{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWild‐type NAB2 functions as a transcriptional corepressor that critically regulates the activity of early growth response (EGR) transcription factors. Under normal physiological conditions, NAB2 is rapidly induced following EGR activation and, in turn, restrains EGR‐dependent gene expression. This negative feedback mechanism is essential for controlling key cellular processes such as angiogenesis, differentiation, and tissue repair—for instance, by limiting VEGF‐induced gene expression in endothelial cells—and is mediated by direct binding to EGR consensus sites and recruitment of chromatin remodeling complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs), NAB2 is pathologically altered through gene fusion with STAT6. This NAB2–STAT6 fusion joins the EGR‐binding domain of NAB2 to the transcriptional activation domain of STAT6, thereby converting the protein from a repressor into an activator of EGR‐responsive genes. This molecular event is now recognized as the defining and driver mutation in these neoplasms, with a variety of fusion breakpoints correlating with distinct tumor locations, histologic phenotypes, and clinical behaviors. Moreover, the resulting nuclear relocation of STAT6 represents a reliable diagnostic marker that distinguishes SFT/HPC from other mesenchymal tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent studies further demonstrate that specific NAB2–STAT6 fusion variants elicit distinct transcriptional programs. Certain variants lead to significant upregulation of EGR1 itself and mitogenic mediators such as IGF2, thereby contributing to increased cell proliferation and more aggressive tumor behavior. This refined understanding of NAB2’s transformation—from its normal role as an EGR repressor to an oncogenic activator when fused to STAT6—opens avenues for tailored diagnostic and therapeutic strategies in tumors marked by aberrant NAB2 function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Koen Venken, Emilio Di Maria, Emilia Bellone, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Refining the nuclear localization signal within the Egr transcriptional coregulator NAB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13288"}], "href": "https://doi.org/10.1002/1873-3468.13288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30411343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30411343"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dan R Robinson, Yi-Mi Wu, Shanker Kalyana-Sundaram, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.12431"}], "href": "https://doi.org/10.1111/his.12431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24702701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24702701"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuichi Yamada, Kenichi Kohashi, Hirofumi Bekki, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "[Two Cases of Primary Intracranial Solitary Fibrous Tumor:Genetic Examination of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NAB2-STAT6"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Fusion and Its Association with Hemangiopericytoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "No Shinkei Geka (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.11477/mf.1436203090"}], "href": "https://doi.org/10.11477/mf.1436203090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26136329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26136329"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hui-Chun Tai, I-Chieh Chuang, Tse-Ching Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2015.90"}], "href": "https://doi.org/10.1038/modpathol.2015.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26226844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26226844"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shih-Chiang Huang, Chien-Feng Li, Yu-Chien Kao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.572"}], "href": "https://doi.org/10.1002/cam4.572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26686340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26686340"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Keisuke Ishizawa, Yoshitane Tsukamoto, Shunsuke Ikeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Tumor Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10014-015-0247-z"}], "href": "https://doi.org/10.1007/s10014-015-0247-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26746203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26746203"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Karen J Fritchie, Long Jin, Brian P Rubin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuropathol Exp Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnen/nlv026"}], "href": "https://doi.org/10.1093/jnen/nlv026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26883114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26883114"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Satoko Nakada, Hiroshi Minato, Takayuki Nojima "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological differences between variants of the NAB2-STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Tumor Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10014-016-0264-6"}], "href": "https://doi.org/10.1007/s10014-016-0264-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27271270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27271270"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Nicola Fusco, Elena Guerini-Rocco, Claudia Augello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-α expression in pulmonary adenofibromas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.13165"}], "href": "https://doi.org/10.1111/his.13165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28072477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28072477"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Matthias Bieg, Evgeny A Moskalev, Rainer Will, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2020.12.015"}], "href": "https://doi.org/10.1016/j.ajpath.2020.12.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33497701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33497701"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tatiana Georgiesh, Heidi Maria Namløs, Nitin Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pathol.2020.11.010"}], "href": "https://doi.org/10.1016/j.pathol.2020.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33745702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33745702"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Florian Haller, Lea D Schlieben, Fulvia Ferrazzi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Pathol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bpa.13256"}], "href": "https://doi.org/10.1111/bpa.13256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38523251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38523251"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ye-Seul Park, Hyeng-Soo Kim, Ju-Heon Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.03.090"}], "href": "https://doi.org/10.1016/j.bbrc.2020.03.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32216968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32216968"}]}]}]}