NFU1 Gene

Name	NFU1 iron-sulfur cluster scaffold
Description	This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNFU1 is a critical mitochondrial factor in the biosynthesis and maturation of iron–sulfur (Fe–S) clusters. It functions as a late‐acting maturation protein that facilitates the conversion of two [2Fe–2S] units into a [4Fe–4S] cluster that is essential for the activity of several lipoic acid–dependent enzymes such as pyruvate dehydrogenase and succinate dehydrogenase. In patients, mutations in NFU1 disrupt this process, leading to impaired lipoylation and consequent deficits in mitochondrial energy metabolism, which are linked to fatal encephalopathy and pulmonary hypertension, as well as defects in respiratory chain complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in cluster maturation, NFU1 serves as an alternative scaffold and carrier for Fe–S clusters within the mitochondrial machinery. Biochemical studies have shown that NFU1 can bind and coordinate [4Fe–4S] clusters—often in a dimeric state—and its structure reveals a C‐terminal domain with molten globule characteristics that is instrumental for persulfide reductase activity. Furthermore, the existence of distinct mitochondrial and nonmitochondrial isoforms underlines a compartmentalized system in eukaryotic cells, while detailed structural investigations elucidate interaction sites with partner proteins such as ISCU2, ISCA1, and related assembly factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogenic mutations in NFU1 can alter its oligomeric state and impair its ability to receive or transfer Fe–S clusters, with downstream consequences in cellular metabolism and neurodevelopment. For example, specific missense mutations like Gly208Cys lead to abnormal dimerization and defective cluster delivery, ultimately manifesting as a spectrum of clinical phenotypes ranging from severe mitochondrial encephalopathy to hereditary spastic paraplegia. Experimental models, including studies in human cells and Caenorhabditis elegans, have linked these mutations to defects not only in mitochondrial enzyme complexes but also in neuromuscular signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, NFU1 is part of a broader family of NifU-like proteins, a relationship highlighted by its structural and functional similarities with proteins such as HIRIP5—which interacts with other factors including laforin—suggesting evolutionary conservation of mechanisms in Fe–S cluster management. Together, these studies establish NFU1 as a pivotal component that not only assembles and transfers Fe–S clusters to specific target proteins but also coordinates with multiple partners to ensure proper mitochondrial function and cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jessie M Cameron, Alexandre Janer, Valeriy Levandovskiy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.08.011"}], "href": "https://doi.org/10.1016/j.ajhg.2011.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21944046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21944046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aleix Navarro-Sastre, Frederic Tort, Oliver Stehling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.10.005"}], "href": "https://doi.org/10.1016/j.ajhg.2011.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22077971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22077971"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xènia Ferrer-Cortès, Aida Font, Núria Bujan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein expression profiles in patients carrying NFU1 mutations. Contribution to the pathophysiology of the disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-012-9565-z"}], "href": "https://doi.org/10.1007/s10545-012-9565-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23179554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23179554"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wing-Hang Tong, Guy N L Jameson, Boi Hanh Huynh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1732541100"}], "href": "https://doi.org/10.1073/pnas.1732541100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12886008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12886008"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yushi Liu, Wenbin Qi, J A Cowan "}, {"type": "b", "children": [{"type": "t", "text": "Iron-sulfur cluster biosynthesis: functional characterization of the N- and C-terminal domains of human NFU."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi801645z"}], "href": "https://doi.org/10.1021/bi801645z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19146390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19146390"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yushi Liu, J A Cowan "}, {"type": "b", "children": [{"type": "t", "text": "Iron-sulfur cluster biosynthesis: characterization of a molten globule domain in human NFU."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi9002524"}], "href": "https://doi.org/10.1021/bi9002524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19722697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19722697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anshika Jain, Anamika Singh, Nunziata Maio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assembly of the [4Fe-4S] cluster of NFU1 requires the coordinated donation of two [2Fe-2S] clusters from the scaffold proteins, ISCU2 and ISCA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa172"}], "href": "https://doi.org/10.1093/hmg/ddaa172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32776106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32776106"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Veronica Nasta, Dafne Suraci, Spyridon Gourdoupis, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Structural Plasticity of NFU1 Upon Interaction with Binding Partners: Insights into the Mitochondrial [4Fe-4S] Cluster Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2023.168154"}], "href": "https://doi.org/10.1016/j.jmb.2023.168154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37211204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37211204"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hong-Hwa Chen, Jen-Kou Lin, Joe-Bin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neoadjuvant therapy of bevacizumab in combination with oxaliplatin and capecitabine (XELOX) for patients with metastatic colorectal cancer with unresectable liver metastases: a phase II, open-label, single-arm, noncomparative trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asia Pac J Clin Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ajco.12692"}], "href": "https://doi.org/10.1111/ajco.12692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28906589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28906589"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nathaniel A Wesley, Christine Wachnowsky, Insiya Fidai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.14271"}], "href": "https://doi.org/10.1111/febs.14271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28906594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28906594"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rauan Kaiyrzhanov, Maha S Zaki, Tracy Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic continuum of NFU1-related disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Transl Neurol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acn3.51679"}], "href": "https://doi.org/10.1002/acn3.51679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36256512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36256512"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peter A Kropp, Philippa Rogers, Sydney E Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patient-specific variants of NFU1/NFU-1 disrupt cholinergic signaling in a model of multiple mitochondrial dysfunctions syndrome 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.049594"}], "href": "https://doi.org/10.1242/dmm.049594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36645076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36645076"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yasemin G Kurt, Bulent Kurt, Ibrahim Aydin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NFU1 gene mutation and mitochondrial disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurol India (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/0028-3886.185402"}], "href": "https://doi.org/10.4103/0028-3886.185402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27381105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27381105"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hui Zhong, Alexandre Janer, Oleh Khalimonchuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkad842"}], "href": "https://doi.org/10.1093/nar/gkad842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37823603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37823603"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Subramaniam Ganesh, Naomi Tsurutani, Toshimitsu Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg253"}], "href": "https://doi.org/10.1093/hmg/ddg253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12915448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12915448"}]}]}]}
Synonyms	MMDS1, HIRIP, NFU, NIFUC, HIRIP5, CGI-33
Proteins	NFU1_HUMAN
NCBI Gene ID	27247
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NFU1 has 5,456 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for NFU1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NFU1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFU1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFU1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NFU1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NFU1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NFU1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFU1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NFU1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFU1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFU1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFU1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NFU1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NFU1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFU1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NFU1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NFU1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with NFU1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NFU1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NFU1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NFU1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NFU1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NFU1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NFU1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NFU1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFU1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NFU1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NFU1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NFU1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NFU1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NFU1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate NFU1 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving NFU1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NFU1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NFU1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NFU1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NFU1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NFU1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NFU1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFU1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NFU1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NFU1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.