NOLC1 Gene

Name	nucleolar and coiled-body phosphoprotein 1
Description	Enables molecular function inhibitor activity; protein heterodimerization activity; and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Acts upstream of or within axonogenesis and regulation of synaptic plasticity. Located in fibrillar center. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNucleolar and coiled‐body phosphoprotein 1 (NOLC1), also known as Nopp140, is a highly dynamic, multifunctional protein that plays a central role in nucleolar organization and ribosome biogenesis. Its intrinsically disordered nature allows NOLC1 to serve as a flexible scaffold that coordinates the assembly, fusion, and maintenance of nucleoli and Cajal bodies. In these compartments, NOLC1 associates with small nucleolar ribonucleoproteins (snoRNPs) and small Cajal body–specific RNPs (scaRNPs) to facilitate rRNA processing and ribosomal synthesis. Transcription of the NOLC1 gene is positively regulated by factors such as NF‐κB and CREB, and its dynamic subcellular distribution—demonstrated by its reversible association with nucleolar and Cajal body structures during the cell cycle—is crucial for efficient pre‐rRNA processing and ribosome production."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its fundamental role in ribosome biogenesis, NOLC1 is critically involved in the regulation of cell proliferation and oncogenesis. Aberrant expression or epigenetic silencing of NOLC1 has been observed in several tumor types. For example, enhanced expression of NOLC1 in nasopharyngeal carcinoma appears to promote tumor growth via a synergistic activation of the MDM2 promoter in cooperation with p53, whereas hypermethylation and consequent downregulation of NOLC1 in hepatocellular carcinoma are associated with altered proliferation and apoptosis. Overexpression of NOLC1 also correlates with multidrug resistance in non‐small cell lung cancer, and even oncogenic gene fusions involving NOLC1 (such as the Pten–NOLC1 fusion) have been shown to drive aberrant activation of growth factor receptors and their downstream signaling pathways. Elevated levels in prostate and colorectal cancers further underscore its importance as a modulator of cancer cell proliferation and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNOLC1 also functions as a regulatory hub via numerous protein–protein interactions that influence key signaling pathways. It binds to and negatively regulates the catalytic activity of protein kinase CK2 through a direct association with its α subunit, with its disordered C-terminal region undergoing conformational rearrangements upon binding. Moreover, NOLC1 is a target of viral proteins; for instance, the effector domain of influenza A virus nonstructural protein 1 (NS1) interacts with NOLC1—a binding that has been mapped to specific NS1 residues—to potentially modulate nucleolar functions under viral infection. In line with these roles, NOLC1 mediates the nucleolar shuttling of telomeric repeat‐binding factor 2 (TRF2), thereby promoting rDNA transcription and influencing the cell’s response to nucleolar stress. In addition, interactions with cell surface glycolipids such as ganglioside GM3 have been observed in breast cancer models, suggesting further complexity in its regulatory repertoire."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chi-Ming Chiu, Yeou-Guang Tsay, Ching-Jin Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205915200"}], "href": "https://doi.org/10.1074/jbc.M205915200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12167624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12167624"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chen Wang, Charles C Query, U Thomas Meier "}, {"type": "b", "children": [{"type": "t", "text": "Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.24.8457-8466.2002"}], "href": "https://doi.org/10.1128/MCB.22.24.8457-8466.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12446766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12446766"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi-Tzang Tsai, Chen-I Lin, Hung-Kai Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin tethering effects of hNopp140 are involved in the spatial organization of nucleolus and the rRNA gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11373-007-9226-7"}], "href": "https://doi.org/10.1007/s11373-007-9226-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18253863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18253863"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Benoît Renvoisé, Sabrina Colasse, Philippe Burlet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp009"}], "href": "https://doi.org/10.1093/hmg/ddp009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19129172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19129172"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marc Thiry, Thierry Cheutin, Françoise Lamaye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localization of Nopp140 within mammalian cells during interphase and mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-009-0599-8"}], "href": "https://doi.org/10.1007/s00418-009-0599-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19381672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19381672"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xuesong Gao, Qi Wang, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/BMBRep.2011.44.1.70"}], "href": "https://doi.org/10.5483/BMBRep.2011.44.1.70"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21266110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21266110"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Agnes Tantos, Kriszta Szrnka, Beata Szabo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Roles of NOLC1 in cancers and viral infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-04934-5"}], "href": "https://doi.org/10.1007/s00432-023-04934-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37296317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37296317"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yu-Chyi Hwang, Tung-Ying Lu, Dah-Yeou Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080931"}], "href": "https://doi.org/10.2353/ajpath.2009.080931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19541936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19541936"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xuefei Duan, Jinqian Zhang, Shunai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2676"}], "href": "https://doi.org/10.3892/or.2013.2676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23970161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23970161"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Huaping Huang, Tangying Li, Mingjing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-018-0119-8"}], "href": "https://doi.org/10.1186/s11658-018-0119-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30505321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30505321"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jian-Hua Luo, Silvia Liu, Junyan Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01582-8"}], "href": "https://doi.org/10.1038/s41388-020-01582-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33323972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33323972"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wansoo Kim, Dong-Yeop Yeo, Seong-Kyoon Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.10.038"}], "href": "https://doi.org/10.1016/j.bbrc.2022.10.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36265288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36265288"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zhiwei Sun, Qianshi Zhang, Jinjuan Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-05297-7"}], "href": "https://doi.org/10.1007/s00432-023-05297-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37670166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37670166"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yun-Kyoung Kim, Kong Joo Lee, Hyesung Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604785200"}], "href": "https://doi.org/10.1074/jbc.M604785200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17038328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17038328"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Won-Kyu Lee, Sang-Yeop Lee, Woo-Il Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Genes (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11262-012-0849-z"}], "href": "https://doi.org/10.1007/s11262-012-0849-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23188192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23188192"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chun-Yu Zhu, Fang-Liang Zheng, Xiao-Shuang She, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Genes (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11262-015-1166-0"}], "href": "https://doi.org/10.1007/s11262-015-1166-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25645906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25645906"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jung-Hyun Na, Won-Kyu Lee, Yuyoung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.06.040"}], "href": "https://doi.org/10.1016/j.bbrc.2016.06.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27297113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27297113"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Fuwen Yuan, Chenzhong Xu, Guodong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0572-3"}], "href": "https://doi.org/10.1038/s41419-018-0572-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29725012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29725012"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hyunju Choi, Hee-Do Kim, Yeon-Woo Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2023.109810"}], "href": "https://doi.org/10.1016/j.abb.2023.109810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37939867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37939867"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Man Zhang, Yingyue Zeng, Fengchao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of the Nonstructural Protein-Nucleolar and Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "AIDS Res Hum Retroviruses (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/AID.2023.0067"}], "href": "https://doi.org/10.1089/AID.2023.0067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38062753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38062753"}]}]}]}
Synonyms	NOPP130, NS5ATP13, NOPP140
Proteins	NOLC1_HUMAN
NCBI Gene ID	9221
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NOLC1 has 11,863 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for NOLC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NOLC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOLC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NOLC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NOLC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NOLC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOLC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving NOLC1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NOLC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOLC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOLC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NOLC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOLC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NOLC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NOLC1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOLC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NOLC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NOLC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NOLC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NOLC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NOLC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NOLC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NOLC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NOLC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NOLC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NOLC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NOLC1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NOLC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NOLC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NOLC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NOLC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NOLC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NOLC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NOLC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NOLC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NOLC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NOLC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOLC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NOLC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NOLC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NOLC1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NOLC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.