{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNote that none of the provided abstracts mention “NPEPL1.” Instead, the collective literature focuses on the multifaceted roles of the neuropeptide Y (NPY) system – and particularly its Y2 receptor subtype – in central and peripheral regulation. These studies demonstrate that NPY‐Y2 receptor signaling, which predominantly acts in a presynaptic inhibitory manner to modulate neurotransmitter release, is integral to the control of food intake, energy and glucose homeostasis, and endocrine as well as autonomic functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA series of reports further reveal that alterations in Y2 receptor signaling affect metabolic and skeletal regulation. In various knockout and conditional deletion models, reduced Y2 activity has been associated with significant changes in feeding behavior, adiposity, and compensatory increases in osteoblast activity that lead to higher bone mass and enhanced angiogenesis. These effects underscore a dual role for Y2 (and interacting Y receptor subtypes) in both central control of energy balance and peripheral control of tissue remodelling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations extend this picture by showing that Y2 receptor–mediated neuromodulation influences emotional behaviors, cognitive processing, and nociception. For example, deletion or pharmacological modulation of Y2 receptors alters anxiety‐ and depression-like behavior, impairs aspects of learning and memory, and modulates pain responses. Moreover, Y2 signaling is implicated in the regulation of gastrointestinal motility and secretion as well as in circadian and autonomic processes. Collectively, these findings point to a broad therapeutic potential for targeting Y2 (often in synergy with other Y receptor subtypes) in disorders ranging from obesity and osteoporosis to mood and functional gastrointestinal disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Margaret A Smith-White, Herbert Herzog, Erica K Potter "}, {"type": "b", "children": [{"type": "t", "text": "Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Regul Pept (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-0115(01)00368-8"}], "href": "https://doi.org/10.1016/s0167-0115(01"}, {"type": "t", "text": "00368-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11786149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11786149"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paul A Baldock, Amanda Sainsbury, Michelle Couzens, et al. 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