{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNCOR2 (also known as SMRT) is a pivotal nuclear corepressor that regulates transcription through chromatin‐modifying complexes. Structural and biochemical studies have demonstrated that the deacetylase activation domain of NCOR2 undergoes dramatic conformational rearrangement when binding HDAC3—a process stabilized by an essential inositol tetraphosphate that functions as intermolecular “glue” (e.g."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, NCOR2 interacts directly with various nuclear receptors and transcription factors—including retinoic acid receptors, androgen receptors, and the BCL6 BTB domain—via defined motifs such as the extended SANT domains and conserved repression regions, thereby facilitating histone deacetylation and gene silencing in the absence of ligand (e.g."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn multiple cancer settings, NCOR2 plays a complex role in modulating hormone‐dependent as well as other oncogenic signaling pathways. In prostate cancer cells, for example, aberrantly elevated NCOR2 expression suppresses the induction of antiproliferative genes by nuclear receptors, and in androgen receptor– and estrogen receptor–mediated pathways NCOR2 competes with coactivators to fine‐tune transcriptional responsiveness to ligands—including effects observed with tamoxifen and other antagonists (e.g."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "20"}]}, {"type": "t", "text": " Moreover, NCOR2’s recruitment in corepressor complexes extends to additional oncogenic contexts. For instance, in breast cancer, a novel splice variant of NCOR2 (BQ323636.1) has been linked to tamoxifen resistance, and in lung adenocarcinoma its downregulation (often mediated by factors such as HP1γ) correlates with the up‐regulation of protumorigenic genes. In adipocytes and other metabolic tissues, reduced NCOR2 levels are associated with elevated inflammatory transcription, underlining its broad role as a transcriptional brake (e.g."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in chromatin remodeling and nuclear receptor signaling, NCOR2 contributes to cell differentiation and can be subject to oncogenic rearrangements. In immune cells, NCOR2 is implicated in governing the differentiation of monocytes into dendritic cells, indicating its importance in modulating inflammatory responses. Notably, in rare soft tissue tumors, recurrent HMGA2–NCOR2 gene fusions have been identified, suggesting that alterations in NCOR2 structure and function can drive neoplastic transformation. These diverse functions are further underscored by studies showing that in colon and other cells, NCOR2 is dynamically recruited—even alongside coactivators—to fine‐tune gene expression programs critical for cellular homeostasis (e.g."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuo Dong, David J Tweardy "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.8.2637"}], "href": "https://doi.org/10.1182/blood.v99.8.2637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11929748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11929748"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jagadish C Ghosh, Xiaofang Yang, Aihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions that determine the assembly of a retinoid X receptor/corepressor complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.092043399"}], "href": "https://doi.org/10.1073/pnas.092043399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11972046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11972046"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "S Renée Rushing, Michael S Denison "}, {"type": "b", "children": [{"type": "t", "text": "The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0003-9861(02)00233-3"}], "href": "https://doi.org/10.1016/s0003-9861(02"}, {"type": "t", "text": "00233-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12139968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12139968"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guoqing Liao, Liuh-Yow Chen, Aihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206374200"}], "href": "https://doi.org/10.1074/jbc.M206374200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12441355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12441355"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Herborg Hauksdottir, Behnom Farboud, Martin L Privalsky "}, {"type": "b", "children": [{"type": "t", "text": "Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2002-0340"}], "href": "https://doi.org/10.1210/me.2002-0340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12554770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12554770"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Irina U Agoulnik, William C Krause, William E Bingman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repressors of androgen and progesterone receptor action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305153200"}], "href": "https://doi.org/10.1074/jbc.M305153200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12771131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12771131"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jiujiu Yu, Yun Li, Takahiro Ishizuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg326"}], "href": "https://doi.org/10.1093/emboj/cdg326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12840002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12840002"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "K Farid Ahmad, Ari Melnick, Stuart Lax, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00454-4"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00454-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14690607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14690607"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fergal J Fleming, Arnold D K Hill, Enda W McDermott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2003-031048"}], "href": "https://doi.org/10.1210/jc.2003-031048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14715875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14715875"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Peter J Watson, Louise Fairall, Guilherme M Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of HDAC3 bound to co-repressor and inositol tetraphosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10728"}], "href": "https://doi.org/10.1038/nature10728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22230954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22230954"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Farhat L Khanim, Lyndon M Gommersall, Victoria H J Wood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207772"}], "href": "https://doi.org/10.1038/sj.onc.1207772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15300237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15300237"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Erika Krasnickas Keeton, Myles Brown "}, {"type": "b", "children": [{"type": "t", "text": "Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2004-0395"}], "href": "https://doi.org/10.1210/me.2004-0395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15802375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15802375"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ho-Geun Yoon, Jiemin Wong "}, {"type": "b", "children": [{"type": "t", "text": "The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0324"}], "href": "https://doi.org/10.1210/me.2005-0324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16373395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16373395"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sandrine Jayne, Carin G M Zwartjes, Frederik M A van Schaik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20060406"}], "href": "https://doi.org/10.1042/BJ20060406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16712523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16712523"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Andrew R Green, Claire Burney, Christopher J Granger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-007-9737-y"}], "href": "https://doi.org/10.1007/s10549-007-9737-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17902051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17902051"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kristopher J Stanya, Yu Liu, Anthony R Means, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200806172"}], "href": "https://doi.org/10.1083/jcb.200806172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18838553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18838553"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Christopher A Haiman, Rachel R Garcia, Chris Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-9-43"}], "href": "https://doi.org/10.1186/1471-2407-9-43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19183483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19183483"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Pushpankur Ghoshal, Alain J Nganga, Joseph Moran-Giuati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-3467"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-3467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19417136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19417136"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Vishal Lamba, John C Panetta, Stephen Strom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic predictors of interindividual variability in hepatic CYP3A4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.109.160804"}], "href": "https://doi.org/10.1124/jpet.109.160804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19934400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19934400"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jasmeen Oberoi, Louise Fairall, Peter J Watson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1983"}], "href": "https://doi.org/10.1038/nsmb.1983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21240272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21240272"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Alejandro S Godoy, Paula C Sotomayor, Marcelo Villagran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.06.005"}], "href": "https://doi.org/10.1016/j.bbrc.2012.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22695118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22695118"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Mark B Meyer, J Wesley Pike "}, {"type": "b", "children": [{"type": "t", "text": "Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2012.08.006"}], "href": "https://doi.org/10.1016/j.jsbmb.2012.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22944139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22944139"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Luduo Zhang, Chun Gong, Samantha L Y Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-2241"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-2241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23117886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23117886"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Amine Toubal, Karine Clément, Rongrong Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI64052"}], "href": "https://doi.org/10.1172/JCI64052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23221346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23221346"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jennifer R Kulzer, Michael L Stitzel, Mario A Morken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.12.011"}], "href": "https://doi.org/10.1016/j.ajhg.2013.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24439111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24439111"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Gregg M Hudson, Peter J Watson, Louise Fairall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.661058"}], "href": "https://doi.org/10.1074/jbc.M115.661058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26055705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26055705"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jil Sander, Susanne V Schmidt, Branko Cirovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2017.11.024"}], "href": "https://doi.org/10.1016/j.immuni.2017.11.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29262348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29262348"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hunain Alam, Na Li, Shilpa S Dhar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-3571"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-3571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29764865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29764865"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Abbas Agaimy, Michael Michal, Robert Stoehr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-021-00789-8"}], "href": "https://doi.org/10.1038/s41379-021-00789-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33742141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33742141"}]}]}]}