NABP2 Gene

Name	nucleic acid binding protein 2
Description	Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHuman NABP2, also known as hSSB1, is a critical single‐stranded DNA binding protein that orchestrates multiple aspects of the DNA damage response. It functions in the repair of double‐strand breaks via homologous recombination, where it is rapidly recruited to sites of damage and becomes phosphorylated by the ATM kinase. NABP2 facilitates the assembly of repair complexes through direct protein–protein interactions, thereby ensuring efficient checkpoint activation and proper resolution of stalled replication forks upon exposure to genotoxic stress, such as ionizing radiation and replication inhibitors. These roles have been demonstrated by analyses of hSSB1 depletion, which results in defective ATM signaling, increased radiosensitivity, compromised recruitment of repair factors like Mre11 and Rad51, and accumulation of DNA strand breaks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMolecular and structural studies have further elucidated that NABP2 achieves its functions by a highly conserved oligonucleotide/oligosaccharide-binding (OB) fold, which mediates direct interaction with single-stranded DNA and modulates its binding through aromatic base-stacking interactions. Detailed investigations have revealed that NABP2 forms distinct protein complexes—such as those including INTS3 and hSSBIP1—and that its precise oligomeric state is regulated in response to oxidative stress. Importantly, depletion of the hSSB1 homologue OBFC2B has been shown to impair homologous recombination efficiency, underscoring the indispensable role of NABP2 in maintaining genomic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central role in DNA repair and replication fork stabilization, NABP2 has been implicated in broader cellular contexts. For instance, its participation in the cellular response to replication stress reinforces cell survival by enabling proper ATR and Chk1 signaling, while emerging evidence also indicates that NABP2 modulates transcriptional programs in hormone‐responsive tissues, such as in prostate cancer. Moreover, genome‐wide association studies have identified NABP2 as a novel candidate influencing human height, indicating that subtle alterations in its function may contribute to phenotypic variation in complex traits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Derek J Richard, Emma Bolderson, Liza Cubeddu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06883"}], "href": "https://doi.org/10.1038/nature06883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18449195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18449195"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongjiang Li, Emma Bolderson, Rakesh Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C109.039586"}], "href": "https://doi.org/10.1074/jbc.C109.039586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19605351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19605351"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jeffrey R Skaar, Derek J Richard, Anita Saraf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INTS3 controls the hSSB1-mediated DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200907026"}], "href": "https://doi.org/10.1083/jcb.200907026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19786574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19786574"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Soo-Hyun Yang, Ruobo Zhou, Judith Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2012.314"}], "href": "https://doi.org/10.1038/emboj.2012.314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23178594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23178594"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Emma Bolderson, Eva Petermann, Laura Croft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku276"}], "href": "https://doi.org/10.1093/nar/gku276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24753408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24753408"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicolas Paquet, Mark N Adams, Vincent Leong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv790"}], "href": "https://doi.org/10.1093/nar/gkv790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26261212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26261212"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nicolas Paquet, Mark N Adams, Nicholas W Ashton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep27446"}], "href": "https://doi.org/10.1038/srep27446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27273218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27273218"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Christine Touma, Ruvini Kariawasam, Adrian X Gimenez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw617"}], "href": "https://doi.org/10.1093/nar/gkw617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27387285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27387285"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chiara Guglielmi, Iacopo Cerri, Monica Evangelista, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-013-2705-9"}], "href": "https://doi.org/10.1007/s10549-013-2705-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24104880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24104880"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Laura V Croft, Nicholas W Ashton, Nicolas Paquet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hSSB1 associates with and promotes stability of the BLM helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12867-017-0090-3"}], "href": "https://doi.org/10.1186/s12867-017-0090-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28506294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28506294"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mark N Adams, Laura V Croft, Aaron Urquhart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.24496"}], "href": "https://doi.org/10.1002/pros.24496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36811381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36811381"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddab202"}], "href": "https://doi.org/10.1093/hmg/ddab202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34270706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34270706"}]}]}]}
Synonyms	SSB1, HSSB1, OBFC2B
Proteins	SOSB1_HUMAN
NCBI Gene ID	79035
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NABP2 has 5,633 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for NABP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NABP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NABP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NABP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NABP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NABP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NABP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NABP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NABP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NABP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NABP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NABP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NABP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NABP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NABP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NABP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NABP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NABP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NABP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NABP2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NABP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NABP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NABP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NABP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NABP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NABP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NABP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NABP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with NABP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NABP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NABP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NABP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NABP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NABP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NABP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NABP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NABP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NABP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NABP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NABP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NABP2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NABP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.