MYO1E Gene

HGNC Family	Myosins (MYH, MYO)
Name	myosin IE
Description	This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYO1E is a nonmuscle class I myosin characterized by a long tail that includes an SH3 domain, endowing it with the ability to interact with proteins involved in membrane remodeling. Kinetic studies of a truncated MYO1E construct reveal that its motor domain is tuned for rapid actin‐dependent sliding, with a low actin affinity in the presence of ATP and accelerated ADP release. These properties suggest a role for MYO1E in regions of highly cross‐linked actin where rapid movement is necessary."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its motor function, the tail domain of MYO1E mediates direct association with membrane lipids. Detailed analyses show that MYO1E binds tightly to vesicles enriched in anionic phospholipids such as phosphatidylinositol 4,5‐bisphosphate, with the binding occurring via nonspecific electrostatic interactions rather than a stereospecific recognition of phosphoinositide headgroups. This lipid interaction is critical for its subcellular localization and its involvement in endocytic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMYO1E plays an essential role in the function and integrity of podocytes, the specialized cells of the glomerular filtration barrier. Genetic studies have identified mutations in the MYO1E gene—such as those impairing ligand binding in the motor domain—in patients with steroid‐resistant nephrotic syndrome and familial focal segmental glomerulosclerosis. These findings, together with demonstrations of MYO1E as a key component of the podocyte cytoskeleton, highlight its importance in maintaining cell adhesion and cytoskeletal dynamics in renal function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in membrane binding and podocyte biology, MYO1E contributes importantly to cell motility and invasive behavior. Its translocation to the tips of lamellipodia is regulated by interactions with signaling molecules—for instance, the dissociation of MYO1E from the inhibitory adaptor SH3P2 facilitates its recruitment to regions of active actin polymerization. Consequently, deregulated MYO1E expression has been implicated in tumor promotion, with elevated levels correlating with increased malignancy in basal‐like breast cancer and adverse outcomes in non–small cell lung carcinoma. Furthermore, MYO1E localization at podosomes underscores its role in organizing actin structures that are essential for cell migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mohammed El Mezgueldi, Nanyun Tang, Steven S Rosenfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The kinetic mechanism of Myo1e (human myosin-IC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200713200"}], "href": "https://doi.org/10.1074/jbc.M200713200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11940582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11940582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mira Krendel, Emily K Osterweil, Mark S Mooseker "}, {"type": "b", "children": [{"type": "t", "text": "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2007.01.021"}], "href": "https://doi.org/10.1016/j.febslet.2007.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17257598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17257598"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizabeth A Feeser, Cherry Mae G Ignacio, Mira Krendel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myo1e binds anionic phospholipids with high affinity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi1012657"}], "href": "https://doi.org/10.1021/bi1012657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20860408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20860408"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Simone Sanna-Cherchi, Katelyn E Burgess, Shannon N Nees, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2011.148"}], "href": "https://doi.org/10.1038/ki.2011.148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21697813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21697813"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jianhua Mao, Dayan Wang, Parikka Mataleena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0072750"}], "href": "https://doi.org/10.1371/journal.pone.0072750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23977349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23977349"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Feng Zhao, Zi-Hua Yu, Yong-Hui Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Mutational analysis of MYO1E in Chinese children with familial steroid-resistant nephrotic syndrome]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Dang Dai Er Ke Za Zhi (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24750828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24750828"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mira Krendel, Sabine Leh, Michael E Garone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Focal segmental glomerulosclerosis and proteinuria associated with Myo1E mutations: novel variants and histological phenotype analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Nephrol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00467-022-05634-x"}], "href": "https://doi.org/10.1007/s00467-022-05634-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35723736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35723736"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pei-Ju Liu, Laura K Gunther, Michael E Garone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Steroid-Resistant Nephrotic Syndrome-Associated "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MYO1E"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Mutations Have Differential Effects on Myosin 1e Localization, Dynamics, and Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2021111505"}], "href": "https://doi.org/10.1681/ASN.2021111505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36316095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36316095"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jessica L Ouderkirk-Pecone, Gregory J Goreczny, Sharon E Chase, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10139"}], "href": "https://doi.org/10.18632/oncotarget.10139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27329840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27329840"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Susumu Tanimura, Junya Hashizume, Naoya Arichika, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201503123"}], "href": "https://doi.org/10.1083/jcb.201503123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27502487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27502487"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yage Zhang, Fakun Cao, Yuhuan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E18-06-0398"}], "href": "https://doi.org/10.1091/mbc.E18-06-0398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30601698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30601698"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ignacio Jusue-Torres, Richies Tiv, Julio C Ricarte-Filho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-30765-y"}], "href": "https://doi.org/10.1038/s41598-023-30765-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36914720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36914720"}]}]}]}
Synonyms	MYO1C, HUNCM-IC, FSGS6
Proteins	MYO1E_HUMAN
NCBI Gene ID	4643
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MYO1E has 13,201 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 136 datasets.

Click the + buttons to view associations for MYO1E from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MYO1E Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1E gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1E gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MYO1E gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MYO1E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MYO1E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1E gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MYO1E gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYO1E gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYO1E gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MYO1E gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYO1E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MYO1E gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MYO1E protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MYO1E gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYO1E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MYO1E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MYO1E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MYO1E gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MYO1E gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MYO1E protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MYO1E gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MYO1E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MYO1E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MYO1E protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MYO1E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MYO1E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MYO1E protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYO1E gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MYO1E gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MYO1E gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MYO1E gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MYO1E gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MYO1E protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MYO1E gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MYO1E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MYO1E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MYO1E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MYO1E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MYO1E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MYO1E gene from the ENCODE Histone Modification Site Profiles dataset.