{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNLRX1 is a unique, mitochondria‐localized member of the NOD‐like receptor family that plays a central role in fine‐tuning innate antiviral defenses. Early studies demonstrated that NLRX1 localizes to the mitochondrial outer membrane or matrix where it interacts with key adaptor proteins such as MAVS, thereby inhibiting RIG‐I–mediated type I interferon responses while simultaneously modulating the production of reactive oxygen species (ROS). In addition, NLRX1 has been shown to engage with partner molecules like TUFM to both attenuate excessive cytokine production and promote autophagy, and even orchestrate differential regulation of transcription factors (eg, suppressing IRF3 activation while facilitating IRF1 expression) to balance effective antiviral immunity with tissue protection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its antiviral functions, NLRX1 exerts broad control over cellular responses to infection and tissue injury. In bacterial challenges such as Chlamydia trachomatis infection, NLRX1 enhances ROS production that is exploited by the pathogen to drive caspase‐1 activation, while in the airway epithelium it mediates dsRNA‐induced mitochondrial ROS generation leading to barrier disruption. Furthermore, NLRX1 has been implicated in modulating MAVS turnover during viral infections like hepatitis C, thereby tuning interferon responses, and it plays a protective role during brain and myocardial injury by dampening inflammation and apoptosis. Additional studies in models of smoke‐induced pulmonary injury, EGFR‐targeted therapy resistance in head and neck cancer, and even histiocytic sarcoma further underscore its dual role in controlling inflammasome activation, autophagy, and cell survival in response to diverse stressors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent findings extend the impact of NLRX1 into the realms of immuno‐metabolic regulation, tumor suppression, and autoimmunity. Altered NLRX1 expression and rare genetic variants have been associated with viral persistence in hepatitis B and reduced expression in colorectal and breast cancers, where it influences mitochondrial respiration, ATP production, and autophagic flux. Moreover, studies in sepsis models, multiple sclerosis, and even in the context of innate immune signaling in fungal and viral infections highlight its role as an immuno‐metabolic hub—one that integrates mitochondrial RNA processing, modulates inflammasome and NF‐κB pathways, and ultimately regulates cell death, inflammation, and tissue homeostasis. Collectively, these insights position NLRX1 as a promising biomarker and therapeutic target, whose multifaceted actions underscore its critical role in balancing host defense with inflammatory damage across a spectrum of diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_fs", "start_ref": "20", "end_ref": "31"}, {"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chris B Moore, Daniel T Bergstralh, Joseph A Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 is a regulator of mitochondrial antiviral immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06501"}], "href": "https://doi.org/10.1038/nature06501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18200010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18200010"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ivan Tattoli, Leticia A Carneiro, Muguette Jéhanno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7401161"}], "href": "https://doi.org/10.1038/sj.embor.7401161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18219313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18219313"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Damien Arnoult, Fraser Soares, Ivan Tattoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.051193"}], "href": "https://doi.org/10.1242/jcs.051193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19692591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19692591"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu Lei, Haitao Wen, Yanbao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.03.025"}], "href": "https://doi.org/10.1016/j.immuni.2012.03.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22749352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22749352"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu Lei, Haitao Wen, Jenny P Y Ting "}, {"type": "b", "children": [{"type": "t", "text": "The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.23026"}], "href": "https://doi.org/10.4161/auto.23026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23321557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23321557"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hui Feng, Erik M Lenarcic, Daisuke Yamane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3853"}], "href": "https://doi.org/10.1038/ni.3853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28967880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28967880"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhe Ma, Sharon E Hopcraft, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1006350"}], "href": "https://doi.org/10.1371/journal.ppat.1006350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28459883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28459883"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ali A Abdul-Sater, Najwane Saïd-Sadier, Verissa M Lam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.137885"}], "href": "https://doi.org/10.1074/jbc.M110.137885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20959452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20959452"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Benjamin L Unger, Shyamala Ganesan, Adam T Comstock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.03039-13"}], "href": "https://doi.org/10.1128/JVI.03039-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24429360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24429360"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yuwen Qin, Binbin Xue, Chunyan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01264-17"}], "href": "https://doi.org/10.1128/JVI.01264-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28956771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28956771"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Arthur Ling, Fraser Soares, David O Croitoru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.333146"}], "href": "https://doi.org/10.1074/jbc.M111.333146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22718770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22718770"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Min-Jong Kang, Chang Min Yoon, Bo Hye Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of NLRX1 in chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI71747"}], "href": "https://doi.org/10.1172/JCI71747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25938787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25938787"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hongyan Li, Shanshan Zhang, Faliang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2016.06.013"}], "href": "https://doi.org/10.1016/j.molimm.2016.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27393910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27393910"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kritarth Singh, Anastasia Poteryakhina, Andrei Zheltukhin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2015.01.016"}], "href": "https://doi.org/10.1016/j.bbamcr.2015.01.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25639646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25639646"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Y Lei, B A Kansy, J Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.11"}], "href": "https://doi.org/10.1038/onc.2016.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26876213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26876213"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sheryl Coutermarsh-Ott, Alysha Simmons, Vittoria Capria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8861"}], "href": "https://doi.org/10.18632/oncotarget.8861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27105514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27105514"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Bin He, Wei Chen, Jingsong Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202618"}], "href": "https://doi.org/10.18632/aging.202618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33686956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33686956"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kritarth Singh, Milton Roy, Paresh Prajapati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2019.02.018"}], "href": "https://doi.org/10.1016/j.bbadis.2019.02.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30802640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30802640"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kritarth Singh, Lakshmi Sripada, Anastasia Lipatova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2018.06.008"}], "href": "https://doi.org/10.1016/j.bbamcr.2018.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29932989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29932989"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Qiang Zhao, Liang Peng, Weijun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare inborn errors associated with chronic hepatitis B virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.25850"}], "href": "https://doi.org/10.1002/hep.25850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22610944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22610944"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.3000451"}], "href": "https://doi.org/10.1371/journal.pbio.3000451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31525189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31525189"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Tünde Fekete, Dóra Bencze, Eduárd Bíró, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Focusing on the Cell Type Specific Regulatory Actions of NLRX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22031316"}], "href": "https://doi.org/10.3390/ijms22031316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33525671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33525671"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Luke A J O'Neill "}, {"type": "b", "children": [{"type": "t", "text": "Innate immunity: squelching anti-viral signalling with NLRX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2008.02.021"}], "href": "https://doi.org/10.1016/j.cub.2008.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18397740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18397740"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Tiia Snäkä, Nicolas Fasel "}, {"type": "b", "children": [{"type": "t", "text": "Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2020.609812"}], "href": "https://doi.org/10.3389/fcimb.2020.609812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33344269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33344269"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yu Liu, Ningning Tang, Ke Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Low Extrem Wounds (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1534734618794856"}], "href": "https://doi.org/10.1177/1534734618794856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30141361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30141361"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yaxin Ding, Wenjie Sun, Mingwei Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-024-02364-y"}], "href": "https://doi.org/10.1007/s12032-024-02364-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38683455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38683455"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Paul Y Bi, Samuel A Killackey, Linus Schweizer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bj.2023.100635"}], "href": "https://doi.org/10.1016/j.bj.2023.100635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37574163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37574163"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Qian Wang, Fengying He, Liping Wu "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 increases human retinal pigment epithelial autophagy and reduces H"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergol Immunopathol (Madr) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15586/aei.v51i1.766"}], "href": "https://doi.org/10.15586/aei.v51i1.766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36617838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36617838"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Bridget Kastelberg, Tariq Ayubi, Nuria Tubau-Juni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nlrx1-Regulated Defense and Metabolic Responses to "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Aspergillus fumigatus"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Are Morphotype and Cell Type Specific."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.749504"}], "href": "https://doi.org/10.3389/fimmu.2021.749504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34790195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34790195"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Eric M Pietras, Genhong Cheng "}, {"type": "b", "children": [{"type": "t", "text": "New tricks for old NODs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2008-9-4-217"}], "href": "https://doi.org/10.1186/gb-2008-9-4-217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18466630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18466630"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Jie Tao, Jinghua Cheng, Ying Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells13110913"}], "href": "https://doi.org/10.3390/cells13110913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38891045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38891045"}]}]}]}