MYH3 Gene

HGNC Family	Myosins (MYH, MYO)
Name	myosin, heavy chain 3, skeletal muscle, embryonic
Description	Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYH3 encodes the embryonic isoform of myosin heavy chain, a molecular motor essential for force generation in striated muscle during fetal development. This isoform is normally expressed during embryonic life, where it plays a fundamental role in muscle contraction and proper myofiber force production, as evidenced by its association with congenital joint contractures and related musculoskeletal abnormalities (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDisruptive mutations in MYH3 have been linked to several forms of distal arthrogryposis, including Freeman–Sheldon and Sheldon–Hall syndromes. Structural and kinetic analyses indicate that most pathogenic variants perturb myosin’s catalytic function—slowing ATP hydrolysis and delaying detachment kinetics—which leads to prolonged contraction and an inability to properly deactivate thin filament activity, ultimately resulting in joint contractures and muscle dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n \nIn addition to its role in muscle contraction, MYH3 appears to be involved in skeletal development. Mutations in MYH3 are not only associated with contracture syndromes but also with disorders marked by multiple pterygia and vertebral or carpal fusions, suggesting that embryonic myosin has important functions in both myofiber performance and the regulation of bone and joint formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n \nEmerging studies further expand the phenotypic spectrum of MYH3-associated disorders. Beyond classical contractures, MYH3 mutations have been implicated in a range of developmental anomalies—including atrial septal defects and variable skeletal fusions—highlighting a role for this myosin in both muscle and nonmuscle tissues. These observations underscore the dosage- and domain-dependent effects of MYH3 variants on the development of the musculoskeletal system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "17"}]}, {"type": "t", "text": "\n \nCollectively, the MYH3‐associated myosinopathies represent a clinically heterogeneous continuum ranging from severe congenital contracture syndromes to disorders featuring skeletal fusions. This spectrum emphasizes the critical developmental role of embryonic myosin not only in fetal muscle function but also in coordinating aspects of skeletal morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Homa Tajsharghi, Eva Kimber, Anna-Karin Kroksmark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myosin myopathy that persists postnatally."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Neurol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archneur.65.8.1083"}], "href": "https://doi.org/10.1001/archneur.65.8.1083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18695058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18695058"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "William Shyy, Kai Wang, Val C Sheffield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Orthop (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/BPO.0b013e3181d35e3f"}], "href": "https://doi.org/10.1097/BPO.0b013e3181d35e3f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20357587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20357587"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David M Alvarado, Jillian G Buchan, Christina A Gurnett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies an MYH3 mutation in a family with distal arthrogryposis type 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Joint Surg Am (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2106/JBJS.J.02004"}], "href": "https://doi.org/10.2106/JBJS.J.02004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21531865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21531865"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alice W Racca, Anita E Beck, Margaret J McMillin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv084"}], "href": "https://doi.org/10.1093/hmg/ddv084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25740846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25740846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jonathan Walklate, Carlos Vera, Marieke J Bloemink, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.707489"}], "href": "https://doi.org/10.1074/jbc.M115.707489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26945064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26945064"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jennifer Hague, Isabelle Delon, Kim Brugger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecularly proven mosaicism in phenotypically normal parent of a girl with Freeman-Sheldon Syndrome caused by a pathogenic MYH3 mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37631"}], "href": "https://doi.org/10.1002/ajmg.a.37631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26996280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26996280"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jessica X Chong, Lindsay C Burrage, Anita E Beck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autosomal-Dominant Multiple Pterygium Syndrome Is Caused by Mutations in MYH3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.04.004"}], "href": "https://doi.org/10.1016/j.ajhg.2015.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25957469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25957469"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Malgorzata Pokrzywa, Michaela Norum, Johan Lengqvist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmental MYH3 Myopathy Associated with Expression of Mutant Protein and Reduced Expression Levels of Embryonic MyHC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0142094"}], "href": "https://doi.org/10.1371/journal.pone.0142094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26544689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26544689"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Raphael Carapito, Alice Goldenberg, Nicodème Paul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2016.84"}], "href": "https://doi.org/10.1038/ejhg.2016.84"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27381093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27381093"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jennifer Zieba, Wenjuan Zhang, Jessica X Chong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep41803"}], "href": "https://doi.org/10.1038/srep41803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28205584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28205584"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eva Kimber, Homa Tajsharghi, Anna-Karin Kroksmark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distal arthrogryposis: clinical and genetic findings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Paediatr (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1651-2227.2012.02708.x"}], "href": "https://doi.org/10.1111/j.1651-2227.2012.02708.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22519952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22519952"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marcello Scala, Andrea Accogli, Elisa De Grandis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel pathogenic MYH3 mutation in a child with Sheldon-Hall syndrome and vertebral fusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38593"}], "href": "https://doi.org/10.1002/ajmg.a.38593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29314551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29314551"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Masaki Takagi, Satoshi Shimomura, Ryuji Fukuzawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel truncating mutation in MYH3 causes spondylocarpotarsal synostosis syndrome with basilar invagination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-018-0513-0"}], "href": "https://doi.org/10.1038/s10038-018-0513-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30228365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30228365"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wen-Bo Wang, Ling-Chi Kong, Rong-Tai Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel pathogenic mutation of the MYH3 gene in a family with distal arthrogryposis type 2B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10820"}], "href": "https://doi.org/10.3892/mmr.2019.10820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31746383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31746383"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sathiya Maran, Robson Ee, Siti Aisyah Faten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the tail domain of MYH3 contributes to atrial septal defect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0230982"}], "href": "https://doi.org/10.1371/journal.pone.0230982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32315303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32315303"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jing Zhang, Wen-Qi Chen, Si-Wen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel pathogenic variant in the MYH3 gene in a five-generation family with CPSFS1A (Contractures, Pterygia, and Spondylocarpotarsal Fusion Syndrome 1A)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.1440"}], "href": "https://doi.org/10.1002/mgg3.1440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32767732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32767732"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anna H Hakonen, Johanna Lehtonen, Sirpa Kivirikko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recessive MYH3 variants cause \"Contractures, pterygia, and variable skeletal fusions syndrome 1B\" mimicking Escobar variant multiple pterygium syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61836"}], "href": "https://doi.org/10.1002/ajmg.a.61836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32902138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32902138"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Qing-Bing He, Cai-Hong Wu, Dong-Lan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional assessment of a novel biallelic MYH3 variation causing CPSKF1B (contractures, pterygia, and spondylocarpotarsal fusion syndrome1B)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.2401"}], "href": "https://doi.org/10.1002/mgg3.2401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38444278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38444278"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yafen Yu, Weiwei Chen, Bao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutaneous Calcium/Calmodulin-Dependent Protein Kinase II-γ-Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202306772"}], "href": "https://doi.org/10.1002/advs.202306772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38544478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38544478"}]}]}]}
Synonyms	HEMHC, DA8, DA2B, MYHSE1, MYHC-EMB, DA2A, SMHCE
Proteins	MYH3_HUMAN
NCBI Gene ID	4621
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MYH3 has 4,839 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for MYH3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MYH3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYH3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYH3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MYH3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MYH3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MYH3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYH3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MYH3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYH3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYH3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MYH3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MYH3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MYH3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYH3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MYH3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MYH3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MYH3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MYH3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MYH3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MYH3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MYH3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MYH3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MYH3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYH3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MYH3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MYH3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MYH3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MYH3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MYH3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MYH3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MYH3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MYH3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MYH3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MYH3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MYH3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYH3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MYH3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MYH3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MYH3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MYH3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MYH3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.