NOTCH4 Gene

HGNC Family	Ankyrin repeat domain containing (ANKRD)
Name	notch 4
Description	This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNotch4 has emerged as a critical mediator in cancer biology, especially in breast cancer where its signaling is preferentially elevated in stem cell–enriched populations. In breast tumors, Notch4 activity is markedly higher than that of other Notch receptors, and its inhibition completely prevents tumor initiation. Furthermore, increased Notch4 signaling—driven in part by factors such as the ETS transcription factor PEA3—correlates with anti‐estrogen resistance and aggressive behavior in both estrogen receptor–positive and triple‐negative breast cancers, underscoring its potential as a promising therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the vascular context, Notch4 is predominantly expressed on endothelial cells where its activated form serves to modulate angiogenesis and vascular integrity. Constitutive activation of Notch4 in endothelial cells inhibits angiogenic sprouting and disrupts vascular endothelial growth factor–induced neovascularization by enhancing beta1‐integrin–mediated adhesion. In parallel, Notch4 activity also contributes to endothelial cell survival by limiting proapoptotic signaling cascades, while in vascular smooth muscle cells it reinforces differentiation through upregulation of smooth muscle–specific markers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its functions in breast and vascular biology, Notch4 also plays pivotal roles in other malignancies. In metastatic melanoma cells, Notch4 acts upstream of Nodal to induce an aggressive tumor phenotype characterized by enhanced invasion, anchorage-independent growth, and vasculogenic mimicry. Moreover, the intracellular domain of Notch4 can bind Smad3 to attenuate TGF‐β–mediated growth inhibition in breast cancer, while in head and neck squamous cell carcinoma a Notch4–HEY1 pathway promotes proliferation, cisplatin resistance, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotch4 expression is also subject to nuanced regulation in diverse physiologic and pathologic contexts. In podocytes, for example, the histone deacetylase Sirt6 dampens Notch4 transcription—along with Notch1—to protect against proteinuric kidney injury. In hematologic malignancies such as B‐acute lymphoblastic leukemia, neutralization of Notch4 (in combination with Notch3 and ligand blockade) disrupts stromal support and promotes leukemic cell apoptosis. Additionally, increased Notch4 expression on circulating regulatory T cells has been associated with severe lung inflammation in COVID-19, where it restricts the induction of amphiregulin necessary for tissue repair. Genetic association studies further implicate the NOTCH4 locus in age-related macular degeneration, suggesting broader roles in human disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hannah Harrison, Gillian Farnie, Sacha J Howell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-1681"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-1681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20068161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20068161"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paola Rizzo, Haixi Miao, Gwendolyn D'Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-5744"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-5744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18593923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18593923"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jodi Speiser, Kimberly Foreman, Eva Drinka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Surg Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1066896911427035"}], "href": "https://doi.org/10.1177/1066896911427035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22084425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22084425"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anthony G Clementz, Allison Rogowski, Kinnari Pandya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr2900"}], "href": "https://doi.org/10.1186/bcr2900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21679465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21679465"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhibo Liu, Xinxin Chen, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.584821"}], "href": "https://doi.org/10.1074/jbc.M114.584821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25164809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25164809"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kevin G Leong, Xiaolong Hu, Linheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.8.2830-2841.2002"}], "href": "https://doi.org/10.1128/MCB.22.8.2830-2841.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11909975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11909975"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Farrell MacKenzie, Patrick Duriez, Fred Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312102200"}], "href": "https://doi.org/10.1074/jbc.M312102200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14701863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14701863"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Carrie J Shawber, Indranil Das, Esther Francisco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch signaling in primary endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1749-6632.2003.tb03219.x"}], "href": "https://doi.org/10.1111/j.1749-6632.2003.tb03219.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12814948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12814948"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yuefeng Tang, Sumithra Urs, Lucy Liaw "}, {"type": "b", "children": [{"type": "t", "text": "Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.165134"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.165134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18239137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18239137"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Katharine M Hardy, Dawn A Kirschmann, Elisabeth A Seftor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-0705"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-0705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21159651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21159651"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Youping Sun, William Lowther, Katsuaki Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208528"}], "href": "https://doi.org/10.1038/sj.onc.1208528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16007227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16007227"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Takahito Fukusumi, Theresa W Guo, Akihiro Sakai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00498-4"}], "href": "https://doi.org/10.1038/s41467-017-00498-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28871079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28871079"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Armel Hervé Nwabo Kamdje, Federico Mosna, Francesco Bifari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-12-326694"}], "href": "https://doi.org/10.1182/blood-2010-12-326694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21602525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21602525"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Valentina Cipriani, Hin-Tak Leung, Vincent Plagnol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds225"}], "href": "https://doi.org/10.1093/hmg/dds225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22694956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22694956"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hani Harb, Mehdi Benamar, Peggy S Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2021.04.002"}], "href": "https://doi.org/10.1016/j.immuni.2021.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33915108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33915108"}]}]}]}
Synonyms	INT3
Proteins	NOTC4_HUMAN
NCBI Gene ID	4855
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NOTCH4 has 7,249 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for NOTCH4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NOTCH4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOTCH4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOTCH4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NOTCH4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NOTCH4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NOTCH4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOTCH4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NOTCH4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOTCH4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOTCH4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NOTCH4 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOTCH4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NOTCH4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with NOTCH4 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NOTCH4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOTCH4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NOTCH4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NOTCH4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NOTCH4 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NOTCH4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NOTCH4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NOTCH4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NOTCH4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NOTCH4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOTCH4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NOTCH4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NOTCH4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NOTCH4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NOTCH4 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NOTCH4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving NOTCH4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NOTCH4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NOTCH4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NOTCH4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NOTCH4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NOTCH4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NOTCH4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NOTCH4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOTCH4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NOTCH4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NOTCH4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.