NOL7 Gene

Name	nucleolar protein 7, 27kDa
Description	The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNOL7 is emerging as a multifunctional tumor suppressor whose expression is tightly regulated at the transcriptional level. Detailed promoter analyses have identified two transcriptional start sites within a TATA‐less, GC-rich region that is bound by key regulatory factors—such as SP1, c‐Myc, and RXRα—to maintain its normal expression. In cervical cancer, however, NOL7 is often inactivated via loss of heterozygosity and somatic mutations, with its reduced expression correlating with disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to controlling gene expression, NOL7 exerts post‐transcriptional regulatory functions that contribute to its antiangiogenic and tumor‐suppressive activities. It achieves this, in part, by binding to the 3′ untranslated region of thrombospondin-1 (TSP-1) mRNA within the nucleoplasm, which leads to increased mRNA stability and enhanced expression of TSP-1, a potent endogenous inhibitor of angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMultiple alternatively spliced isoforms of NOL7 underscore its diverse cellular roles. The longest isoform (NOL7-SP1) localizes predominantly to the nucleolus, where it is essential for maintaining proper nucleolar architecture and normal rates of cell growth. Moreover, NOL7 appears to be the human ortholog of yeast Bud21, playing a critical role in early pre–rRNA accumulation and pre–18S rRNA processing, thereby linking it to the fundamental process of ribosome biogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent findings have also implicated a nucleolar form of NOL7, known as PQBP3, in the regulation of cellular senescence and neurodegeneration. In neurons, PQBP3 interacts with proteasome activator complexes to protect Lamin B1 from degradation, thereby preserving nuclear membrane integrity and preventing cytoplasmic DNA leakage—a mechanism that may mitigate senescence-like phenotypes linked to neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tanmayi P Mankame, Guolin Zhou, Mark W Lingen "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the human NOL7 gene promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2010.02.008"}], "href": "https://doi.org/10.1016/j.gene.2010.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20206243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20206243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Colleen L Doçi, Tanmayi P Mankame, Alexander Langerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PGP.0b013e318220ba16"}], "href": "https://doi.org/10.1097/PGP.0b013e318220ba16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22123719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22123719"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C L Doçi, G Zhou, M W Lingen "}, {"type": "b", "children": [{"type": "t", "text": "The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.464"}], "href": "https://doi.org/10.1038/onc.2012.464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23085760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23085760"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Noa Kinor, Yaron Shav-Tal "}, {"type": "b", "children": [{"type": "t", "text": "The dynamics of the alternatively spliced NOL7 gene products and role in nucleolar architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleus (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/nucl.2.3.15893"}], "href": "https://doi.org/10.4161/nucl.2.3.15893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21818416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21818416"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mason A McCool, Carson J Bryant, Hannah Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2023.2217392"}], "href": "https://doi.org/10.1080/15476286.2023.2217392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37246770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37246770"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuki Yoshioka, Yong Huang, Xiaocen Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s44318-024-00192-4"}], "href": "https://doi.org/10.1038/s44318-024-00192-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39103492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39103492"}]}]}]}
Synonyms	C6ORF90, RARG-1, DJ223E5.2, PQBP3
Proteins	NOL7_HUMAN
NCBI Gene ID	51406
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NOL7 has 5,544 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 103 datasets.

Click the + buttons to view associations for NOL7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NOL7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOL7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOL7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NOL7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NOL7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NOL7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOL7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NOL7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOL7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOL7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NOL7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOL7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NOL7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NOL7 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOL7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NOL7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NOL7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of NOL7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NOL7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NOL7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NOL7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NOL7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NOL7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NOL7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NOL7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOL7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NOL7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with NOL7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NOL7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NOL7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NOL7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NOL7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NOL7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NOL7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOL7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NOL7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NOL7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NOL7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NOL7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NOL7 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of NOL7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.