NCOA5 Gene

Name	nuclear receptor coactivator 5
Description	This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNuclear receptor coactivator 5 (NCOA5) is an important modulator of estrogen receptor α‐mediated transcription whose genetic variants and altered expression have been implicated in several autoimmune and inflammatory disorders. Studies have demonstrated that polymorphisms and expression changes in NCOA5 associate with increased susceptibility to rheumatoid arthritis and psoriasis, as well as with conditions like Behçet’s disease and multiple sclerosis, suggesting that NCOA5 plays a role in regulating immune-mediated processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, NCOA5 appears to have a multifaceted role. In hepatocellular carcinoma (HCC), heterozygous deletion of the Ncoa5 gene in male mice predisposes to spontaneous tumor development, accompanied by metabolic abnormalities and increased interleukin‐6 expression, suggesting a haploinsufficient tumor suppressor function. Similarly, in esophageal squamous cell carcinoma and cervical cancer, low expression of NCOA5 correlates with advanced disease parameters and poorer patient outcomes, supporting its tumor‐inhibitory roles. In contrast, elevated NCOA5 levels in luminal breast cancer are associated with aggressive tumor behavior and decreased overall survival, while in vitro loss of NCOA5 in HCC cells suppresses epithelial–mesenchymal transition and tumor cell migration, indicative of context‐dependent functions in tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in immune regulation and tumorigenesis, NCOA5 also influences metabolic homeostasis. Haploinsufficiency of NCOA5 has been linked to the development of nonalcoholic fatty liver disease, insulin resistance, and associated hepatic dysplasia, partially through the upregulation of inflammatory mediators such as IL‐6. These findings underscore the diverse functions of NCOA5 in modulating both metabolic and inflammatory pathways, thereby contributing to the pathogenesis of metabolic disorders and their complications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria I Zervou, George N Goulielmos, Francesc Castro-Giner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humimm.2011.05.014"}], "href": "https://doi.org/10.1016/j.humimm.2011.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21645569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21645569"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dina M T Koptan, Dina M Rasheed Bahgat, Asmaa A Abdelrasool, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Nuclear Receptor Coactivator 5 "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "(NCOA5)"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NCOA5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in an Egyptian Cohort with Behçet's Disease: A Single-Center Case-control Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ocul Immunol Inflamm (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09273948.2021.1889610"}], "href": "https://doi.org/10.1080/09273948.2021.1889610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34255592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34255592"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Husniye Rustemoglu, Erdem Arslan, Sema Atasever, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-023-08830-6"}], "href": "https://doi.org/10.1007/s11033-023-08830-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37817021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37817021"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shenglan Gao, Aimin Li, Feiye Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2013.11.005"}], "href": "https://doi.org/10.1016/j.ccr.2013.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24332041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24332041"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guan-qing Chen, Hui Tian, Wei-ming Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0376-y"}], "href": "https://doi.org/10.1007/s12032-014-0376-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25416054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25416054"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao-He Ye, Du-Ping Huang, Rong-Cheng Luo "}, {"type": "b", "children": [{"type": "t", "text": "NCOA5 is correlated with progression and prognosis in luminal breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.11.051"}], "href": "https://doi.org/10.1016/j.bbrc.2016.11.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27847318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27847318"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jingcai He, Wan Zhang, Aimin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.017"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29626478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29626478"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ying Liang, Tianli Zhang, Mengdie Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27911"}], "href": "https://doi.org/10.1002/jcb.27911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30335900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30335900"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yueqi Zhang, Yue Luo, Xinhui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Gastroenterol Hepatol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jcmgh.2023.09.007"}], "href": "https://doi.org/10.1016/j.jcmgh.2023.09.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37734594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37734594"}]}]}]}
Synonyms	BA465L10.6
Proteins	NCOA5_HUMAN
NCBI Gene ID	57727
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NCOA5 has 5,875 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for NCOA5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NCOA5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCOA5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCOA5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NCOA5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NCOA5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NCOA5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCOA5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCOA5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCOA5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCOA5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NCOA5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NCOA5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NCOA5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCOA5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NCOA5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NCOA5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of NCOA5 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NCOA5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NCOA5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NCOA5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NCOA5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NCOA5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NCOA5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCOA5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NCOA5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NCOA5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NCOA5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NCOA5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NCOA5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NCOA5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NCOA5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NCOA5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NCOA5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for NCOA5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NCOA5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCOA5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NCOA5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NCOA5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with NCOA5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NCOA5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NCOA5 from the GeneSigDB Published Gene Signatures dataset.