{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNKp44, encoded by the NCR2 gene, is an activating receptor with a unique structural organization that distinguishes it from other immunoglobulin‐like molecules. Detailed structural analyses have shown that its extracellular Ig‐like domain forms a distinctive dimeric “saddle‐shaped” arrangement and that its surface expression relies on noncovalent association with the signaling adaptor DAP12 rather than on intrinsic inhibitory motifs. Moreover, alternative splicing of NCR2 gives rise to distinct NKp44 isoforms that may have different functional outcomes, underscoring the importance of this receptor in tailoring immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA wide array of studies has demonstrated that NKp44 plays multifaceted roles in immune surveillance against pathogens and tumors. In the context of infection, NKp44 directly recognizes viral envelope proteins—including those from influenza viruses and various flaviviruses—as well as components of other pathogens, thereby triggering NK cell degranulation and cytokine production. In parallel, NKp44 expressed on natural killer as well as innate lymphoid cell subsets contributes to tissue homeostasis and inflammatory disorders; for example, shifts in NKp44⁺ ILC3 frequencies and cytokine‐secretion profiles have been linked to psoriasis and altered immune responses in settings as diverse as hepatitis E infection and xenotransplantation. Moreover, NKp44 engagement by tumor ligands—such as a cell‐surface isoform of proliferating cell nuclear antigen (PCNA) or an alternatively spliced isoform of MLL5 (NKp44L)—can either stimulate cytotoxicity against cancer cells or, paradoxically, result in inhibitory signals, NK cell apoptosis, or even immune evasion by tumors. These findings collectively illustrate that NKp44 interactions—with ligands expressed on transformed cells, virally infected targets, or even normal stromal and chondrocyte cells—are central to modulating NK cell effector functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its well‐documented roles in target cell recognition, emerging evidence highlights the regulatory versatility of NKp44 through differential splicing and context‐dependent ligand engagement. Distinct splice variants of NCR2 have been associated with divergent prognostic outcomes in acute myeloid leukemia and other malignancies, while tissue‐specific expression patterns—in placental and decidual cells or even on subsets of CD8⁺ T cells—suggest that NKp44 may sculpt adaptive immune responses, limit hyper-expansion of effector clones, and modulate cytokine‐driven inflammation. Furthermore, therapeutic strategies aimed at disrupting or harnessing NKp44–ligand interactions (for instance, using NKp44‐derived peptides that block inhibitory binding to PCNA) underscore the receptor’s promising potential as both a biomarker and a target in immunomodulatory interventions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Claudia Cantoni, Marco Ponassi, Roberto Biassoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr D Biol Crystallogr (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/s0907444902012325"}], "href": "https://doi.org/10.1107/s0907444902012325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12351833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12351833"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Richard J N Allcock, Alexander D Barrow, Simon Forbes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/immu.200310033"}], "href": "https://doi.org/10.1002/immu.200310033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12645956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12645956"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Raffaella Augugliaro, Silvia Parolini, Roberta Castriconi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200323896"}], "href": "https://doi.org/10.1002/eji.200323896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12731048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12731048"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Claudia Cantoni, Marco Ponassi, Roberto Biassoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0969-2126(03)00095-9"}], "href": "https://doi.org/10.1016/s0969-2126(03"}, {"type": "t", "text": "00095-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12791260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12791260"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kerry S Campbell, Sei-ichi Yusa, Akiko Kikuchi-Maki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.2.899"}], "href": "https://doi.org/10.4049/jimmunol.172.2.899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14707061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14707061"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pegah Nowbakht, Mihai-Constantin S Ionescu, Andreas Rohner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-07-2585"}], "href": "https://doi.org/10.1182/blood-2004-07-2585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15657183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15657183"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alessandro Poggi, Anna-Maria Massaro, Simone Negrini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.5.2653"}], "href": "https://doi.org/10.4049/jimmunol.174.5.2653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15728472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15728472"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anja Fuchs, Marina Cella, Takayuki Kondo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-12-4802"}], "href": "https://doi.org/10.1182/blood-2004-12-4802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15941912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15941912"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Pietro Forte, Benjamin G Lilienfeld, Bettina C Baumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.175.8.5463"}], "href": "https://doi.org/10.4049/jimmunol.175.8.5463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16210654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16210654"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Oren Hershkovitz, Sergey Jivov, Noga Bloushtain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi7000455"}], "href": "https://doi.org/10.1021/bi7000455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17536787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17536787"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Joanna W Ho, Oren Hershkovitz, Malik Peiris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02065-07"}], "href": "https://doi.org/10.1128/JVI.02065-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18077718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18077718"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andreina Byrd, Sabrina C Hoffmann, Mostafa Jarahian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0001339"}], "href": "https://doi.org/10.1371/journal.pone.0001339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18092004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18092004"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Oren Hershkovitz, Benyamin Rosental, Lior Ann Rosenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0802806"}], "href": "https://doi.org/10.4049/jimmunol.0802806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19635919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19635919"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Tetsuro Takayama, Nobuhiko Kamada, Hiroshi Chinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.05.040"}], "href": "https://doi.org/10.1053/j.gastro.2010.05.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20638936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20638936"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Irene Bonaccorsi, Claudia Cantoni, Paolo Carrega, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0015080"}], "href": "https://doi.org/10.1371/journal.pone.0015080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21151495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21151495"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Benyamin Rosental, Michael Brusilovsky, Uzi Hadad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102267"}], "href": "https://doi.org/10.4049/jimmunol.1102267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22021614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22021614"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Régis T Costello, Benjamin Knoblauch, Carole Sanchez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of natural killer cell activating receptors in patients with chronic lymphocytic leukaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2567.2011.03521.x"}], "href": "https://doi.org/10.1111/j.1365-2567.2011.03521.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22044312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22044312"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alexis Spain Madrid, Don Ganem "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00252-12"}], "href": "https://doi.org/10.1128/JVI.00252-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22674989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22674989"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Rossana Tallerico, Matilde Todaro, Simone Di Franco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1201542"}], "href": "https://doi.org/10.4049/jimmunol.1201542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23345327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23345327"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nathan C Horton, Stephen O Mathew, Porunelloor A Mathew "}, {"type": "b", "children": [{"type": "t", "text": "Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0059552"}], "href": "https://doi.org/10.1371/journal.pone.0059552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23527218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23527218"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "S Esin, C Counoupas, A Aulicino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of Mycobacterium tuberculosis cell wall components with the human natural killer cell receptors NKp44 and Toll-like receptor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/sji.12052"}], "href": "https://doi.org/10.1111/sji.12052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23578092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23578092"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Timor Glatzer, Monica Killig, Johannes Meisig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2013.05.013"}], "href": "https://doi.org/10.1016/j.immuni.2013.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23791642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23791642"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Florence Baychelier, Alexis Sennepin, Myriam Ermonval, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-03-489054"}], "href": "https://doi.org/10.1182/blood-2013-03-489054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23958951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23958951"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Agata Białoszewska, Florence Baychelier, Justyna Niderla-Bielińska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2013.08.005"}], "href": "https://doi.org/10.1016/j.cellimm.2013.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24044960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24044960"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "A Sheikhi, K Saadati, A Jafarzadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Augmenting the expression of NKp44 molecule and the natural killer activity in peripheral blood mononuclear cells from patients with malignant colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Res (Stuttg) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0033-1358465"}], "href": "https://doi.org/10.1055/s-0033-1358465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24154937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24154937"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Federica Villanova, Barry Flutter, Isabella Tosi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2013.477"}], "href": "https://doi.org/10.1038/jid.2013.477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24352038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24352038"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Marcel B M Teunissen, J Marius Munneke, Jochem H Bernink, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2014.146"}], "href": "https://doi.org/10.1038/jid.2014.146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24658504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24658504"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Natasja Nielsen, Veronique Pascal, Andreas E R Fasth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/imm.12271"}], "href": "https://doi.org/10.1111/imm.12271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24673109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24673109"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Rumki Das, Anuradha Tripathy "}, {"type": "b", "children": [{"type": "t", "text": "Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Microbiol Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00430-014-0338-1"}], "href": "https://doi.org/10.1007/s00430-014-0338-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24824867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24824867"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Samantha McQuaid, Sinead Loughran, Patrick Power, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haemagglutinin-neuraminidase from HPIV3 mediates human NK regulation of T cell proliferation via NKp44 and NKp46."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/jgv.0.001070"}], "href": "https://doi.org/10.1099/jgv.0.001070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29683419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29683419"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Monica Parodi, Herman Favoreel, Giovanni Candiano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.00719"}], "href": "https://doi.org/10.3389/fimmu.2019.00719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31024551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31024551"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alexander David Barrow, Claudia Jane Martin, Marco Colonna "}, {"type": "b", "children": [{"type": "t", "text": "The Natural Cytotoxicity Receptors in Health and Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.00909"}], "href": "https://doi.org/10.3389/fimmu.2019.00909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31134055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31134055"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Avishai Shemesh, Michael Brusilovsky, Uzi Hadad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Survival in acute myeloid leukemia is associated with NKp44 splice variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8782"}], "href": "https://doi.org/10.18632/oncotarget.8782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27102296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27102296"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Avishai Shemesh, Aleksandra Kugel, Naama Steiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12292"}], "href": "https://doi.org/10.18632/oncotarget.12292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27765926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27765926"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Enas Said Essa, Gehan Abd-Elfatah Tawfeek, Suzan Ahmed El Hassanin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation the expression of natural killer cell activating receptor (NKp44) in the peripheral blood of diffuse large B-cell lymphoma patients and the correlation with clinic pathological features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clim.2017.12.003"}], "href": "https://doi.org/10.1016/j.clim.2017.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29247708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29247708"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Kelly E Bowen, Stephen O Mathew, Kathleen Borgmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0193008"}], "href": "https://doi.org/10.1371/journal.pone.0193008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29447242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29447242"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Avishai Shemesh, Kiran Kundu, Refael Peleg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.01114"}], "href": "https://doi.org/10.3389/fimmu.2018.01114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29875773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29875773"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "S L McQuaid, S T Loughran, P A Power, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low-dose IL-2 induces CD56"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "bright"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " NK regulation of T cells via NKp44 and NKp46."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cei.13422"}], "href": "https://doi.org/10.1111/cei.13422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31989589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31989589"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Benedetta Padoan, Christian Casar, Jenny Krause, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2024.114089"}], "href": "https://doi.org/10.1016/j.celrep.2024.114089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38615318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38615318"}]}]}]}