{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nN‐acetyltransferase 10 (NAT10) is a multifunctional enzyme that primarily acts as an RNA cytosine acetyltransferase. It catalyzes the formation of N4‐acetylcytidine (ac4C) modifications on diverse RNA species—including ribosomal RNA and transfer RNA—to regulate pre‐rRNA processing, ribosome assembly, translation fidelity, and even the maintenance of pluripotency. Through these modifications, NAT10 exerts broad control over RNA stability and translation efficiency, thus linking nucleolar events with cellular anabolic status and developmental potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in RNA modification, NAT10 is critically involved in cell cycle regulation and the DNA damage response. By acetylating key regulators such as p53 and MORC2, NAT10 promotes p53 activation, counteracts negative regulators like Mdm2, and reinforces checkpoint control—mechanisms that are essential for maintaining genomic integrity. Moreover, NAT10’s acetylation of proteins such as PARP1 prolongs their half‐life and facilitates recruitment of DNA repair factors, thereby enhancing cellular resistance to genotoxic stress and contributing to phenotypes such as resistance to platinum‐based drugs and even amelioration of defects in premature aging syndromes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant expression and subcellular redistribution of NAT10 have been documented in a wide array of human cancers, where it functions to promote tumorigenesis and metastasis. By installing ac4C modifications on specific oncogenic transcripts, NAT10 enhances the stability and translation of key drivers such as AXL in pancreatic ductal adenocarcinoma, FOXP1 in cervical cancer, MMP1 in oral squamous cell carcinoma, FOXM1 in laryngeal carcinoma, and HMGA1 and KRT8 in prostate cancer. These actions collectively stimulate cell proliferation, epithelial–mesenchymal transition, and invasive behavior. In addition, NAT10 overexpression in malignancies such as colorectal cancer, acute myeloid leukemia, and esophageal cancer as well as its cytoplasmic/membranous redistribution in hepatocellular and bladder carcinomas underscore its prognostic significance and its contribution to aberrant metabolic reprogramming and immunomodulation within the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent studies have also advanced the potential of targeting NAT10 as a therapeutic strategy. Structural analyses and inhibitor screening (for example, using Remodelin) have provided key insights into its acetyltransferase domain, laying the groundwork for novel drug development. Moreover, NAT10 has been implicated in diverse physiological and pathological contexts beyond cancer, including lung epithelial responses to stress, viral replication via modulation of host mRNA stability, heart regeneration and remodeling, as well as inflammatory and autoimmune conditions such as ankylosing spondylitis and rheumatoid arthritis. These broader roles, combined with its dual functions in normal cellular homeostasis and tumorigenesis, underscore both its promise as a biomarker and the challenges of therapeutically modulating its activity without adverse effects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qi Shen, Xingzheng Zheng, Michael A McNutt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.03.007"}], "href": "https://doi.org/10.1016/j.yexcr.2009.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19303003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19303003"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Satoshi Ito, Sayuri Horikawa, Tateki Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C114.602698"}], "href": "https://doi.org/10.1074/jbc.C114.602698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25411247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25411247"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sunny Sharma, Jean-Louis Langhendries, Peter Watzinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv075"}], "href": "https://doi.org/10.1093/nar/gkv075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25653167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25653167"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shiying Cai, Xiaofeng Liu, Chunfeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoacetylation of NAT10 is critical for its function in rRNA transcription activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.092"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27993683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27993683"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky777"}], "href": "https://doi.org/10.1093/nar/gky777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30165671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30165671"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Deng, Long Zhang, Wenying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-022-02586-w"}], "href": "https://doi.org/10.1186/s13046-022-02586-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36609449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36609449"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rucong Liu, Zibaguli Wubulikasimu, Runze Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkad628"}], "href": "https://doi.org/10.1093/nar/gkad628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37497776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37497776"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaofeng Liu, Yuqin Tan, Chunfeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201540505"}], "href": "https://doi.org/10.15252/embr.201540505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26882543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26882543"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qijiong Li, Xiaofeng Liu, Kemin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3570-4"}], "href": "https://doi.org/10.1186/s12885-017-3570-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28859621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28859621"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Delphine Larrieu, Emmanuelle Viré, Samuel Robson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aar5401"}], "href": "https://doi.org/10.1126/scisignal.aar5401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29970603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29970603"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong-Yi Liu, Ying-Ying Liu, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa130"}], "href": "https://doi.org/10.1093/nar/gkaa130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32112098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32112098"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ningning Ma, Haijing Liu, Yaqian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "N"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23126573"}], "href": "https://doi.org/10.3390/ijms23126573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35743017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35743017"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hong Zhang, Wei Hou, Hua-Li Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GSK-3β-regulated N-acetyltransferase 10 is involved in colorectal cancer invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-13-3477"}], "href": "https://doi.org/10.1158/1078-0432.CCR-13-3477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24982245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24982245"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.047"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29634924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29634924"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Peiqi Liang, Rong Hu, Zhuogang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 upregulation indicates a poor prognosis in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Probl Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.currproblcancer.2019.06.006"}], "href": "https://doi.org/10.1016/j.currproblcancer.2019.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31279531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31279531"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chi Jin, Tuo Wang, Dongsheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "4"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "C acetylation of KIF23 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-022-02551-7"}], "href": "https://doi.org/10.1186/s13046-022-02551-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36522719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36522719"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guanzhao Zong, Xing Wang, Xingya Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2023.113620"}], "href": "https://doi.org/10.1016/j.yexcr.2023.113620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37156457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37156457"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wei Wei, Shuishen Zhang, Hui Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.112810"}], "href": "https://doi.org/10.1016/j.celrep.2023.112810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37463108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37463108"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yuanyuan Liu, Xing Wang, Yuying Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-06245-6"}], "href": "https://doi.org/10.1038/s41419-023-06245-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37914704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37914704"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zengpei Li, Dajun Li, Tianbin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2023.2274143"}], "href": "https://doi.org/10.1080/15384047.2023.2274143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37948132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37948132"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jing Shi, Chuanxi Yang, Jing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.122.322244"}], "href": "https://doi.org/10.1161/CIRCRESAHA.122.322244"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37955115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37955115"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xia Liu, Xinyun Liu, Chaoshi Zhuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 Promotes Malignant Progression of Lung Cancer via the NF-κB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Discov Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.24976/Discov.Med.202335179.89"}], "href": "https://doi.org/10.24976/Discov.Med.202335179.89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38058058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38058058"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yujun Shuai, Hui Zhang, Changhao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-06373-z"}], "href": "https://doi.org/10.1038/s41419-023-06373-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38182571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38182571"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiaochen Wang, Rongsong Ling, Yurong Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "4"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "C modification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oral Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41368-023-00276-7"}], "href": "https://doi.org/10.1038/s41368-023-00276-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38246918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38246918"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Qin Yan, Jing Zhou, Yang Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lactylation of NAT10 promotes N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "4"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-acetylcytidine modification on tRNA"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "Ser-CGA-1-1"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " to boost oncogenic DNA virus KSHV reactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-024-01327-0"}], "href": "https://doi.org/10.1038/s41418-024-01327-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38879723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38879723"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kang-Jing Li, Yaying Hong, Yu-Zhong Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202310131"}], "href": "https://doi.org/10.1002/advs.202310131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38922788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38922788"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Shenglei Song, Bo Li, Xinghan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 Overexpression Promotes Tumorigenesis and Epithelial-Mesenchymal Transition Through AKT Pathway in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-024-08472-z"}], "href": "https://doi.org/10.1007/s10620-024-08472-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38990269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38990269"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Mahmood Hassan Dalhat, Hisham N Altayb, Mohammad Imran Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights of human N-acetyltransferase 10 and identification of its potential novel inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-84908-0"}], "href": "https://doi.org/10.1038/s41598-021-84908-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33723305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33723305"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Nannan Zheng, Xuanqi Liu, Ying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-022-09743-z"}], "href": "https://doi.org/10.1007/s10565-022-09743-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35877022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35877022"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Qing Luo, Juxiang Zhu, Shiqian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13075-023-03250-0"}], "href": "https://doi.org/10.1186/s13075-023-03250-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38167491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38167491"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yamei Dang, Jia Li, Yuchang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.01350-23"}], "href": "https://doi.org/10.1128/jvi.01350-23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38169284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38169284"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Mahmood H Dalhat, Sharath Narayan, Hannah Serio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-024-02975-9"}], "href": "https://doi.org/10.1038/s41388-024-02975-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38409550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38409550"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Wenya Ma, Yanan Tian, Leping Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-46458-7"}], "href": "https://doi.org/10.1038/s41467-024-46458-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38459019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38459019"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Di Liu, Yu Kuang, Simin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/ard-2023-225343"}], "href": "https://doi.org/10.1136/ard-2023-225343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38724075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38724075"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mengfei Ding, Zhuoya Yu, Tiange Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-acetyltransferase 10 facilitates tumorigenesis of diffuse large B-cell lymphoma by regulating AMPK/mTOR signalling through N4-acetylcytidine modification of SLC30A9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ctm2.1747"}], "href": "https://doi.org/10.1002/ctm2.1747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38961519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38961519"}]}]}]}