{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNDRG1 is a multifunctional protein whose activity is tightly controlled by post‐translational modifications and cellular stress signals. In skeletal muscle and various tissues, for example, SGK1 rapidly phosphorylates NDRG1 at specific threonine and serine residues; this priming event enables subsequent phosphorylation by GSK3, thereby potentially modulating its downstream functions. In addition, cellular iron depletion—whether induced by iron chelators or hypoxic conditions—stimulates NDRG1 transcription via HIF‐1α–dependent and –independent mechanisms, and elements such as Egr‐1 bind its promoter to further enhance expression. NDRG1 is typically highly expressed in differentiated epithelial cells and appears to contribute to cellular protective responses against ischemic and oxidative stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, NDRG1 acts as a metastasis suppressor by modulating key signaling pathways that govern epithelial–mesenchymal transition, cell adhesion, and motility. It promotes the retention of E‐cadherin and β‐catenin at the plasma membrane, thereby inhibiting EMT and reducing tumor cell migration, invasion, and metastatic spread. Its expression is enhanced by p53 activation and iron chelation, linking stress and DNA damage responses to the induction of apoptosis and suppression of oncogenic signaling cascades—including those mediated by NF‐κB, Src, and growth factor receptors. Clinical studies consistently show that high NDRG1 levels correlate with lower tumor grade and reduced metastasis across several malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these roles, NDRG1 integrates into broader cellular regulatory networks that influence vesicular trafficking, autophagy, and cytoskeletal organization. It has been implicated in the recycling of adhesion molecules through interactions with endosomal proteins and Rab4a, and it modulates signaling routes such as ROCK1/MLC2 and EGFR/HER pathways to affect actin dynamics and cell motility. 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"}, {"type": "b", "children": [{"type": "t", "text": "Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.10089"}], "href": "https://doi.org/10.1002/ana.10089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11835375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11835375"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pascale Lachat, Philip Shaw, Sandra Gebhard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of NDRG1, a differentiation-related gene, in human tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-002-0460-9"}], "href": "https://doi.org/10.1007/s00418-002-0460-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12432451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12432451"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Baosheng Chen, D Michael Nelson, Yoel Sadovsky "}, {"type": "b", "children": [{"type": "t", "text": "N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507330200"}], "href": "https://doi.org/10.1074/jbc.M507330200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314423"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ping Zhang, Kam-Meng Tchou-Wong, Max Costa "}, {"type": "b", "children": [{"type": "t", "text": "Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1525"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17909017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17909017"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qiang Wang, Li-Hong Li, Guo-Dong Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-2448-4"}], "href": "https://doi.org/10.1007/s11033-012-2448-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23526365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23526365"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zaklina Kovacevic, Des R Richardson "}, {"type": "b", "children": [{"type": "t", "text": "The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgl146"}], "href": "https://doi.org/10.1093/carcin/bgl146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16920733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16920733"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Susanne Stein, Emily K Thomas, Birger Herzog, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NDRG1 is necessary for p53-dependent apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M400386200"}], "href": "https://doi.org/10.1074/jbc.M400386200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15377670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15377670"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zaklina Kovacevic, Sherin Chikhani, Goldie Y L Lui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxid Redox Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/ars.2011.4273"}], "href": "https://doi.org/10.1089/ars.2011.4273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22462691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22462691"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Markus Weiler, Jonas Blaes, Stefan Pusch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1314469111"}], "href": "https://doi.org/10.1073/pnas.1314469111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24367102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24367102"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jing Sun, Daohai Zhang, Dong-Hun Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgt163"}], "href": "https://doi.org/10.1093/carcin/bgt163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23671130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23671130"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jun Cheng, Hai-Yang Xie, Xiao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2011.06.001"}], "href": "https://doi.org/10.1016/j.canlet.2011.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21763068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21763068"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sushant K Kachhap, Dennis Faith, David Z Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0000844"}], "href": "https://doi.org/10.1371/journal.pone.0000844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17786215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17786215"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dorothee Pflueger, David S Rickman, Andrea Sboner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.09572"}], "href": "https://doi.org/10.1593/neo.09572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19649210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19649210"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Runsen Jin, Wensheng Liu, Sharleen Menezes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.147835"}], "href": "https://doi.org/10.1242/jcs.147835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24829151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24829151"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Fumihito Hosoi, Hiroto Izumi, Akihiko Kawahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-4882"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-4882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19491262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19491262"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Maria Aparecida Nagai, Renê Gerhard, José Humberto T G Fregnani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-010-0867-2"}], "href": "https://doi.org/10.1007/s10549-010-0867-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20369286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20369286"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jing Sun, Daohai Zhang, Ying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.112.083097"}], "href": "https://doi.org/10.1124/mol.112.083097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23188716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23188716"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wensheng Liu, Fei Yue, Minhua Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3316"}], "href": "https://doi.org/10.18632/oncotarget.3316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25860930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25860930"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Zaklina Kovacevic, Sharleen V Menezes, Sumit Sahni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.689653"}], "href": "https://doi.org/10.1074/jbc.M115.689653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26534963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26534963"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "K L Redmond, N T Crawford, H Farmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.84"}], "href": "https://doi.org/10.1038/onc.2010.84"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20348948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20348948"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Barbara Strzelczyk, Aneta Szulc, Robert Rzepko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Surg Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1245/s10434-009-0381-0"}], "href": "https://doi.org/10.1245/s10434-009-0381-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19259744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19259744"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ranlu Liu, Jing Li, Zhigang Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0068982"}], "href": "https://doi.org/10.1371/journal.pone.0068982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23874837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23874837"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "E Angst, S Sibold, C Tiffon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603256"}], "href": "https://doi.org/10.1038/sj.bjc.6603256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16832411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16832411"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Sharleen V Menezes, Leyla Fouani, Michael L H Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metastasis suppressor, NDRG1, attenuates oncogenic TGF-β and NF-κB signaling to enhance membrane E-cadherin expression in pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgy178"}], "href": "https://doi.org/10.1093/carcin/bgy178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30561520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30561520"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jason R Hickok, Sumit Sahni, Yuliya Mikhed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.287052"}], "href": "https://doi.org/10.1074/jbc.M111.287052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21976667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21976667"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Kyung-Tae Kim, Pat P Ongusaha, Young-Kwon Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M400781200"}], "href": "https://doi.org/10.1074/jbc.M400781200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15247272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15247272"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "YooHyun Song, Yoshinao Oda, Mikifumi Hori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2009.07.011"}], "href": "https://doi.org/10.1016/j.humpath.2009.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19800102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19800102"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Boqian Sun, Dake Chu, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of NDRG1 in glioma is related to tumor progression and survival of patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-009-9859-7"}], "href": "https://doi.org/10.1007/s11060-009-9859-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19337694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19337694"}]}]}]}