of GPX4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic ductal adenocarcinoma (PDAC), MYEOV overexpression is similarly linked to aggressive tumor behavior. It is upregulated via promoter hypomethylation and exerts its oncogenic role by interacting with transcription factors such as SOX9 to enhance the expression of downstream targets like HES1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " High MYEOV expression in PDAC correlates with poor differentiation, lymph node metastasis, and reduced overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Furthermore, MYEOV has been shown to promote PDAC cell proliferation, invasion, and migration through a mechanism involving the recruitment of MYC to drive transcription of oncogenic miRNAs such as miR‑17‑5p and miR‑93‑5p, supporting its role as a key contributor to pancreatic cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, MYEOV expression is finely regulated at both transcriptional and translational steps. The 5′‐untranslated region of the MYEOV transcript is unusually long and contains several upstream AUGs and strong secondary structure elements. This region not only appears to affect translation initiation—potentially through internal ribosomal entry site–like activity—but also demonstrates unexpected promoter activity that may contribute to the gene's complex regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Leyden, D Murray, A Moss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Net1 and Myeov: computationally identified mediators of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603054"}], "href": "https://doi.org/10.1038/sj.bjc.6603054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16552434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16552434"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alan C Moss, Garrett Lawlor, David Murray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.04.094"}], "href": "https://doi.org/10.1016/j.bbrc.2006.04.094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16678123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16678123"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Garrett Lawlor, Peter P Doran, Padraic MacMathuna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV (myeloma overexpressed gene) drives colon cancer cell migration and is regulated by PGE2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-29-81"}], "href": "https://doi.org/10.1186/1756-9966-29-81"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20569498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20569498"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Johannes W G Janssen, Issei Imoto, Jun Inoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s100380200065"}], "href": "https://doi.org/10.1007/s100380200065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12202983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12202983"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Junko Takita, Yuyan Chen, Jun Okubo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2011.01995.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2011.01995.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21624008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21624008"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jerome Moreaux, Dirk Hose, Amélie Bonnefond, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV is a prognostic factor in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2010.09.002"}], "href": "https://doi.org/10.1016/j.exphem.2010.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20854874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20854874"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marcus Brecht, Agatha C M Steenvoorden, Susanne Luf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rearrangement and expression of myeov and hst in NIH/3T3 transfectants: a caveat for the interpretation of DNA transfection analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17390055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17390055"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Deming Ou, Ying Wu, Jibin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-023-10484-9"}], "href": "https://doi.org/10.1007/s10528-023-10484-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37667096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37667096"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lishan Fang, Shanshan Wu, Xun Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0484-9"}], "href": "https://doi.org/10.1038/s41388-018-0484-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30181549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30181549"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rui Zhang, Aiqing Ma "}, {"type": "b", "children": [{"type": "t", "text": "High expression of MYEOV reflects poor prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.145337"}], "href": "https://doi.org/10.1016/j.gene.2020.145337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33278551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33278551"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shuimei Luo, Yang Luo, Ziming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.216811"}], "href": "https://doi.org/10.1016/j.canlet.2024.216811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38490328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38490328"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Erbo Liang, Yishi Lu, Yanqiang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01443-4"}], "href": "https://doi.org/10.1038/s41388-020-01443-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32879444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32879444"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rui Tang, Jianmei Ji, Jun Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1757243"}], "href": "https://doi.org/10.1080/15384101.2020.1757243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32420813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32420813"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hongzhang Shen, Fuqiang Ye, Dongchao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04387-z"}], "href": "https://doi.org/10.1038/s41419-021-04387-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34930894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34930894"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shoichiro Tange, Tomomi Hirano, Masashi Idogawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-10433-6"}], "href": "https://doi.org/10.1186/s12885-022-10433-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36698109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36698109"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Rogério Alves de Almeida, Tanja Heuser, Rüdiger Blaschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of MYEOV protein synthesis by upstream open reading frames."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M511467200"}], "href": "https://doi.org/10.1074/jbc.M511467200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16275643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16275643"}]}]}]}