MYO1F Gene

HGNC Family	Myosins (MYH, MYO)
Name	myosin IF
Description	Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYO1F is an unconventional long‐tailed myosin that contributes to diverse cellular processes. In the auditory system, rare heterozygous missense mutations in MYO1F have been documented in patients with bilateral sensorineural hearing loss, with homology modeling suggesting that these mutations may disrupt the ATP‐binding site and consequently affect ATPase activity and actin binding functions ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In parallel, in familial non‐medullary thyroid cancer, a novel heterozygous mutation in MYO1F (p.Gly134Ser) was found to alter mitochondrial morphology and function—marked by increased mitochondrial mass and reactive oxygen species—that promotes enhanced colony formation, invasion, and anchorage‐independent growth, findings validated in zebrafish models ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in sensory organ function and tumorigenesis, MYO1F has emerged as part of a four‐gene expression signature in peripheral blood mononuclear cells that distinguishes patients with obstructive coronary artery disease and ST‐segment elevation myocardial infarction from those with stable coronary artery disease. Elevated mRNA levels of MYO1F, together with other marker genes, suggest its potential utility as a noninvasive prognostic and diagnostic biomarker in cardiovascular pathology ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, MYO1F plays key roles within the immune system, particularly in mast cells. Its contribution to mast cell function is multifaceted: MYO1F localizes to cortical F‐actin and is critical for proper degranulation by facilitating the reassembly of the cortical actin ring, regulating granule positioning, and promoting mitochondrial fission and translocation—processes that involve activation of the GTPase Cdc42 and modulation of AKT and DRP1 signaling ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. Additionally, MYO1F interacts with the adaptor protein 3BP2 to regulate stem cell factor‐dependent mast cell adhesion and migration, effects that are partly mediated by its regulation of β1 and β7 integrins ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, studies of Aspergillus fumigatus keratitis have revealed that MYO1F is expressed in the cornea and may play a significant role in immune cell motility and antifungal defense, further emphasizing the protein’s involvement in innate immunity and inflammatory responses ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "].\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cristina Zadro, Maria Stella Alemanno, Emanuele Bellacchio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Are MYO1C and MYO1F associated with hearing loss?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2008.10.017"}], "href": "https://doi.org/10.1016/j.bbadis.2008.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19027848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19027848"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chiara Diquigiovanni, Christian Bergamini, Cecilia Evangelisti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31548"}], "href": "https://doi.org/10.1002/ijc.31548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29672841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29672841"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xian-Gang Mo, Wei Liu, Yao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29128"}], "href": "https://doi.org/10.1002/jcb.29128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31245869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31245869"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Arnau Navinés-Ferrer, Erola Ainsua-Enrich, Eva Serrano-Candelas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2001211"}], "href": "https://doi.org/10.4049/jimmunol.2001211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33941653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33941653"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Arnau Navinés-Ferrer, Erola Ainsua-Enrich, Eva Serrano-Candelas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.01058"}], "href": "https://doi.org/10.3389/fimmu.2019.01058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31143189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31143189"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wenting Liu, Hua Yang, Qiang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2024.113094"}], "href": "https://doi.org/10.1016/j.intimp.2024.113094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39276460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39276460"}]}]}]}
Proteins	MYO1F_HUMAN
NCBI Gene ID	4542
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MYO1F has 6,123 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for MYO1F from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MYO1F Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1F gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1F gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MYO1F gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MYO1F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MYO1F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYO1F gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MYO1F gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYO1F gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYO1F gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MYO1F gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYO1F gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MYO1F gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MYO1F gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYO1F gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MYO1F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MYO1F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MYO1F gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MYO1F protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MYO1F protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MYO1F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MYO1F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MYO1F gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MYO1F gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MYO1F gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MYO1F gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MYO1F gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MYO1F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MYO1F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MYO1F gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MYO1F gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MYO1F gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYO1F gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MYO1F gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MYO1F from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MYO1F gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MYO1F gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MYO1F gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MYO1F gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MYO1F from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MYO1F gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.