{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNAA10, also known as ARD1, is the catalytic core of the NatA complex responsible for the co‐translational N‑terminal acetylation of a large fraction of eukaryotic proteins. Through its association with auxiliary subunits (such as NAA15/NATH) and binding partners like HYPK, NAA10 helps determine substrate specificity and regulates protein stability, folding, and interactions. Moreover, its activity is not strictly limited to co‐translational events; studies have shown that isolated NAA10 may also exhibit post‑translational acetylation—for example, modifying actin N‑termini and participating in noncanonical modifications such as N‑terminal propionylation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSeveral laboratories have examined the interplay between NAA10 and hypoxia‐inducible factor‐1α (HIF‑1α). Some studies indicate that NAA10 directly binds HIF‑1α and, via acetylation, can enhance its interaction with ubiquitin ligases—thereby promoting degradation under normoxic conditions—while other reports find that modulation of NAA10 expression does not necessarily alter HIF‑1α stability. In addition, NAA10 interaction with HIF‑1α appears to influence other signaling pathways such as Wnt, suggesting that oxygen availability and even post‐translational modifications (for example, oxygen‐dependent hydroxylation events) might re‐tune its substrate preferences."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in NAA10 have been directly linked to a spectrum of X‑linked developmental disorders. Pathogenic missense variants—including those associated with Ogden syndrome, Lenz microphthalmia syndrome, and other forms of intellectual disability—lead to impaired acetyltransferase activity and reduced enzyme stability, with the extent of catalytic disruption correlating with phenotypic severity. Such findings underscore the crucial developmental role of N‑terminal acetylation in normal human growth and organogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "22"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncologic arena, NAA10 displays context‐dependent roles that can be either pro‑tumorigenic or tumor‑suppressive. On one hand, it modulates cell proliferation, survival, and chemoresistance through acetylation of key regulatory proteins including DNMT1, TSC2, and the androgen receptor; on the other, NAA10 has been shown to suppress migratory activity by disrupting protein complexes involved in cell motility, while certain studies have linked its expression level to improved clinical outcome. In addition, differential regulation of NAA10 by microRNAs and its ability to control factors such as MCL1 further illustrate its multifaceted involvement in cancer development and progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "37"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional layers of regulation further expand NAA10’s functional repertoire. Auto‑acetylation of NAA10 is critical for its full enzymatic activity and influences downstream events such as cyclin D1 expression, while interactions with other proteins—notably in the context of the amyloid precursor protein (APP) or the chaperone Hsp70—highlight roles in protein homeostasis, stress responses, and even the regulation of amyloid‑β generation. These findings, together with comprehensive reviews of its dual acetyltransferase and lysine‑targeting activities, emphasize that NAA10 is a multifunctional enzyme whose precise regulatory mechanisms are finely tuned by its post‑translational modifications and complex formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "38", "end_ref": "41"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Sekine, S Saito, A Iida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s100380170065"}], "href": "https://doi.org/10.1007/s100380170065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11393533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11393533"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Thomas Arnesen, Dave Anderson, Christian Baldersheim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20041071"}], "href": "https://doi.org/10.1042/BJ20041071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15496142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15496142"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "T Arnesen, D Gromyko, F Pendino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209469"}], "href": "https://doi.org/10.1038/sj.onc.1209469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16518407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16518407"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas Arnesen, Kristian K Starheim, Petra Van Damme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01199-09"}], "href": "https://doi.org/10.1128/MCB.01199-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20154145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20154145"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Petra Van Damme, Rune Evjenth, Håvard Foyn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M110.004580"}], "href": "https://doi.org/10.1074/mcp.M110.004580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21383206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21383206"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Håvard Foyn, Petra Van Damme, Svein I Støve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M112.019299"}], "href": "https://doi.org/10.1074/mcp.M112.019299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23043182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23043182"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Felix Alexander Weyer, Andrea Gumiero, Karine Lapouge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of HypK regulating N-terminal acetylation by the NatA complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15726"}], "href": "https://doi.org/10.1038/ncomms15726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28585574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28585574"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sunbin Deng, Robert S Magin, Xuepeng Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2019.04.014"}], "href": "https://doi.org/10.1016/j.str.2019.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31155310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31155310"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Joo Won Jeong, Moon Kyoung Bae, Mee Young Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(02)01085-1"}], "href": "https://doi.org/10.1016/s0092-8674(02"}, {"type": "t", "text": "01085-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12464182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12464182"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tim S Fisher, Shelley Des Etages, Lisa Hayes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of ARD1 function in hypoxia response using retroviral RNA interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412055200"}], "href": "https://doi.org/10.1074/jbc.M412055200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15755738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15755738"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rebecca Bilton, Nathalie Mazure, Eric Trottier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504482200"}], "href": "https://doi.org/10.1074/jbc.M504482200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15994306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15994306"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Thomas Arnesen, Xianguo Kong, Rune Evjenth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.10.036"}], "href": "https://doi.org/10.1016/j.febslet.2005.10.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16288748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16288748"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ji-Hong Lim, Yang-Sook Chun, Jong-Wan Park "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-6234"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-6234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18593917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18593917"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jengmin Kang, Yang-Sook Chun, June Huh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2018.09.002"}], "href": "https://doi.org/10.1016/j.redox.2018.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30237125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30237125"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Alan F Rope, Kai Wang, Rune Evjenth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.05.017"}], "href": "https://doi.org/10.1016/j.ajhg.2011.05.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21700266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21700266"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Taraneh Esmailpour, Hamidreza Riazifar, Linan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2013-101660"}], "href": "https://doi.org/10.1136/jmedgenet-2013-101660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24431331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24431331"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Bernt Popp, Svein I Støve, Sabine Endele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2014.150"}], "href": "https://doi.org/10.1038/ejhg.2014.150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25099252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25099252"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jillian P Casey, Svein I Støve, Catherine McGorrian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep16022"}], "href": "https://doi.org/10.1038/srep16022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26522270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26522270"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chloé Saunier, Svein Isungset Støve, Bernt Popp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23001"}], "href": "https://doi.org/10.1002/humu.23001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27094817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27094817"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Svein Isungset Støve, Marina Blenski, Asbjørg Stray-Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-018-0136-0"}], "href": "https://doi.org/10.1038/s41431-018-0136-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748569"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jennifer J Johnston, Kathleen A Williamson, Christopher M Chou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAA10 polyadenylation signal variants cause syndromic microphthalmia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2018-105836"}], "href": "https://doi.org/10.1136/jmedgenet-2018-105836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30842225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30842225"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Gholson J Lyon, Marall Vedaie, Travis Beisheim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-023-01368-y"}], "href": "https://doi.org/10.1038/s41431-023-01368-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37130971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37130971"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Min Yu, Junli Gong, Mingxing Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or_00000303"}], "href": "https://doi.org/10.3892/or_00000303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19287988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19287988"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Dong Hoon Shin, Yang-Sook Chun, Kyoung-Hwa Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007451"}], "href": "https://doi.org/10.1371/journal.pone.0007451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19826488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19826488"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Min Yu, MingXing Ma, Chao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of expression of human arrest-defective-1 (hARD1) protein with breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/07357900902769723"}], "href": "https://doi.org/10.3109/07357900902769723"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19909012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19909012"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Hsu-Ping Kuo, Dung-Fang Lee, Chun-Te Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000590"}], "href": "https://doi.org/10.1126/scisignal.2000590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20145209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20145209"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ji Hae Seo, Jong-Ho Cha, Ji-Hyeon Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3258"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20501853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20501853"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Chung-Fan Lee, Derick S-C Ou, Sung-Bau Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42275"}], "href": "https://doi.org/10.1172/JCI42275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20592467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20592467"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Kuo-Tai Hua, Ching-Ting Tan, Gunnar Johansson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.11.010"}], "href": "https://doi.org/10.1016/j.ccr.2010.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21295525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21295525"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Caiyun Liu, Like Qu, Bin Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined phenotype of 4 markers improves prognostic value of patients with colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MAJ.0b013e31822cb4cd"}], "href": "https://doi.org/10.1097/MAJ.0b013e31822cb4cd"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22261620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22261620"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Zehua Wang, Zemin Wang, Jianhui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1113356109"}], "href": "https://doi.org/10.1073/pnas.1113356109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22315407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22315407"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Huiyu Xu, Beihai Jiang, Lin Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgs144"}], "href": "https://doi.org/10.1093/carcin/bgs144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22496479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22496479"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Petra Van Damme, Svein I Støve, Nina Glomnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M113.035402"}], "href": "https://doi.org/10.1074/mcp.M113.035402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24408909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24408909"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yan Zeng, Li Min, Yong Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgu132"}], "href": "https://doi.org/10.1093/carcin/bgu132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24925029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24925029"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hongju Yang, Qian Li, Jie Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6458"}], "href": "https://doi.org/10.18632/oncotarget.6458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26646451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26646451"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "John S DePaolo, Zehua Wang, Jianhui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12163"}], "href": "https://doi.org/10.18632/oncotarget.12163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27659526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27659526"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Ming-Hsien Chien, Wei-Jiunn Lee, Yi-Chieh Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.06.033"}], "href": "https://doi.org/10.1016/j.canlet.2018.06.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29960050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29960050"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "S-H Shin, H Yoon, Y-S Chun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.456"}], "href": "https://doi.org/10.1038/cddis.2014.456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25341044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25341044"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Max J Dörfel, Gholson J Lyon "}, {"type": "b", "children": [{"type": "t", "text": "The biological functions of Naa10 - From amino-terminal acetylation to human disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2015.04.085"}], "href": "https://doi.org/10.1016/j.gene.2015.04.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25987439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25987439"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12882"}], "href": "https://doi.org/10.1038/ncomms12882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27708256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27708256"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Leah Gottlieb, Ronen Marmorstein "}, {"type": "b", "children": [{"type": "t", "text": "Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2018.04.003"}], "href": "https://doi.org/10.1016/j.str.2018.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29754825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29754825"}]}]}]}