{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNEK6 plays a central role in the faithful execution of mitosis. It is activated during M phase through phosphorylation events—most notably at Ser206—and acts downstream of upstream regulators such as Nek9 and Plk1 to promote proper spindle assembly, centrosome clustering, and the metaphase–anaphase transition. Moreover, NEK6 phosphorylates key substrates including histones H1/H3, microtubule‐associated proteins like EML4, and factors that regulate spindle microtubule dynamics and the DNA damage checkpoint, thereby ensuring timely progression through mitosis and chromosomal stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells, NEK6 overexpression or aberrant activity is frequently associated with tumorigenesis. Its capability to phosphorylate oncogenic transcription factors such as STAT3 and to interact with regulatory proteins like Pin1 contributes to anchorage‐independent transformation and resistance to p53‐mediated senescence. NEK6 has been implicated in a variety of malignancies—including hepatocellular carcinoma, breast cancer, prostate cancer, B cell lymphoma, and colorectal tumors—where it promotes cell cycle progression, suppresses drug‐induced premature senescence, and modulates transforming growth factor–β signaling through interactions with Smad4."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical roles in mitosis and tumorigenesis, NEK6 also participates in diverse cellular processes. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aaw2939"}], "href": "https://doi.org/10.1126/scisignal.aaw2939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409757"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jian Chen, Li Li, Yuanyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.12.228"}], "href": "https://doi.org/10.1016/j.bbrc.2005.12.228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16476580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16476580"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Young Jin Jeon, Kun Yeong Lee, Yong-Yeon Cho, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nek6 overexpression antagonizes p53-induced senescence in human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.9.23.14059"}], "href": "https://doi.org/10.4161/cc.9.23.14059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21099361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21099361"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hye Jin Jee, Hyun-Ju Kim, Ae Jeong Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.04.083"}], "href": "https://doi.org/10.1016/j.bbrc.2011.04.083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21539811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21539811"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaolei Cao, Yunfei Xia, Junling Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-011-9429-0"}], "href": "https://doi.org/10.1007/s12253-011-9429-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21725899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21725899"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hye Jin Jee, Hyun-Ju Kim, Ae Jeong Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2013.02.012"}], "href": "https://doi.org/10.1016/j.canlet.2013.02.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23416273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23416273"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jie Zuo, Haijie Ma, Hao Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An inhibitory role of NEK6 in TGFβ/Smad signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/bmbrep.2015.48.8.225"}], "href": "https://doi.org/10.5483/bmbrep.2015.48.8.225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25523445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25523445"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Laura O'Regan, Josephina Sampson, Mark W Richards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201409151"}], "href": "https://doi.org/10.1083/jcb.201409151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25940345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25940345"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Emre Gerçeker, Seda Orenay Boyacıoglu, Elmas Kasap, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4187"}], "href": "https://doi.org/10.3892/or.2015.4187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26259750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26259750"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Elmas Kasap, Emre Gerceker, Seda Örenay Boyacıoglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4131-6"}], "href": "https://doi.org/10.1007/s13277-015-4131-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26423403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26423403"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Atish D Choudhury, Anna C Schinzel, Maura B Cotter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-0455"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-0455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27899381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27899381"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yue Huang, Olivia I Koues, Jiang-Yang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.02.067"}], "href": "https://doi.org/10.1016/j.celrep.2017.02.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28329684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28329684"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Zhixian He, Xiaojian Ni, Liuwan Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2018.07.030"}], "href": "https://doi.org/10.1016/j.prp.2018.07.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30153958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30153958"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Zhouyan Bian, Haihan Liao, Yan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0096095"}], "href": "https://doi.org/10.1371/journal.pone.0096095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24763737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24763737"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yugo Hirai, Miki Tamura, Junji Otani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12391"}], "href": "https://doi.org/10.1111/gtc.12391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27396482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27396482"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ying Yu, Tianjin Shen, Xiaoling Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.24104"}], "href": "https://doi.org/10.1002/glia.24104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34643969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34643969"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Isadora Carolina Betim Pavan, Fernanda Luisa Basei, Matheus Brandemarte Severino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells12020256"}], "href": "https://doi.org/10.3390/cells12020256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36672191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36672191"}]}]}]}