NGFR Gene

HGNC Family	CD molecules (CD), Tumor necrosis factor receptor superfamily (TNFRSF)
Name	nerve growth factor receptor
Description	Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNGFR—also known as the p75 neurotrophin receptor—plays a multifaceted role in the nervous system by modulating neurite outgrowth, mediating inhibitory signals from myelin‐associated molecules, and orchestrating life–death decisions during development and after injury. In neurons, ligand‐induced interactions of NGFR with co‐receptors (for example, forming complexes with p75 and TrkA) trigger regulated proteolytic cleavages that generate intracellular domains capable of nuclear translocation and gene modulation. These events underlie processes ranging from the suppression or promotion of apoptosis (for instance, in the context of beta‐amyloid toxicity and retinal injury) to the fine‐tuning of signaling pathways that direct neurite extension and neural survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "NGFR has also emerged as a critical player in tumor biology. In various malignancies—including melanoma, neuroblastoma, and glioma—NGFR (often identified by its alternative designation, CD271) marks cancer stem cell compartments and drives processes such as phenotype switching, increased invasiveness, and resistance to apoptosis or immunotherapeutic interventions. Aberrant NGFR signaling may also impinge on key tumor suppressor pathways (for example, through p53 inactivation), thereby contributing to tumor progression, metastatic dissemination, and even therapeutic resistance in cancers ranging from cutaneous melanomas to esophageal carcinomas."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "23"}]}, {"type": "t", "text": "In addition, NGFR serves as an important stem cell marker in non‐neoplastic tissues, where its expression defines subpopulations endowed with high clonogenicity and self‐renewal potential. Whether in esophageal or oral epithelia or in pluripotent stem cell–derived progenitors, NGFR helps maintain stem cell niches and regulates the balance between proliferation, differentiation, and survival—functions that are critical for effective tissue repair and homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "28"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Giovanni Perini, Vittorina Della-Bianca, Valeria Politi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20011797"}], "href": "https://doi.org/10.1084/jem.20011797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11927634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11927634"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kevin C Wang, Jieun A Kim, Rajeev Sivasankaran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01176"}], "href": "https://doi.org/10.1038/nature01176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12422217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12422217"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kwang-Mook Jung, Serena Tan, Natalie Landman, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The biological role of the low-affinity p75 neurotrophin receptor in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-05-2852"}], "href": "https://doi.org/10.1158/1078-0432.CCR-05-2852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16951226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16951226"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Takahiro Nakamura, Ken-ichi Endo, Shigeru Kinoshita "}, {"type": "b", "children": [{"type": "t", "text": "Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.2006-0494"}], "href": "https://doi.org/10.1634/stemcells.2006-0494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17110619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17110619"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yoshikazu Mikami, Yumiko Ishii, Nobukazu Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD271/p75(NTR) inhibits the differentiation of mesenchymal stem cells into osteogenic, adipogenic, chondrogenic, and myogenic lineages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2010.0299"}], "href": "https://doi.org/10.1089/scd.2010.0299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21142793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21142793"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Michael R Hicks, Julia Hiserodt, Katrina Paras, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-017-0010-2"}], "href": "https://doi.org/10.1038/s41556-017-0010-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29255171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29255171"}]}]}]}
Synonyms	P75NTR, CD271, TNFRSF16, P75(NTR), GP80-LNGFR
Proteins	TNR16_HUMAN
NCBI Gene ID	4804
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NGFR has 10,488 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 136 datasets.

Click the + buttons to view associations for NGFR from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NGFR Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NGFR gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NGFR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NGFR gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NGFR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NGFR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NGFR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving NGFR protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NGFR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NGFR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NGFR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NGFR gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NGFR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NGFR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with NGFR gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NGFR protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NGFR gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NGFR gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NGFR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NGFR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NGFR gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NGFR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NGFR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NGFR protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NGFR protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NGFR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NGFR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NGFR protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NGFR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NGFR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NGFR gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NGFR gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NGFR gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NGFR protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NGFR gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NGFR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NGFR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NGFR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NGFR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NGFR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NGFR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.