{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNEDD9 (also known as HEF1 or Cas‐L) is a multi‐domain docking/scaffolding protein that integrates signals from growth factor receptors, integrins, and other adhesion molecules to regulate fundamental aspects of cell behavior. In “normal” cells such as fibroblasts and neuroblastoma cells, NEDD9 expression is induced by cytokines and morphogens including transforming growth factor‐β₁ and all‐trans retinoic acid, which in turn promotes cytoskeletal reorganization, neurite‐like process formation, cell spreading, and cell cycle progression. NEDD9 mediates key nonmitotic events such as ciliary disassembly via its interaction with Aurora A kinase and HDAC6, and it coordinates the activation cycle of RhoA during mitosis via binding to exchange factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of tumorigenesis, aberrantly elevated NEDD9 plays a pivotal role in driving invasion, migration, and metastatic progression in a wide spectrum of cancers—including melanoma, colorectal, lung, breast, prostate, cervical, pancreatic, gastric, ovarian, and hepatocellular carcinoma. Upregulation of NEDD9 in these cancers correlates with increased invadopodia formation, extracellular matrix remodeling (via regulation of matrix metalloproteinases and glycosaminoglycan synthesis), disruption of epithelial–mesenchymal homeostasis, and altered integrin and receptor tyrosine kinase signaling. In several instances, microRNAs (for example, miR‐145 and miR‐363‐3p) directly target NEDD9, further modulating these pro‐metastatic phenotypes and underscoring its prognostic value and potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its contributions to epithelial tumor progression, NEDD9 is also implicated in immune regulation and aspects of neural development. In T cells, for example, Abl family kinases phosphorylate NEDD9 to promote chemokine-induced polarization and migration, while in the context of viral oncogenesis, NEDD9 interacts with HTLV-I Tax to modulate NF-κB signaling. Genetic variants in NEDD9 have additionally been linked to neurodegenerative processes, reflecting its broader role during development and in disease states beyond solid tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "38", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingzhe Zheng, Paula J McKeown-Longo "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202263200"}], "href": "https://doi.org/10.1074/jbc.M202263200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12189134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12189134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ronald A Merrill, Angela Wai-Man See, Margaret L Wertheim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20159"}], "href": "https://doi.org/10.1002/dvdy.20159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15376324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15376324"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elena N Pugacheva, Erica A Golemis "}, {"type": "b", "children": [{"type": "t", "text": "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1309"}], "href": "https://doi.org/10.1038/ncb1309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16184168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16184168"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sharmilla D Bargon, Peter W Gunning, Geraldine M O'Neill "}, {"type": "b", "children": [{"type": "t", "text": "The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2005.10.008"}], "href": "https://doi.org/10.1016/j.bbamcr.2005.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16344118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16344118"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Disha Dadke, Michael Jarnik, Elena N Pugacheva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e05-03-0237"}], "href": "https://doi.org/10.1091/mbc.e05-03-0237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16394104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16394104"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Elena N Pugacheva, Sandra A Jablonski, Tiffiney R Hartman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HEF1-dependent Aurora A activation induces disassembly of the primary cilium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.04.035"}], "href": "https://doi.org/10.1016/j.cell.2007.04.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17604723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17604723"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julien Chapuis, Frédéric Moisan, Georges Mellick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn183"}], "href": "https://doi.org/10.1093/hmg/ddn183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18579580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18579580"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "D C Knutson, M Clagett-Dame "}, {"type": "b", "children": [{"type": "t", "text": "atRA Regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2008.06.005"}], "href": "https://doi.org/10.1016/j.abb.2008.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18585997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18585997"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Geoffroy Laumet, Vincent Chouraki, Benjamin Grenier-Boley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2010-100126"}], "href": "https://doi.org/10.3233/JAD-2010-100126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20413850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20413850"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mahendra Singh, Lauren Cowell, Sachiko Seo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-007-0036-3"}], "href": "https://doi.org/10.1007/s12013-007-0036-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17703068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17703068"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Geraldine M O'Neill, Sachiko Seo, Ilya G Serebriiskii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1328"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17908996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17908996"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "J T Lucas, B P Salimath, M G Slomiany, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.185"}], "href": "https://doi.org/10.1038/onc.2010.185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20498643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20498643"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Y Li, J H Bavarva, Z Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.632"}], "href": "https://doi.org/10.1038/onc.2010.632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21317929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21317929"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nadezhda Tikhmyanova, Erica A Golemis "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0022102"}], "href": "https://doi.org/10.1371/journal.pone.0022102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21765937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21765937"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jessica Ahn, Victoria Sanz-Moreno, Christopher J Marshall "}, {"type": "b", "children": [{"type": "t", "text": "The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.101444"}], "href": "https://doi.org/10.1242/jcs.101444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22328516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22328516"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jing-Xia Chang, Feng Gao, Guo-Qiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and clinical significance of NEDD9 in lung tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0213-0"}], "href": "https://doi.org/10.1007/s12032-012-0213-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22447485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22447485"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Maria Carmela Speranza, Véronique Frattini, Federica Pisati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.547"}], "href": "https://doi.org/10.18632/oncotarget.547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22869051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22869051"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shunsuke Kondo, Satoshi Iwata, Taketo Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-11-2162"}], "href": "https://doi.org/10.1158/1078-0432.CCR-11-2162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23037767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23037767"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yan Feng, Ye Wang, Zuoyun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-1909"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-1909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23074285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23074285"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wei Guo, Dong Ren, Xiuting Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24502"}], "href": "https://doi.org/10.1002/jcb.24502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23355420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23355420"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ni Sima, Xiaodong Cheng, Feng Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0074594"}], "href": "https://doi.org/10.1371/journal.pone.0074594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24058594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24058594"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yujuan Jin, Fei Li, Chao Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28568"}], "href": "https://doi.org/10.1002/ijc.28568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24174333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24174333"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Haixia Wang, Xiaoling Mu, Suiyang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 overexpression is associated with the progression of and an unfavorable prognosis in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2013.10.005"}], "href": "https://doi.org/10.1016/j.humpath.2013.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24439227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24439227"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Rongfeng Shi, Lei Wang, Tao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0852-4"}], "href": "https://doi.org/10.1007/s12032-014-0852-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24469954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24469954"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Varvara K Kozyreva, Sarah L McLaughlin, Ryan H Livengood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0654"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24574519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24574519"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kazuya Morimoto, Tomoaki Tanaka, Yujiro Nitta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: involvement in cancer progressiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.22809"}], "href": "https://doi.org/10.1002/pros.22809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24728978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24728978"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Peng Li, Houmin Zhou, Xinhong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24966970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24966970"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Y V Loskutov, P Y Kozyulina, V K Kozyreva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.297"}], "href": "https://doi.org/10.1038/onc.2014.297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25241893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25241893"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Joji Iida, Jesse Dorchak, Rebecca Clancy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2014.11.002"}], "href": "https://doi.org/10.1016/j.yexcr.2014.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25445787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25445787"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Tong Han, Xiao-Ping Yi, Bo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-145 suppresses cell proliferation, invasion and migration in pancreatic cancer cells by targeting NEDD9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3294"}], "href": "https://doi.org/10.3892/mmr.2015.3294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25646678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25646678"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Elena Shagisultanova, Anna V Gaponova, Rashid Gabbasov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2015.04.086"}], "href": "https://doi.org/10.1016/j.gene.2015.04.086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25967390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25967390"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Rashid Gabbasov, Fang Xiao, Caitlin G Howe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0296-y"}], "href": "https://doi.org/10.1038/s41388-018-0296-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29773902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29773902"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Simon Haworth, Dmitry Shungin, Justin T van der Tas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Consortium-based genome-wide meta-analysis for childhood dental caries traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy237"}], "href": "https://doi.org/10.1093/hmg/ddy237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29931343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29931343"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Weiwei Yu, Jie Ding, Maio He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0463-1"}], "href": "https://doi.org/10.1038/s41388-018-0463-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30250297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30250297"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jingxia Chang, Feng Gao, Heying Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29099"}], "href": "https://doi.org/10.1002/jcp.29099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332786"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yueyuan Wang, Maria Bibi, Pengxiang Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-019-0180-y"}], "href": "https://doi.org/10.1186/s11658-019-0180-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31462898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31462898"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yuanwen Zheng, Peihua Nie, Shifeng Xu "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29581"}], "href": "https://doi.org/10.1002/jcb.29581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31916278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31916278"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Libing Feng, Susana Guedes, Tongwen Wang "}, {"type": "b", "children": [{"type": "t", "text": "Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403221200"}], "href": "https://doi.org/10.1074/jbc.M403221200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15051726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15051726"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Satoshi Iwata, Akiko Souta-Kuribara, Akio Yamakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208261"}], "href": "https://doi.org/10.1038/sj.onc.1208261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15592516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15592516"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Yonghong Li, Andrew Grupe, Charles Rowland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm348"}], "href": "https://doi.org/10.1093/hmg/ddm348"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18063669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18063669"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Marie-Line Garron, Diana Arsenieva, Jessie Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.12.010"}], "href": "https://doi.org/10.1016/j.jmb.2008.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19103205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19103205"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Jing Jin Gu, Catherine P Lavau, Elena Pugacheva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2002632"}], "href": "https://doi.org/10.1126/scisignal.2002632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22810897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22810897"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Zhipeng Wang, Min Shen, Peng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13852"}], "href": "https://doi.org/10.18632/oncotarget.13852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27974675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27974675"}]}]}]}