{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNCAPG encodes a critical subunit of the condensin I complex that is essential for proper chromosome condensation and segregation during mitosis. Its function is tightly regulated by post‐translational modifications such as phosphorylation—an event necessary for its correct localization on chromatin and for the maintenance of genomic stability during cell division. This fundamental role in mitotic chromosome architecture lays the groundwork for its impact on cell cycle progression and overall cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA wealth of studies across diverse tumor types has demonstrated that NCAPG is often aberrantly overexpressed in cancers such as castration‐resistant prostate cancer, pediatric high‐grade gliomas, hepatocellular carcinoma, various breast cancers (including HER2+ and triple‐negative subtypes), lung cancers (non–small cell lung cancer and lung adenocarcinoma), cardia adenocarcinoma, oral squamous cell carcinoma, ovarian cancer, renal clear cell carcinoma, bladder cancer, and gastric cancer. In these contexts, high NCAPG levels contribute to aggressive clinical behavior by promoting cancer cell proliferation, migration, invasion, and by conferring resistance to therapies—all factors that correlate with poorer patient outcomes. Moreover, NCAPG expression is frequently subject to regulation by oncogenic or tumor‐suppressive microRNAs, and its dysregulation is part of complex networks driving cell cycle progression and malignant transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further indicates that NCAPG is embedded in intricate regulatory networks involving non‐coding RNAs. For instance, circular RNA isoforms (circNCAPG) and microRNAs (e.g. miR‑99a‑3p) interact with NCAPG mRNA, modulating its stability and, consequently, cancer stemness, metastatic potential, and response to treatment. Beyond oncogenesis, aberrant NCAPG expression has been linked to pathological processes in idiopathic pulmonary arterial hypertension, acute liver failure, and even autoimmune conditions such as systemic lupus erythematosus—thereby underscoring its potential as a multifaceted biomarker for prognosis and a promising therapeutic target across a spectrum of human diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lynea A Murphy, Kevin D Sarge "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.10.114"}], "href": "https://doi.org/10.1016/j.bbrc.2008.10.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18977199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18977199"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wanwei Liu, Bo Liang, Hongliang Liu, et al. 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