NCOA6 Gene

Name	nuclear receptor coactivator 6
Description	The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNuclear receptor coactivator 6 (NCOA6)—known also as ASC‐2, TRBP, AIB3, RAP250 or PRIP—functions as an essential transcriptional coactivator that interacts with a wide range of nuclear receptors and other transcription factors. By using its signature LXXLL motifs and additional protein interaction domains, NCOA6 assembles into multiprotein complexes that facilitate ligand‐dependent transactivation events. In these complexes, it not only bridges physical interactions with receptors including farnesoid X receptor, constitutive androstane receptor, liver X receptor, androgen receptor and heat shock factor 1 but also helps to coordinate chromatin modifications such as histone H3 lysine 4 methylation and DNA‐PK–mediated phosphorylation that ultimately promote target gene activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNCOA6 is also pivotal in mediating the synergistic regulation of metabolic gene expression. For instance, it bridges interactions between hepatocyte nuclear factor 4α and the constitutive androstane receptor to co‐activate detoxification enzymes such as CYP2C9. In estrogen receptor–mediated transcription—exemplified by GREB1 gene activation—NCOA6 promotes enhancer–promoter looping and recruits key histone‐modifying enzymes, thereby establishing an epigenetic environment favorable for robust gene induction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in transcriptional regulation, NCOA6 is indispensable for various developmental and tissue‐specific processes. Alternative splicing generates isoforms with distinct subcellular localizations, which may underlie its diverse functions in different cellular contexts. NCOA6 activity is vital for pancreatic β‐cell function, placental development, and the decidualization of endometrial stromal cells; moreover, mutations in NCOA6 have been implicated in congenital cataracts, and in breast tumor cells its regulation of genes such as FOS contributes to cell invasion and migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, aberrant NCOA6 expression is associated with oncogenesis and inflammatory responses. Overexpression in hepatocellular carcinoma correlates with increased proliferation, migration and poor clinical prognosis, whereas in immune cells NCOA6 is recruited from the nucleus to the cytoplasm where it participates in the assembly and activation of the NLRP3 inflammasome, thereby modulating proinflammatory cytokine production. Such multifaceted roles underscore NCOA6 as a key integrator of nuclear receptor signaling, developmental programming and immune regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Young-Hwa Goo, Young Chang Sohn, Dae-Hwan Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.1.140-149.2003"}], "href": "https://doi.org/10.1128/MCB.23.1.140-149.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482968"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lan Ko, William W Chin "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209723200"}], "href": "https://doi.org/10.1074/jbc.M209723200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12519782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12519782"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seung-Whan Kim, Keunhee Park, Eunyee Kwak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.10.3583-3592.2003"}], "href": "https://doi.org/10.1128/MCB.23.10.3583-3592.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12724417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12724417"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Young-Hwa Goo, Soon-Young Na, Hao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312563200"}], "href": "https://doi.org/10.1074/jbc.M312563200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14645241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14645241"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "SunHwa Hong, Hyun Mi Choi, Min Jung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311752200"}], "href": "https://doi.org/10.1074/jbc.M311752200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14734562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14734562"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "SunHwa Hong, Sun Hee Kim, Mi Ae Heo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0014-5793(04)00028-6"}], "href": "https://doi.org/10.1016/S0014-5793(04"}, {"type": "t", "text": "00028-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14960326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14960326"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eunho Choi, Seunghee Lee, Seon-Yong Yeom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0066"}], "href": "https://doi.org/10.1210/me.2005-0066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15764585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15764585"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "You Lee Son, Ok Gu Park, Gwang Sik Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20070837"}], "href": "https://doi.org/10.1042/BJ20070837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18031289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18031289"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Per Antonson, Tomas Jakobsson, Tova Almlöf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M707203200"}], "href": "https://doi.org/10.1074/jbc.M707203200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18263591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18263591"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sailesh Surapureddi, Ritu Rana, Janardan K Reddy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.108.048983"}], "href": "https://doi.org/10.1124/mol.108.048983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18552123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18552123"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dae-Hwan Kim, Jeongkyung Lee, Bora Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0099"}], "href": "https://doi.org/10.1210/me.2009-0099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19556342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19556342"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sailesh Surapureddi, Ritu Rana, Joyce A Goldstein "}, {"type": "b", "children": [{"type": "t", "text": "NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2011.01.013"}], "href": "https://doi.org/10.1016/j.phrs.2011.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21292004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21292004"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhangwei Tong, Yonghong Liu, Xiaobin Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer-promoter interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.010704"}], "href": "https://doi.org/10.1074/jbc.RA119.010704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31744881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31744881"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hans Burghardt, Abel López-Bermejo, Bernhard Baumgartner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Endocrinol (Oxf) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2265.2008.03232.x"}], "href": "https://doi.org/10.1111/j.1365-2265.2008.03232.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18462265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18462265"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yiwei Tony Zhu, Liping Hu, Chao Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M900935200"}], "href": "https://doi.org/10.1074/jbc.M900935200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19329434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19329434"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qingtian Li, Jianming Xu "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.7.505"}], "href": "https://doi.org/10.7150/ijbs.7.505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21552418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21552418"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Liang Wu, Kun-Qing Zhao, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor coactivator 6 promotes HTR-8/SVneo cell invasion and migration by activating NF-κB-mediated MMP9 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12876"}], "href": "https://doi.org/10.1111/cpr.12876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32790097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32790097"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Dinesh Kumar Kandaswamy, Makarla Venkata Sathya Prakash, Jochen Graw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Application of WES Towards Molecular Investigation of Congenital Cataracts: Identification of Novel Alleles and Genes in a Hospital-Based Cohort of South India."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21249569"}], "href": "https://doi.org/10.3390/ijms21249569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33339270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33339270"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Norikazu Watanabe, Jun Kawagoe, Akiko Sugiyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor coactivator-6 is essential for the morphological change of human uterine stromal cell decidualization via regulating actin fiber reorganization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.23568"}], "href": "https://doi.org/10.1002/mrd.23568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35384116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35384116"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yinghao Fang, Yuyan Xu, Wei Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15577"}], "href": "https://doi.org/10.1111/cas.15577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36086920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36086920"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kang-Gu Lee, Bong-Ki Hong, Saseong Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41423-023-01121-x"}], "href": "https://doi.org/10.1038/s41423-023-01121-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38195836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38195836"}]}]}]}
Synonyms	NRC, RAP250, ASC2
Proteins	NCOA6_HUMAN
NCBI Gene ID	23054
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NCOA6 has 6,750 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for NCOA6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NCOA6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCOA6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NCOA6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NCOA6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NCOA6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCOA6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NCOA6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCOA6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCOA6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NCOA6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCOA6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NCOA6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NCOA6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NCOA6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCOA6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NCOA6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NCOA6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NCOA6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NCOA6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NCOA6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NCOA6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NCOA6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NCOA6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NCOA6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NCOA6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NCOA6 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCOA6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NCOA6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NCOA6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NCOA6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NCOA6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NCOA6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NCOA6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NCOA6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NCOA6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NCOA6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NCOA6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NCOA6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NCOA6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCOA6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NCOA6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.