{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNOS1AP, also known as CAPON, is a multifunctional adaptor protein that plays a central role in cardiac electrophysiology. A large body of genetic and functional evidence demonstrates that common sequence variants in NOS1AP modulate myocardial repolarization by regulating neuronal nitric oxide synthase (nNOS) activity. These variants have been repeatedly associated with alterations in the QT interval, thereby influencing susceptibility to both congenital and acquired long QT syndromes, arrhythmias, and sudden cardiac death. Moreover, experimental studies show that NOS1AP interacts with nNOS to affect L‐type calcium channel activity, and its localization within cardiomyocytes—such as at the sarcoplasmic reticulum, intercalated discs, and caveolae—appears to be critical for these electrophysiological effects, as well as for the remodeling processes after myocardial injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its cardiac functions, NOS1AP is a key modulator within the central nervous system. By binding to nNOS and other synaptic proteins, such as synapsins, NOS1AP influences NMDA receptor–mediated signaling and is a determinant of dendritic development. Differential expression of its isoforms has been shown to regulate dendrite outgrowth, branching, and spine morphology. Genetic association studies have implicated NOS1AP in neuropsychiatric disorders including schizophrenia, posttraumatic stress disorder, and depression, suggesting that changes in NOS1AP expression or protein–protein interactions may underlie synaptic dysregulation and altered cognitive function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further indicates that NOS1AP participates in diverse cellular processes beyond cardiac and synaptic signaling. In metastatic breast cancer cells, NOS1AP forms part of a complex with polarity proteins such as SCRIB and VANGL1, thereby influencing cell migration and the establishment of front–rear polarity. 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